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公开(公告)号:US20080200438A1
公开(公告)日:2008-08-21
申请号:US12065096
申请日:2006-09-07
IPC分类号: A61K31/661 , A61P25/00 , A61K31/137
CPC分类号: A61K45/06 , A61K31/137 , A61K31/661 , A61K2300/00
摘要: Methods of treating various autoimmune diseases, such as multiple sclerosis, peripheral neuritis, optical neuritis, amylotrophic lateral sclerosis, and uveitis utilizing specific amino alcohol derivatives are provided herein.
摘要翻译: 本文提供了使用特定氨基醇衍生物治疗各种自身免疫性疾病如多发性硬化,周围神经炎,光学神经炎,肌营养性侧索硬化和葡萄膜炎的方法。
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公开(公告)号:US20070042948A1
公开(公告)日:2007-02-22
申请号:US10552836
申请日:2004-04-15
申请人: Michael Forstner , Martin Klumpp , Lukas Leder , Barbara Nusslein-Hildesheim , Friedrich Raulf , Gisbert Weckbecker
发明人: Michael Forstner , Martin Klumpp , Lukas Leder , Barbara Nusslein-Hildesheim , Friedrich Raulf , Gisbert Weckbecker
CPC分类号: A61K38/1709 , G01N2333/82 , G01N2500/02
摘要: The present invention provides a method for preventing or treating acute or chronic graft rejection in a recipient of cell, tissue or organ allo- or xenotransplant, inflammatory or autoimmune diseases or malignant proliferative disease, comprising the use of an inhibitor of Vav. Further provided are Vav inhibitors, uses, pharmaceutical compositions and therapeutic combinations comprising Vav inhibitors, and screening methods therefore.
摘要翻译: 本发明提供了一种预防或治疗细胞,组织或器官同种异体或异种移植物,炎性或自身免疫性疾病或恶性增殖性疾病的受体中的急性或慢性移植排斥的方法,其包括使用Vav抑制剂。 进一步提供了Vav抑制剂,用途,药物组合物和包含Vav抑制剂的治疗组合,因此,筛选方法。
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