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公开(公告)号：US6024981A
公开(公告)日：2000-02-15
申请号：US57884
申请日：1998-04-09
CPC分类号： A61K9/0007 , A61K9/0056 , A61K9/2018 , Y10S514/951 , Y10S514/96
摘要： The invention is directed to a hard tablet that can be stored, packaged and processed in bulk. Yet the tablet dissolves rapidly in the mouth of the patient with a minimum of grit. The tablet is created from an active ingredient mixed into a matrix of a non-direct compression filler and a relatively high lubricant content.
摘要翻译： 本发明涉及可以批量储存，包装和加工的硬片。 然而，片剂以最少的砂砾迅速溶解在患者的口中。 片剂由混合成非直接压缩填料的基质和较高润滑剂含量的活性成分制成。
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公开(公告)号：US06221392B1
公开(公告)日：2001-04-24
申请号：US09464882
申请日：1999-12-16
IPC分类号： A61K920
CPC分类号： A61K9/0007 , A61K9/0056 , A61K9/2018 , Y10S514/951 , Y10S514/96
摘要： The invention is directed to a hard tablet that can be stored, packaged and processed in bulk. Yet the tablet dissolves rapidly in the mouth of the patient with a minimum of grit. The tablet is created from an active ingredient mixed into a matrix of a nondirect compression filler and a relatively high lubricant content.
摘要翻译： 本发明涉及可以批量储存，包装和加工的硬片。 然而，片剂以最少的砂砾迅速溶解在患者的口中。 片剂由混合成非直接压缩填料的基质和较高润滑剂含量的活性成分制成。
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3.发明授权公开(公告)号：US06365182B1
公开(公告)日：2002-04-02
申请号：US09132837
申请日：1998-08-12
IPC分类号： A61K946
CPC分类号： A61K33/14 , A61K9/0007 , A61K9/0056 , A61K9/2018 , A61K9/2081
摘要： The present invention relates to a potassium containing dosage form which is capable of rapidly disintegrating in a patient's mouth to form an easy to swallow slurry.
摘要翻译： 本发明涉及一种含钾剂型，其能够在患者口中快速崩解以形成容易吞咽的浆液。
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公开(公告)号：US06200604B1
公开(公告)日：2001-03-13
申请号：US09327814
申请日：1999-06-08
申请人： Sathasivan Indiran Pather , Rajendra K. Khankari , Jonathan D. Eichman , Joseph R. Robinson , John Hontz
发明人： Sathasivan Indiran Pather , Rajendra K. Khankari , Jonathan D. Eichman , Joseph R. Robinson , John Hontz
IPC分类号： A61K946
CPC分类号： A61K31/5415 , A61K9/0007 , A61K9/0056 , A61K9/006 , A61K31/4468
摘要： A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
摘要翻译： 一种药物剂型，其适于向口腔中提供药物的颊，舌下或牙龈吸收，所述药物包含与用于促进药物在口腔中吸收的口腔可药用组合泡腾剂。 还公开了与泡腾剂结合使用另外的pH调节物质以促进吸收药物。
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公开(公告)号：US08728441B2
公开(公告)日：2014-05-20
申请号：US13098986
申请日：2011-05-02
申请人： Jonathan D. Eichman , John Hontz , Rajendra K. Khankari , Sathasivan Indiran Pather , Joseph R. Robinson
发明人： Jonathan D. Eichman , John Hontz , Rajendra K. Khankari , Sathasivan Indiran Pather , Joseph R. Robinson
CPC分类号： A61K31/4468 , A61K9/0007 , A61K9/0056 , A61K9/006 , A61K31/5415
摘要： A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
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公开(公告)号：US06740341B1
公开(公告)日：2004-05-25
申请号：US09449851
申请日：1999-11-24
申请人： Kris E. Holt , Rajendra K. Khankari , John Hontz
发明人： Kris E. Holt , Rajendra K. Khankari , John Hontz
IPC分类号： A61K914
CPC分类号： A61K9/0056 , A61K9/5073 , Y10S514/974
摘要： The present invention relates to a core containing a drug encased in a spacing layer and a taste masking layer which provides effective taste masking for in-mouth disintegrable dosage forms containing highly objectionable tasting drugs, as well as dosage forms containing these cores.
