公开(公告)号：US20250099503A1

公开(公告)日：2025-03-27

申请号：US18729713

申请日：2023-01-25

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Adi BARZEL ,  Alessio D. NAHMAD ,  Rashad TARADI

IPC: A61K35/17 ,  A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/715 ,  C07K14/725 ,  C07K16/10 ,  C07K16/32 ,  C12N5/0781

Abstract: The present disclosure describes a chimeric antigen receptors (CAR) that allow a cell of the B cell lineage to undergo antigen-induced activation independent of a cell of T cell lineage, compositions thereof, and method of use thereof for genetically modifying a cell of the B cell lineage or treating a subject suffering from a pathological disorder.

公开(公告)号：US20210269771A1

公开(公告)日：2021-09-02

申请号：US17200357

申请日：2021-03-12

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Adi BARZEL ,  Alessio D. NAHMAD ,  Tal AKRIV ,  Miriam FRIED ,  Iris DOTAN ,  Daniel NATAF

IPC: C12N5/0781 ,  C12N15/85 ,  C12N15/90 ,  C07K16/00 ,  C07K14/705 ,  A61K35/17 ,  C07K16/10

Abstract: The present invention relates to methods and compositions for engineering B cells to express transgenic B cell receptor (BCR) for antigen-induced antibody secretion, compositions, methods and uses thereof in immunotherapy.