公开(公告)号：US20090076064A1

公开(公告)日：2009-03-19

申请号：US12159993

申请日：2007-01-03

申请人： Rebecca Urbanek ,  Dean Brown ,  Gary Steelman ,  William Blackwell ,  Steven Wesolowski ,  Xia Wang

发明人： Rebecca Urbanek ,  Dean Brown ,  Gary Steelman ,  William Blackwell ,  Steven Wesolowski ,  Xia Wang

IPC分类号： A61K31/439 ,  C07D471/08 ,  C07D401/12 ,  A61K31/4545

CPC分类号： C07D405/12 ,  C07D401/12 ,  C07D413/12 ,  C07D451/06

摘要： Disclosed are compounds of Formula (I) wherein G, R2, A, D and E are as described in the specification, or pharmaceutically-acceptable salts, or in vivo-hydrolysable precursors thereof. Also disclosed herein is at least one method of making, at least one pharmaceutical composition containing, and at least one method for using at least one compound in accordance with Formula I.

摘要翻译： 公开了式（I）的化合物，其中G，R 2，A，D和E如说明书中所述，或其药学上可接受的盐或其体内可水解的前体。 本文还公开了至少一种制备至少一种药物组合物的方法，所述至少一种药物组合物含有和至少一种使用至少一种根据式I的化合物的方法。

公开(公告)号：US20080269275A1

公开(公告)日：2008-10-30

申请号：US11914400

申请日：2006-05-29

申请人： Dean Brown ,  William Blackwell ,  Frances M. McLaren ,  Volker Schnecke ,  Reed W. Smith ,  Gary Steelman ,  Xia Wang ,  Rebecca Urbanek ,  Steven Wesolowski

发明人： Dean Brown ,  William Blackwell ,  Frances M. McLaren ,  Volker Schnecke ,  Reed W. Smith ,  Gary Steelman ,  Xia Wang ,  Rebecca Urbanek ,  Steven Wesolowski

IPC分类号： A61K31/439 ,  C07D471/08 ,  C07D211/06 ,  A61K31/445

CPC分类号： C07D409/12 ,  C07D211/46 ,  C07D295/135 ,  C07D405/04 ,  C07D451/06

摘要： Compounds of Formula I wherein R1, D, R2, A and R3 are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods for using the same.

摘要翻译： 其中R 1，D 2，R 2，A和R 3的式I化合物如说明书中所述，药学上可接受的盐， 制备方法，药物组合物及其使用方法。

公开(公告)号：US06448562B1

公开(公告)日：2002-09-10

申请号：US09363955

申请日：1999-07-29

申请人： William A. Seidler ,  Muamer Zukic ,  Edward L. Fry ,  Charles H. Hill ,  William Blackwell

发明人： William A. Seidler ,  Muamer Zukic ,  Edward L. Fry ,  Charles H. Hill ,  William Blackwell

IPC分类号： G01T100

CPC分类号： G01T3/00

摘要： A remote sensor for detecting a nuclear source, comprises: a Field-of-View (FOV) structure having an aperture therethrough of area A and a Field-of-View (FOV) angle, the FOV angle centered on a source, and subtending a solid angle &OHgr; to the nuclear source; a plurality of optical filters for filtering photons outside a selected Ultraviolet (UV) band and for transmitting in-band photons according to a selected Transfer Function defining an out-of-band rejection ratio and an in-band transmittance ratio for the selected UV band, the Transfer Function supporting a sensor sensitivity S at the selected UV band for the Field-of-View (FOV) structure to support a Signal-to-Noise ratio of greater than one (1) to detect a nuclear source of nuclear material having a brightness of at least about IR, the selected UV band being selected such that naturally occurring in-band photons are at a brightness of about less than 104 R during daylight and are not naturally occurring at night up to about 20 km Earth altitude, and the in-band photons have a mean free path in air large enough and a radiative emission rate short enough to allow the in-band photons to reach the Field-of-View structure; and an optical camera having pixels configured to receive the in-band photons transmitted through the optical filters for measuring the in-band photons, the in-band photons being emitted from airglow caused by ionizing radiation from the nuclear material.

摘要翻译： 一种用于检测核源的远程传感器，包括：视场（FOV）结构，其具有通过其区域A和视场（FOV）角的孔径，以源为中心的FOV角和对准 OMEGA对核源的立体角; 多个滤光器，用于过滤所选紫外线（UV）波段外的光子，并根据所选择的传输函数传输带内光子，所述传输函数定义了所选UV带的带外抑制比和带内透射比 ，传递函数支持在视场（FOV）结构的所选UV带处的传感器灵敏度S，以支持大于1（1）的信噪比来检测具有 至少约IR的亮度，所选择的UV带被选择为使得天然存在的带内光子在日光期间处于大约小于104R的亮度，并且在夜间高达约20km的地球高度处天然不发生，以及 带内光子具有足够大的空气中的平均自由路径，并且辐射发射速率足够短以允许带内光子达到视场结构; 以及具有被配置为接收通过光学滤波器传输的带内光子的像素的光学摄像机，用于测量带内光子，该带内光子从由核材料的电离辐射引起的气泡发射。