公开(公告)号：US11104651B2

公开(公告)日：2021-08-31

申请号：US16920710

申请日：2020-07-05

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Gerardo Zelmar Lederkremer ,  Julia Leitman ,  Hagit Eiger ,  Daniel Offen ,  Javier Ganz ,  Moshe Portnoy

IPC: A61K45/06 ,  A61K31/505 ,  A61P25/00 ,  C07D239/42

Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.

公开(公告)号：US10723706B2

公开(公告)日：2020-07-28

申请号：US16066697

申请日：2017-06-13

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Gerardo Zelmar Lederkremer ,  Julia Leitman ,  Hagit Eiger ,  Daniel Offen ,  Javier Ganz ,  Moshe Portnoy

IPC: C07D239/42 ,  A61K45/06 ,  A61K31/505 ,  A61P25/00

Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.