摘要翻译： 本发明涉及含有间隔层中的药物的核心和掩味层，其对含有高度令人讨厌的品尝药物的口腔内可分解剂型以及含有这些核心的剂型提供有效的掩味。
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公开(公告)号：US06576250B1
公开(公告)日：2003-06-10
申请号：US09664870
申请日：2000-09-19
申请人： S. Indiran Pather , Joseph R. Robinson , Jonathan D. Eichman , Rajendra K. Khankari , John Hontz
发明人： S. Indiran Pather , Joseph R. Robinson , Jonathan D. Eichman , Rajendra K. Khankari , John Hontz
IPC分类号： A61K902
CPC分类号： A61K9/006 , A61K9/0007 , A61K9/0056 , A61K9/2072 , A61K9/2866 , A61K9/2886 , A61K31/4468 , A61K31/5415
摘要： The pharmaceutical compositions of the present invention comprise rectally and vaginally administerable dosage forms that contain effervescent agents as penetration enhancers for drugs. Effervescence occurs in the rectum or vagina, once the dosage form is administered or at a predetermined time following administration. The effervescent agents can be used alone or in combination with pH adjusting substance, which further promote dissolution and absorption of the active ingredient.
摘要翻译： 本发明的药物组合物包含含有泡腾剂作为药物渗透促进剂的直肠和阴道给药剂型。 在直肠或阴道中发生泡腾，一旦施用剂型或在施用后的预定时间。 泡腾剂可以单独使用或与pH调节物质组合使用，这进一步促进活性成分的溶解和吸收。
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公开(公告)号：US08753611B2
公开(公告)日：2014-06-17
申请号：US13099003
申请日：2011-05-02
申请人： Jonathan D. Eichman , John Hontz , Rajendra K. Khankari , Sathasivan Indiran Pather , Joseph R. Robinson
发明人： Jonathan D. Eichman , John Hontz , Rajendra K. Khankari , Sathasivan Indiran Pather , Joseph R. Robinson
CPC分类号： A61K31/4468 , A61K9/0007 , A61K9/0056 , A61K9/006 , A61K31/5415
摘要： A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
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公开(公告)号：US20110212034A1
公开(公告)日：2011-09-01
申请号：US13098986
申请日：2011-05-02
申请人： Sathasivan Indiran Pather , Rajendra K. Khankari , Jonathan D. Eichman , Joseph R. Robinson , John Hontz
发明人： Sathasivan Indiran Pather , Rajendra K. Khankari , Jonathan D. Eichman , Joseph R. Robinson , John Hontz
IPC分类号： A61K31/495 , A61P25/04
CPC分类号： A61K31/4468 , A61K9/0007 , A61K9/0056 , A61K9/006 , A61K31/5415
摘要： A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.
摘要翻译： 一种药物剂型，其适于向口腔中提供药物的口腔，舌下或牙龈吸收，所述药物包含与可用于促进所述药物在口腔中的吸收的泡腾剂相结合的可口服给药的药物。 还公开了与泡腾剂结合使用另外的pH调节物质以促进吸收药物。
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公开(公告)号：US06764696B2
公开(公告)日：2004-07-20
申请号：US10346829
申请日：2003-03-18
申请人： S. Indiran Pather , Joseph R. Robinson , Jonathan D. Eichman , Rajendra K. Khankari , John Hontz , Sangeeta V. Gupte
发明人： S. Indiran Pather , Joseph R. Robinson , Jonathan D. Eichman , Rajendra K. Khankari , John Hontz , Sangeeta V. Gupte
IPC分类号： A61K924
CPC分类号： A61K9/2886 , A61K9/0007 , A61K9/2072 , A61K9/2866 , A61K9/5084 , Y10S514/96
摘要： The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.
摘要翻译： 本发明的药物组合物包含口服给药剂型，其使用泡腾作为已知或怀疑具有差的生物利用度的药物的渗透增强剂。 一旦片剂或其他剂型被摄取，起泡可能发生在胃中。 除了在胃中起泡或作为替代技术，通过使用适当的包衣和其它技术，泡腾可以发生在胃肠道的其它部分，包括但不限于食道，十二指肠和结肠。 选择泡腾和药物释放的部位以与显示配制药物的最大吸收的胃肠道的部分相对应，或获得一些其他治疗优势。
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