公开(公告)号：US20240272162A1

公开(公告)日：2024-08-15

申请号：US18435187

申请日：2024-02-07

申请人： DROPLET BIOSCIENCES, INC.

发明人： Marra S. Francis ,  Jose Zevallos ,  Aadel Chaudhuri ,  Theresa Tribble

IPC分类号： G01N33/574 ,  C12Q1/6886

CPC分类号： G01N33/57488 ,  C12Q1/6886 ,  C12Q2600/156 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/5428 ,  G01N2333/545 ,  G01N2333/96494

摘要： The present invention provides methods for using effluent obtained from medical procedures resulting in stomas or percutaneous drains or ports to assess diagnostic biomarkers indicative of disease. Identified biomarkers are used to inform surgical success and/or to assess and monitor efficacy of treatment.

公开(公告)号：US20240241138A1

公开(公告)日：2024-07-18

申请号：US18559096

申请日：2022-05-06

申请人： UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH

发明人： O'Bryant Sid E.

IPC分类号： G01N33/68 ,  G01N21/76 ,  G16H50/20

CPC分类号： G01N33/6896 ,  G01N21/76 ,  G16H50/20 ,  G01N2333/4713 ,  G01N2333/4737 ,  G01N2333/524 ,  G01N2333/525 ,  G01N2333/5409 ,  G01N2333/5412 ,  G01N2333/5418 ,  G01N2333/5428 ,  G01N2333/70525 ,  G01N2333/7151 ,  G01N2333/745 ,  G01N2800/2835

摘要： In one aspect, the present disclosure relates to a method for excluding a subject from the need for diagnostic testing for Parkinson's disease (PD). In another aspect, the present disclosure relates to a method for excluding a subject from recruitment into a clinical study for an investigational PD medication. In yet another aspect, the present disclosure relates to a method for screening a subject to determine whether the subject is ruled out as having PD, wherein the subjects who cannot be ruled out are administered a diagnostic test for PD, a treatment for PD, or a combination thereof.

公开(公告)号：US12025621B2

公开(公告)日：2024-07-02

申请号：US17161783

申请日：2021-01-29

申请人： Alexion Pharmaceuticals, Inc.

发明人： Susan Faas McKnight ,  Roxanne Cofiell ,  Anjli Kukreja ,  Krystin A. Bedard ,  Yan Yan

IPC分类号： G01N31/00 ,  C07K16/18 ,  G01N33/53 ,  G01N33/68 ,  A61K39/00

CPC分类号： G01N33/6893 ,  C07K16/18 ,  G01N33/6863 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/76 ,  G01N2333/4716 ,  G01N2333/485 ,  G01N2333/522 ,  G01N2333/5412 ,  G01N2333/5421 ,  G01N2333/5434 ,  G01N2333/545 ,  G01N2333/57 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2333/70539 ,  G01N2333/7151 ,  G01N2333/7452 ,  G01N2333/75 ,  G01N2333/775 ,  G01N2333/8139 ,  G01N2333/8146 ,  G01N2333/974 ,  G01N2800/226 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52

摘要： The disclosure provides biomarker proteins, a change in the concentration or activity level of which are associated with atypical hemolytic uremic syndrome (aHUS) or clinically meaningful treatment of aHUS with a complement inhibitor. Also provided are compositions and methods for interrogating the concentration and/or activity of one or more of the biomarker proteins in a biological fluid. The compositions and methods are useful for, among other things, evaluating risk for developing aHUS, diagnosing aHUS, determining whether a subject is experiencing the first acute presentation of aHUS, monitoring progression or abatement of aHUS, and/or monitoring response to treatment with a complement inhibitor or optimizing such treatment.

公开(公告)号：US11932850B2

公开(公告)日：2024-03-19

申请号：US17042708

申请日：2019-03-28

申请人： Jill M. Siegfried

发明人： Jill M. Siegfried ,  Christian Nzinkeu Njatcha ,  Mariya Farooqui

IPC分类号： C07H21/02 ,  A61K31/517 ,  A61P35/00 ,  C07H21/04 ,  C12N15/113 ,  G01N33/574

CPC分类号： C12N15/113 ,  A61K31/517 ,  A61P35/00 ,  G01N33/57484 ,  C12N2310/11 ,  C12N2310/13 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/3183 ,  C12N2310/3231 ,  C12N2310/531 ,  C12N2310/532 ,  G01N2333/5412 ,  G01N2333/90245

摘要： Described herein are compositions that inhibit/degrade STAT3, and methods of using such compositions for chemoprevention of non-small cell lung cancer (NSCLC).

公开(公告)号：US11723569B2

公开(公告)日：2023-08-15

申请号：US15818903

申请日：2017-11-21

申请人： JANSSEN PHARMACEUTICA NV

发明人： Dai Wang ,  Srihari Gopal ,  Vaibhav Narayan ,  Adam Savitz ,  Susan Baker

IPC分类号： A61B5/16 ,  G01N33/74 ,  A61K31/519 ,  A61B5/145 ,  G01N33/68 ,  A61P25/18 ,  A61B5/00

CPC分类号： A61B5/167 ,  A61B5/165 ,  A61K31/519 ,  A61P25/18 ,  G01N33/6869 ,  G01N33/6893 ,  G01N33/743 ,  A61B5/14546 ,  A61B5/4088 ,  A61B5/4839 ,  A61B5/7275 ,  G01N2333/5412 ,  G01N2333/7155 ,  G01N2800/302 ,  G01N2800/50 ,  G01N2800/54

摘要： The invention provides methods of identifying schizophrenia patients at risk for relapse. The invention also provides methods of early detection of schizophrenic relapse. The disclosed methods use monitoring of a subset of symptoms and/or one or more biomarkers. The symptom severity can be assessed using the Positive and Negative Syndrome Scale (PANSS) parameters. The methods of the invention can be used to provide early intervention to decrease or prevent relapse in schizophrenia patients.

