公开(公告)号：US08558011B2

公开(公告)日：2013-10-15

申请号：US12872866

申请日：2010-08-31

申请人： Raymond W Colburn ,  Scott L Dax ,  Christopher Flores ,  Jay M Matthews

发明人： Raymond W Colburn ,  Scott L Dax ,  Christopher Flores ,  Jay M Matthews

IPC分类号： C07D333/72

CPC分类号： C07F9/65517 ,  C07F9/5728 ,  C07F9/655354 ,  C07F9/65586 ,  C07F9/6561

摘要： The invention is directed to TRPM8 antagonists of Formula (I). More specifically, the present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and methods for treating TRPM8-mediated disorders. Pharmaceutical and veterinary compositions and methods of treating pain and various other disease states or conditions using compounds of the invention are also described.