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公开(公告)号：US20210246167A1
公开(公告)日：2021-08-12
申请号：US17236247
申请日：2021-04-21
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US11014965B2
公开(公告)日：2021-05-25
申请号：US16732502
申请日：2020-01-02
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20210283212A1
公开(公告)日：2021-09-16
申请号：US17143232
申请日：2021-01-07
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US10954287B2
公开(公告)日：2021-03-23
申请号：US16093762
申请日：2017-04-14
发明人： Kristopher Josephson , Zhong Ma , Yili Sun , Nathan Ezekiel Nims , Kathleen Seyb , Sylvia Tobe , Ping Ye , Douangsone D. Vadysirisack , Guo-Qing Tang , Douglas A. Treco
IPC分类号： A61K38/00 , C07K14/82 , C07K7/08 , G01N33/574 , A61K47/65 , A61K47/64 , A61P35/00 , A61K47/14 , C07K7/54
摘要： The present invention provides Ras modulators including inhibitors and/or antagonists of Ras, Ras binding, and Ras-dependent cell signaling activity. Also provided are methods of utilizing the Ras modulators as therapeutics.
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公开(公告)号：US20200038477A1
公开(公告)日：2020-02-06
申请号：US16466165
申请日：2017-12-07
发明人： Alonso Ricardo , Steven James DeMarco , Sylvia Tobe , Michelle Denise Hoarty , Robert Paul Hammer , Douglas A. Treco , Kathleen Seyb , Vaishnavi Rajagopal , Guo-Qing Tang , Douangsone D. Vadysirisack , Ramin Farzaneh-Far
IPC分类号： A61K38/12 , A61K9/00 , A61K39/395 , A61P7/06
摘要： The present disclosure relates to polypeptide modulators of complement activity, including cyclic polypeptide modulators. Included are methods of utilizing such modulators as therapeutics. Also provided are methods of measuring C5 and related complexes using C5 binding agents.
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公开(公告)号：US20180371019A1
公开(公告)日：2018-12-27
申请号：US16128561
申请日：2018-09-12
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US10918691B2
公开(公告)日：2021-02-16
申请号：US16776551
申请日：2020-01-30
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US20200155639A1
公开(公告)日：2020-05-21
申请号：US16776551
申请日：2020-01-30
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter
摘要： The present invention provides polypeptide modulators of complement activity, including cyclic polypeptide modulators. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US10435438B2
公开(公告)日：2019-10-08
申请号：US16237893
申请日：2019-01-02
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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公开(公告)号：US10208089B2
公开(公告)日：2019-02-19
申请号：US16128561
申请日：2018-09-12
发明人： Michelle Denise Hoarty , Ketki Ashok Dhamnaskar , Daniel Elbaum , Kristopher Josephson , Kelley Cronin Larson , Zhong Ma , Nathan Ezekiel Nims , Alonso Ricardo , Kathleen Seyb , Guo-Qing Tang , Douglas A. Treco , Zhaolin Wang , Ping Ye , Hong Zheng , Sarah Jacqueline Perlmutter , Robert Paul Hammer
摘要： The present invention provides modulators of complement activity. Also provided are methods of utilizing such modulators as therapeutics.
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