公开(公告)号：US07071004B1

公开(公告)日：2006-07-04

申请号：US09846512

申请日：2001-05-01

申请人： Rachel Meyers ,  Kyle J. Macbeth

发明人： Rachel Meyers ,  Kyle J. Macbeth

IPC分类号： G01N33/53

CPC分类号： A61K38/17 ,  A61K47/6871 ,  A61K51/1075 ,  A61K2039/505 ,  C07K16/40 ,  C12N9/6427 ,  G01N33/573 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57449 ,  G01N2333/96433 ,  G01N2500/00

摘要： The invention provides isolated nucleic acids molecules, designated 14094 nucleic acid molecules, which encode a novel trypsin family member. Elevated expression of 14094 mRNA was detected in breast, ovarian, lung, and liver cancers compared to normal cells derived from these tissues. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 14094 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 14094 gene has been introduced or disrupted. The invention still further provides isolated 14094 proteins, fusion proteins, antigenic peptides and anti-14094 antibodies. Therapeutic and diagnostic methods utilizing compositions of the invention to, for example, treat, prevent, and/or diagnose neoplastic conditions, are also provided.

摘要翻译： 本发明提供编码新型胰蛋白酶家族成员的分离的核酸分子，命名为14094个核酸分子。 与来自这些组织的正常细胞相比，在乳腺癌，卵巢癌，肺癌和肝癌中检测到14094个mRNA的表达升高。 本发明还提供了反义核酸分子，含有14094个核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及14094基因导入或破坏的非人类转基因动物。 本发明还进一步提供了分离的14094蛋白，融合蛋白，抗原肽和抗-144094抗体。 还提供了利用本发明组合例如治疗，预防和/或诊断肿瘤病症的治疗和诊断方法。

公开(公告)号：US20110319355A1

公开(公告)日：2011-12-29

申请号：US13148636

申请日：2010-02-09

申请人： Aaron N. Nguyen ,  Kyle J. Macbeth

发明人： Aaron N. Nguyen ,  Kyle J. Macbeth

IPC分类号： A61K31/706 ,  C07H19/12 ,  A61P35/00

CPC分类号： A61K31/706 ,  A61K31/7068 ,  A61K45/06

摘要： The present disclosure provides methods for treating subjects having non-small cell lung cancer, wherein the methods comprise administering to the subject a cytidine analog, such as 5-azacytidine. Also provided are methods relating to identification and treatment of particular non-small cell lung cancer types sensitive to particular cytidine analogs.

摘要翻译： 本公开提供了用于治疗患有非小细胞肺癌的受试者的方法，其中所述方法包括向受试者施用胞苷类似物，例如5-氮杂胞苷。 还提供了与对特定胞苷类似物敏感的特定非小细胞肺癌类型的鉴定和治疗有关的方法。