公开(公告)号：US20120165320A1

公开(公告)日：2012-06-28

申请号：US13380744

申请日：2010-06-22

申请人： Rajseh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Gurmeet Kaur ,  Sandeep Kanwar ,  Nishan Singh ,  Gurmeet Kaur Nanda ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

发明人： Rajseh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Gurmeet Kaur ,  Sandeep Kanwar ,  Nishan Singh ,  Gurmeet Kaur Nanda ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

IPC分类号： A61K31/422 ,  C07D413/14 ,  A61K31/4439 ,  A61K31/5377 ,  A61P25/00 ,  A61K31/403 ,  C07D417/10 ,  A61K31/541 ,  A61K31/551 ,  A61K31/5513 ,  C07D413/10 ,  C07D403/10

CPC分类号： C07D221/22 ,  C07D209/52 ,  C07D401/10 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08

摘要： The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof.

摘要翻译： 本发明涉及式I的新化合物，其药学上可接受的衍生物，互变异构体，立体异构体，包括R和S异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。

公开(公告)号：US08906913B2

公开(公告)日：2014-12-09

申请号：US13380744

申请日：2010-06-22

申请人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Gurmeet Kaur ,  Sandeep Kanwar ,  Nishan Singh ,  Gurmeet Kaur Nanda ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

发明人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Gurmeet Kaur ,  Sandeep Kanwar ,  Nishan Singh ,  Gurmeet Kaur Nanda ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

IPC分类号： A61K31/5355 ,  C07D413/10 ,  C07D209/52 ,  C07D417/14 ,  C07D491/08 ,  C07D221/22 ,  C07D487/04 ,  C07D413/14 ,  C07D409/04 ,  C07D471/04 ,  C07D417/10 ,  C07D401/10

CPC分类号： C07D221/22 ,  C07D209/52 ,  C07D401/10 ,  C07D409/04 ,  C07D413/10 ,  C07D413/14 ,  C07D417/10 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/08

摘要： The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof.

摘要翻译： 本发明涉及式I的新化合物，其药学上可接受的衍生物，互变异构体，立体异构体，包括R和S异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成式I的新化合物，其药学上可接受的衍生物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。

公开(公告)号：US20110245258A1

公开(公告)日：2011-10-06

申请号：US13130440

申请日：2009-11-18

申请人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Sandeep Kanwar ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

发明人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Sandeep Kanwar ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61K31/519 ,  A61P31/04 ,  A61P31/16 ,  A61P31/06

CPC分类号： C07D487/04 ,  C07D263/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.

摘要翻译： 本发明涉及式I的新型苯基恶唑烷酮化合物，其药学上可接受的类似物，互变异构形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成新型式I化合物或其药学上可接受的类似物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。 本发明还提供了包含新颖的式I化合物和使用它们的方法的药物组合物。 本发明的化合物可用作抗微生物剂，对许多需氧和/或厌氧革兰氏阳性和/或革兰氏阴性病原体有效，如葡萄球菌，链球菌，肠球菌，细菌，梭菌，流感嗜血杆菌 ，莫拉氏菌，耐酸菌，如结核分枝杆菌，以及耐盐霉菌属的霉菌和肠球菌。

公开(公告)号：US08841306B2

公开(公告)日：2014-09-23

申请号：US13130440

申请日：2009-11-18

申请人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Sandeep Kanwar ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

发明人： Rajesh Jain ,  Sanjay Trehan ,  Jagattaran Das ,  Sandeep Kanwar ,  Sitaram Kumar Magadi ,  Sudhir Kumar Sharma

IPC分类号： A61K31/33 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D413/12 ,  C07D263/20

CPC分类号： C07D487/04 ,  C07D263/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

摘要： The present invention relates to novel phenyl oxazolidinone compounds of formula I, their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of formula I or their pharmaceutically acceptable analogs, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of formula I and methods of using them. The compounds of the present invention are useful as antimicrobial agents, effective against a number of aerobic and/or anaerobic Gram positive and/or Gram negative pathogens such as multi drug resistant species of Staphylococcus, Streptococcus, Enterococcus, Bacterioides, Clostridia, H. influenza, Moraxella, acid-fast organisms such as Mycobacterium tuberculosis as well as Linezolid resistant species of Staphylococcus and Enterococcus.

摘要翻译： 本发明涉及式I的新型苯基恶唑烷酮化合物，其药学上可接受的类似物，互变异构形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂化物。 本发明还涉及合成新型式I化合物或其药学上可接受的类似物，互变异构体形式，立体异构体，多晶型物，前药，代谢物，盐或溶剂合物的方法。 本发明还提供了包含新颖的式I化合物和使用它们的方法的药物组合物。 本发明的化合物可用作抗微生物剂，对许多需氧和/或厌氧革兰氏阳性和/或革兰氏阴性病原体有效，如葡萄球菌，链球菌，肠球菌，细菌，梭菌，流感嗜血杆菌 ，莫拉氏菌，耐酸菌，如结核分枝杆菌，以及耐盐霉菌属的霉菌和肠球菌。