公开(公告)号：US20230213530A1

公开(公告)日：2023-07-06

申请号：US17855474

申请日：2022-06-30

申请人： INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY

发明人： Jae Min KIM ,  Hee Ju KANG

IPC分类号： G01N33/68

CPC分类号： G01N33/6869 ,  G01N2333/545 ,  G01N2333/5412

摘要： A method for predicting antidepressant treatment response and acute prognosis for depressed patients according to an embodiment of the present disclosure includes measuring a concentration of an antidepressant treatment response prediction biomarker contained in a biological sample of a depressed patient at baseline and determining whether there is an acute phase remission, depending on the measured concentration of the antidepressant treatment response prediction marker.

公开(公告)号：US09983206B2

公开(公告)日：2018-05-29

申请号：US14209746

申请日：2014-03-13

申请人： The Board of Trustees of the University of Illinois

发明人： Ryan C. Bailey ,  Matthew S. Luchansky ,  Abraham J. Qavi ,  Jared T. Kindt

IPC分类号： G01N33/543

CPC分类号： G01N33/54373 ,  G01N2333/5412 ,  G01N2333/55

摘要： Embodiments of the methods, compositions, and systems provided herein relate to enzymatic enhancement of immunoassays using photonic sensor arrays.

公开(公告)号：US20180128820A1

公开(公告)日：2018-05-10

申请号：US15842857

申请日：2017-12-14

申请人： NATIONAL CHENG KUNG UNIVERSITY ,  NATIONAL CHENG KUNG UNIVERSITY HOSPITAL

发明人： WEI-LUN HUANG ,  WU-CHOU SU ,  HAI-WEN CHEN ,  WEI-PANG CHUNG ,  I-TING CHIANG ,  TE-FU YEH ,  HSISHENG TENG ,  LIANG-CHE CHEN

IPC分类号： G01N33/542 ,  G01N33/58

CPC分类号： G01N33/542 ,  G01N33/581 ,  G01N33/588 ,  G01N2333/5412

摘要： A molecular probe includes a detector molecule specific to a target molecule, and at least one label linked covalently or non-covalently to the detector molecule. The label includes a catalyst for generating electrons and/or mediators from a solution. The catalyst includes a nanomaterial, an enzyme, a metal, and/or a metal complex. The mediators can accumulate in the solution for a period of time. The detector molecule and the target molecule interact with each other by a protein based or nucleotide sequence based interaction. The mediators participate in a chemical reaction that generates a signal that may be a change in optical, electromagnetic, thermodynamic or mechanical properties. Generation efficiency of the mediators is enhanced by providing an energy to the solution. The molecular probe may be used with a molecular detection assay performed on a surface. A method for assaying the target molecule using the molecular probe is also provided.

公开(公告)号：US20170196950A1

公开(公告)日：2017-07-13

申请号：US15316372

申请日：2015-06-05

申请人： PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE

发明人： Carolina LLANOS MUNOZ ,  Alexis Mikes KALERGIS PARRA ,  Fabian Alejandro VEGA TAPIA ,  Andy lgor TORRES BAEZA

IPC分类号： A61K39/00 ,  G01N33/569 ,  G01N33/68 ,  C12N5/0784

CPC分类号： A61K39/0008 ,  A61K35/15 ,  A61K2039/5154 ,  A61K2039/577 ,  C12N5/064 ,  C12N2500/92 ,  C12N2500/99 ,  C12N2501/04 ,  C12N2501/22 ,  C12N2501/2304 ,  C12N2501/999 ,  C12N2502/1114 ,  C12N2502/1192 ,  G01N33/56972 ,  G01N33/6869 ,  G01N2333/5412 ,  G01N2333/5434 ,  G01N2333/70503 ,  G01N2333/70532 ,  G01N2333/70539 ,  G01N2333/70578

摘要： The invention relates to a method for producing tolerogenic dendritic cells (tolDCs) with specific antigens, comprising the steps of: (a) culturing precursors of dendritic cells in an animal-serum-free medium, using cytokines, IL-4 and GM-CSF, in order to differentiate same in dendritic cells; (b) producing apoptotic cells; (c) culturing the dendritic cells obtained in step (b) in the presence of compounds having anti-inflammatory activity; (d) co-culturing the dendritic cells from step (d) with the apoptotic cells from step (c), such as to stimulate the endocytosis of the apoptotic cells by the dendritic cells; (e) and, by means of identification based on phenotypic evaluation, determining the production of tolerogenic dendritic cells (tolDCs) with specific antigens. The invention also relates to the tolDC cells produced with said method and to the use of said tolDCs with specific antigens in the production of a drug suitable for the treatment of systemic lupus erythematosus.

公开(公告)号：US20170184611A1

公开(公告)日：2017-06-29

申请号：US15457297

申请日：2017-03-13

申请人： Randox Laboratories Ltd.

发明人： John Lamont ,  Ivan Mc Connell ,  Peter Fitzgerald

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6842 ,  G01N2333/4737 ,  G01N2333/5412 ,  G01N2333/70503 ,  G01N2333/70525 ,  G01N2333/70542 ,  G01N2333/70564 ,  G01N2333/7151 ,  G01N2800/2871 ,  G01N2800/32 ,  G01N2800/60

摘要： The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.