DNA encoding kainate-binding, human CNS receptors of the EAA5 family
    2.
    发明授权
    DNA encoding kainate-binding, human CNS receptors of the EAA5 family 失效
    编码红藻氨酸结合的DNA,EAA5家族的人类CNS受体

    公开(公告)号:US06322999B1

    公开(公告)日:2001-11-27

    申请号:US08377503

    申请日:1995-01-24

    IPC分类号: C12P2106

    CPC分类号: C07K14/70571 F02B2075/027

    摘要: Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

    摘要翻译: 兴奋性氨基酸(EAAs)如谷氨酸的神经传递通过膜结合表面受体介导。 已经分离了编码红藻氨酸结合型EAA受体的这些受体的一个家族的DNA,并且以受体蛋白为特征。 本文描述了产生作为异源膜结合产物的EAA受体的重组细胞系。 还描述了具有商业意义的本发明的相关方面。 包括使用细胞系作为发现调节EAA受体刺激的化合物的工具。

    AMPA-binding human GluR2 receptors
    5.
    发明授权
    AMPA-binding human GluR2 receptors 失效
    AMPA结合人GluR2受体

    公开(公告)号:US06399313B1

    公开(公告)日:2002-06-04

    申请号:US08439946

    申请日:1995-05-12

    IPC分类号: G01N3353

    CPC分类号: C07K14/70571 C07K14/705

    摘要: Described herein are isolated polynucleotides which code for an AMPA-type human CNS receptor, designated the human GluR2B receptor. The receptor is characterized structurally and the construction and use of cell lines expressing these receptor is disclosed.

    摘要翻译: 本文描述的是编码AMPA型人CNS受体的分离的多核苷酸,其命名为人GluR2B受体。 该受体的结构特征在于,公开了表达这些受体的细胞系的构建和用途。

    Kainate-binding, human CNS receptors of the EAA4 family
    6.
    发明授权
    Kainate-binding, human CNS receptors of the EAA4 family 失效
    胭脂红蛋白结合,EAA4家族的人CNS受体

    公开(公告)号:US06376200B1

    公开(公告)日:2002-04-23

    申请号:US08249241

    申请日:1994-05-25

    IPC分类号: G01N33567

    CPC分类号: C07K14/70571

    摘要: Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

    摘要翻译: 兴奋性氨基酸(EAAs)如谷氨酸的神经传递通过膜结合表面受体介导。 已经分离了编码红藻氨酸结合型EAA受体的这些受体的一个家族的DNA,并且以受体蛋白为特征。 本文描述了产生作为异源膜结合产物的EAA受体的重组细胞系。 还描述了具有商业意义的本发明的相关方面。 包括使用细胞系作为发现调节EAA受体刺激的化合物的工具。

    Kainate-binding, human CNS receptors of the EAA5 family
    9.
    发明授权
    Kainate-binding, human CNS receptors of the EAA5 family 失效
    胭脂红蛋白结合,EAA5家族的人CNS受体

    公开(公告)号:US06333161B1

    公开(公告)日:2001-12-25

    申请号:US08178019

    申请日:1994-01-06

    IPC分类号: C12N1563

    CPC分类号: C07K14/70571 F02B2075/027

    摘要: Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.

    摘要翻译: 兴奋性氨基酸(EAAs)如谷氨酸的神经传递通过膜结合表面受体介导。 已经分离了编码红藻氨酸结合型EAA受体的这些受体的一个家族的DNA,并且以受体蛋白为特征。 本文描述了产生作为异源膜结合产物的EAA受体的重组细胞系。 还描述了具有商业意义的本发明的相关方面。 包括使用细胞系作为发现调节EAA受体刺激的化合物的工具。