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1.
公开(公告)号:US11104651B2
公开(公告)日:2021-08-31
申请号:US16920710
申请日:2020-07-05
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Gerardo Zelmar Lederkremer , Julia Leitman , Hagit Eiger , Daniel Offen , Javier Ganz , Moshe Portnoy
IPC: A61K45/06 , A61K31/505 , A61P25/00 , C07D239/42
Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.
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2.
公开(公告)号:US10723706B2
公开(公告)日:2020-07-28
申请号:US16066697
申请日:2017-06-13
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Gerardo Zelmar Lederkremer , Julia Leitman , Hagit Eiger , Daniel Offen , Javier Ganz , Moshe Portnoy
IPC: C07D239/42 , A61K45/06 , A61K31/505 , A61P25/00
Abstract: Compounds represented by Formula I are disclosed herein, wherein R, Ra and R1-R14 are as defined herein. Further disclosed are uses and methods utilizing said compounds for use in inhibiting an activity of PERK, and in treating a disease or disorder associated with aggregation-prone proteins, a disease or disorder in which downregulating an unfolded protein response is beneficial, and/or Huntington's disease.
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