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1.发明申请Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use 有权具有至少一个受保护的硫醇区域的白蛋白基胶体组合物，制备方法和使用方法公开(公告)号：US20050187139A1
公开(公告)日：2005-08-25
申请号：US10985798
申请日：2004-11-09
申请人： Ragheb Assaly , J. Dignam , Joseph Shapiro
发明人： Ragheb Assaly , J. Dignam , Joseph Shapiro
CPC分类号： A61K38/38 , A61K38/018
摘要： A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed.
摘要翻译： 公开了一种组合物，其包含具有至少一个被保护的硫醇区域的白蛋白基胶体组合物，其制备方法和使用方法，包括治疗血容量不足的病症如毛细血管渗漏综合征和休克。
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2.发明申请Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use 有权具有至少一个受保护的硫醇区域的白蛋白基胶体组合物，制备方法和使用方法公开(公告)号：US20060057070A1
公开(公告)日：2006-03-16
申请号：US11258646
申请日：2005-10-25
申请人： Ragheb Assaly , J. Dignam , Joseph Shapiro
发明人： Ragheb Assaly , J. Dignam , Joseph Shapiro
CPC分类号： A61K38/38 , A61K47/60 , A61K49/0034 , A61K49/0041 , A61K49/0043 , A61K49/0056
摘要： A composition comprising an albumin-based colloid composition having at least one protected thiol region, method of making the same, and method for use, including treating hypovolemic conditions such as capillary leak syndrome and shock, are disclosed. The composition also is modified with an indicator reagent such as chromophores.
摘要翻译： 公开了一种组合物，其包含具有至少一个被保护的硫醇区域的白蛋白基胶体组合物，其制备方法和使用的方法，包括治疗血容量不足的症状如毛细血管渗漏综合征和休克。 该组合物也用诸如发色团的指示剂进行修饰。
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公开(公告)号：US20080113903A1
公开(公告)日：2008-05-15
申请号：US11982967
申请日：2007-11-06
申请人： Ragheb Assaly , John Dignam , Joseph Shapiro
发明人： Ragheb Assaly , John Dignam , Joseph Shapiro
CPC分类号： A61K38/38
摘要： A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
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公开(公告)号：US20060166886A1
公开(公告)日：2006-07-27
申请号：US11387381
申请日：2006-03-22
申请人： Ragheb Assaly , John Dignam , Joseph Shapiro
发明人： Ragheb Assaly , John Dignam , Joseph Shapiro
IPC分类号： A61K38/38 , A61K31/4025
CPC分类号： A61K38/38 , A61K38/018
摘要： A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
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5.发明申请Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction 审中-公开基于白蛋白的胶体组合物和用于治疗血容量不足和多器官功能障碍的方法公开(公告)号：US20100004178A1
公开(公告)日：2010-01-07
申请号：US12584752
申请日：2009-09-10
申请人： Ragheb Assaly , John D. Dignam , Joseph I. Shapiro
发明人： Ragheb Assaly , John D. Dignam , Joseph I. Shapiro
IPC分类号： A61K38/38 , C07K14/76 , C07K14/765 , C07K14/77
CPC分类号： A61K38/38
摘要： A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
摘要翻译： 公开了一种包含白蛋白基胶体的组合物及其用于治疗低血容量病症如毛细血管渗漏综合征和休克的用途。
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6.发明授权Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction 有权基于白蛋白的胶体组合物和用于治疗血容量不足和多器官功能障碍的方法公开(公告)号：US07348312B2
公开(公告)日：2008-03-25
申请号：US11387381
申请日：2006-03-22
申请人： Ragheb Assaly , John D. Dignam , Joseph I. Shapiro
发明人： Ragheb Assaly , John D. Dignam , Joseph I. Shapiro
IPC分类号： A61K38/38
CPC分类号： A61K38/38 , A61K38/018
摘要： A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
摘要翻译： 公开了一种包含白蛋白基胶体的组合物及其在治疗低血容量病症如毛细血管渗漏综合征和休克中的用途。
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7.发明授权Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction 有权基于白蛋白的胶体组合物和用于治疗血容量不足和多器官功能障碍的方法公开(公告)号：US07605130B2
公开(公告)日：2009-10-20
申请号：US11982967
申请日：2007-11-06
申请人： Ragheb Assaly , John D. Dignam , Joseph I. Shapiro
发明人： Ragheb Assaly , John D. Dignam , Joseph I. Shapiro
IPC分类号： A61K38/38
CPC分类号： A61K38/38
摘要： A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
摘要翻译： 公开了一种包含白蛋白基胶体的组合物及其用于治疗低血容量病症如毛细血管渗漏综合征和休克的用途。
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公开(公告)号：US07037895B2
公开(公告)日：2006-05-02
申请号：US10106793
申请日：2002-03-26
申请人： Ragheb Assaly , John D. Dignam , Joseph I. Shapiro
发明人： Ragheb Assaly , John D. Dignam , Joseph I. Shapiro
IPC分类号： A61K38/38
CPC分类号： A61K38/38 , A61K38/018
摘要： A composition comprising an albumin-based colloid and its use in treating hypovolemic conditions such as capillary leak syndrome and shock are disclosed.
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9.发明申请Peg-albumin composition having at least one protected thiol region as a platform for medications 审中-公开具有至少一个受保护的硫醇区作为药物平台的白蛋白组合物公开(公告)号：US20120010144A1
公开(公告)日：2012-01-12
申请号：US13138558
申请日：2010-04-02
CPC分类号： A61K47/643 , A61K47/60
摘要： This composition comprises a polyethylene glycol-albumin composition having at least one protected thiol region wherein the composition comprises PEG-AlbCys34 with Cys-34 preserved as a thiol. The albumin is linked to medications such as, antioxidants with a reduced sulfhydryl group through the Cys 34 residing on the albumin. The compositions are useful in treating patients.
摘要翻译： 该组合物包含具有至少一个被保护的硫醇区的聚乙二醇 - 白蛋白组合物，其中组合物包含保留为硫醇的Cys-34的PEG-AlbCys34。 白蛋白通过驻留在白蛋白上的Cys 34与药物例如具有降低的巯基的抗氧化剂连接。 该组合物可用于治疗患者。
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