公开(公告)号：US20080138347A1

公开(公告)日：2008-06-12

申请号：US11866369

申请日：2007-10-02

Applicant: Ralf M. LUCHE ,  Bo WEI

Inventor： Ralf M. LUCHE ,  Bo WEI

IPC: A61K39/00 ,  C07K16/00 ,  G01N33/53 ,  C12Q1/68 ,  C12N5/04 ,  A61K38/00

CPC classification number: C12Q1/42 ,  A61K38/00 ,  C12N9/16 ,  C12Y301/03016 ,  C12Y301/03048 ,  G01N33/573 ,  G01N2500/04

Abstract: Compositions and methods are provided for the treatment of conditions associated with cell proliferation, cell differentiation and cell survival. In particular, the dual-specificity phosphatase DSP-10, and polypeptide variants thereof that stimulate dephosphorylation of DSP-10 substrates, are provided. The polypeptides may be used, for example, to identify antibodies and other agents that inhibit DSP-10 activity. The polypeptides and agents may be used to modulate cell proliferation, differentiation, and survival.

Abstract translation: 提供组合物和方法用于治疗与细胞增殖，细胞分化和细胞存活相关的病症。 特别地，提供了刺激DSP-10底物去磷酸化的双特异性磷酸酶DSP-10及其多肽变体。 多肽可用于例如鉴定抑制DSP-10活性的抗体和其它试剂。 多肽和试剂可用于调节细胞增殖，分化和存活。