公开(公告)号：US20200283501A1

公开(公告)日：2020-09-10

申请号：US16758142

申请日：2018-10-26

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： Jianming Wu ,  Bruce Kenneth Walcheck ,  Robert Harrison Hullsiek ,  Yungfang Li ,  Hemant Kumar Mishra

IPC分类号： C07K14/735 ,  C12N5/0783 ,  C07K16/30

摘要： A recombinant immune cell expresses a heterologous IgG Fc receptor. In some embodiments, the heterologous IgG Fc receptor can be a chimeric IgG Fc receptor. Generally, the chimeric IgG Fc receptor includes an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain generally includes a sufficient portion of CD64 to bind to an IgG Fc region. The intracellular domain of the chimeric IgG Fc receptor includes a sufficient portion of an Fc receptor allowing immunoreceptor tyrosine-based activation motif (ITAM) to initiate cell signaling when an IgG Fc region binds to the extracellular domain.

公开(公告)号：US20240124550A1

公开(公告)日：2024-04-18

申请号：US18474781

申请日：2023-09-26

申请人： Regents of the University of Minnesota

发明人： Jianming Wu ,  Bruce Kenneth Walcheck ,  Robert Harrison Hullsiek ,  Yungfang Li ,  Hemant Kumar Mishra

IPC分类号： C07K14/735 ,  C07K16/30 ,  C12N5/0783

CPC分类号： C07K14/70535 ,  C07K16/30 ,  C12N5/0646 ,  C07K2317/24 ,  C07K2319/74

摘要： A recombinant immune cell expresses a heterologous IgG Fc receptor. In some embodiments, the heterologous IgG Fc receptor can be a chimeric IgG Fc receptor. Generally, the chimeric IgG Fc receptor includes an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain generally includes a sufficient portion of CD64 to bind to an IgG Fc region. The intracellular domain of the chimeric IgG Fc receptor includes a sufficient portion of an Fc receptor allowing immunoreceptor tyrosine-based activation motif (ITAM) to initiate cell signaling when an IgG Fc region binds to the extracellular domain.