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公开(公告)号：US20120316324A1
公开(公告)日：2012-12-13
申请号：US13498017
申请日：2010-09-24
申请人： Ralph Adams , Laura Hancock , Sam Phillip Heywood
发明人： Ralph Adams , Laura Hancock , Sam Phillip Heywood
摘要： A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab′ fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest which are a VH/VL pair, wherein the two single domain antibodies are linked by a disulfide bond. Also provided are particular dual specificity antibody fusion proteins and other antibody fragments which are stabilised by a disulfide bond.
摘要翻译： 一种多价抗体融合蛋白，其包含免疫球蛋白部分，例如Fab或Fab'片段，对感兴趣的抗原具有第一特异性，并且还包含对于目标第二抗原具有特异性的两个单结构域抗体（dAb） VH / VL对，其中两个单结构域抗体通过二硫键连接。 还提供了通过二硫键稳定的特异性双特异性抗体融合蛋白和其他抗体片段。
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公开(公告)号：US20110184152A1
公开(公告)日：2011-07-28
申请号：US13121055
申请日：2009-09-25
申请人： Ralph Adams , Laura Hancock , Sam Philip Heywood
发明人： Ralph Adams , Laura Hancock , Sam Philip Heywood
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/18 , C07K16/245 , C07K16/28 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/62 , C07K2317/624 , C07K2317/92
摘要： A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab′ fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab′ fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.
摘要翻译： 一种多价抗体融合蛋白，其包含免疫球蛋白部分，例如Fab或Fab'片段，对感兴趣的抗原具有第一特异性，并且还包含对感兴趣的第二抗原具有特异性的两个单结构域抗体（dAb），其中 两个单结构域抗体通过二硫键连接。 还提供了特异的双重特异性抗体融合蛋白，其包含Fab或Fab'片段和一个或多个单结构域抗体，其可以通过它们之间的二硫键来稳定。
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公开(公告)号：US10407513B2
公开(公告)日：2019-09-10
申请号：US13121055
申请日：2009-09-25
申请人： Ralph Adams , Laura Hancock , Sam Philip Heywood
发明人： Ralph Adams , Laura Hancock , Sam Philip Heywood
摘要： A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab′ fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab′ fragment and one or more single domain antibodies which may be stabilized by a disulfide bond therebetween.
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