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公开(公告)号：US20120039817A1
公开(公告)日：2012-02-16
申请号：US13281726
申请日：2011-10-26
申请人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
CPC分类号： A61K9/008 , A61K9/124 , A61K31/138 , A61K31/167 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/58 , A61K45/06 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
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2.发明申请COMPOSITIONS, METHODS & SYSTEMS FOR RESPIRATORY DELIVERY OF TWO OR MORE ACTIVE AGENTS 有权组合物，两种或更多活性剂的呼吸输送方法和系统公开(公告)号：US20120039952A1
公开(公告)日：2012-02-16
申请号：US13109884
申请日：2011-05-17
申请人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
IPC分类号： A61K9/12 , A61P11/00 , A61P11/08 , A61K9/00 , A61P29/00 , A61P9/12 , A61P9/08 , A61P11/06 , A61P37/08
CPC分类号： A61K9/008 , A61K9/124 , A61K31/138 , A61K31/167 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/58 , A61K45/06 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送两种或多种活性剂。 在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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3.发明授权Compositions, methods and systems for respiratory delivery of two or more active agents 有权用于呼吸递送两种或多种活性剂的组合物，方法和系统公开(公告)号：US08815258B2
公开(公告)日：2014-08-26
申请号：US13109884
申请日：2011-05-17
申请人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
IPC分类号： A61K9/00
CPC分类号： A61K9/008 , A61K9/124 , A61K31/138 , A61K31/167 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/58 , A61K45/06 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送两种或多种活性剂。 在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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4.发明授权Compositions, methods and systems for respiratory delivery of two or more active agents 有权用于呼吸递送两种或多种活性剂的组合物，方法和系统公开(公告)号：US08324266B2
公开(公告)日：2012-12-04
申请号：US13281726
申请日：2011-10-26
申请人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
CPC分类号： A61K9/008 , A61K9/124 , A61K31/138 , A61K31/167 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/58 , A61K45/06 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送两种或多种活性剂。 在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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5.发明申请COMPOSITIONS, METHODS & SYSTEMS FOR RESPIRATORY DELIVERY OF TWO OR MORE ACTIVE AGENTS 审中-公开组合物，两种或更多活性剂的呼吸输送方法和系统公开(公告)号：US20110132357A1
公开(公告)日：2011-06-09
申请号：US12790710
申请日：2010-05-28
申请人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , David Lechuga-Ballesteros , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送两种或多种活性剂。 在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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6.发明申请COMPOSITIONS FOR RESPIRATORY DELIVERY OF ACTIVE AGENTS AND ASSOCIATED METHODS AND SYSTEMS 审中-公开用于呼吸传递活性药剂和相关方法和系统的组合物公开(公告)号：US20110135737A1
公开(公告)日：2011-06-09
申请号：US12790671
申请日：2010-05-28
申请人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary or nasal delivery of active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统用于通过计量剂量吸入器肺或鼻递送活性剂。 在一个实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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7.发明申请COMPOSITIONS FOR PULMONARY DELIVERY OF LONG-ACTING B2 ADRENERGIC RECEPTOR AGONISTS AND ASSOCIATED METHODS AND SYSTEMS 有权用于长时间输送B2活性受体激动剂和相关方法和系统的组合物公开(公告)号：US20110132356A1
公开(公告)日：2011-06-09
申请号：US12790605
申请日：2010-05-28
申请人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting β2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统，用于经由计量吸入器肺部递送长效毒蕈碱拮抗剂和长效二肾上腺素能受体激动剂。 在具体实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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8.发明授权Compositions for pulmonary delivery of long-acting muscarinic antagonists and associated methods and systems 有权用于肺部输送长效毒蕈碱拮抗剂及其相关方法和系统的组合物公开(公告)号：US09463161B2
公开(公告)日：2016-10-11
申请号：US12790448
申请日：2010-05-28
申请人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
IPC分类号： A61K9/14 , A61K31/58 , A61P11/00 , A61K9/12 , A61K9/00 , A61K31/137 , A61K31/167 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/135 , A61K31/16 , A61K31/192 , A61K31/194
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting β2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统用于通过计量吸入器肺部递送长效毒蕈碱拮抗剂和长效β2肾上腺素能受体激动剂。 在具体实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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9.发明授权Compositions for pulmonary delivery of long-acting β2 adrenergic receptor agonists and associated methods and systems 有权用于肺部输送长效和二肾上腺素受体激动剂及其相关方法和系统的组合物公开(公告)号：US08808713B2
公开(公告)日：2014-08-19
申请号：US12790605
申请日：2010-05-28
申请人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting β2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统，用于经由计量吸入器肺部递送长效毒蕈碱拮抗剂和长效二肾上腺素能受体激动剂。 在具体实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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10.发明申请公开(公告)号：US20110023876A1
公开(公告)日：2011-02-03
申请号：US12790448
申请日：2010-05-28
申请人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
发明人： Reinhard Vehring , Michael Steven Hartman , Adrian Edward Smith , Vidya B. Joshi , Sarvajna Kumar Dwivedi
CPC分类号： A61K9/008 , A61K9/1611 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/40 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61M15/0065 , A61K2300/00
摘要： Compositions, methods and systems are provided for pulmonary delivery of long-acting muscarinic antagonists and long-acting β2 adrenergic receptor agonists via a metered dose inhaler. In particular embodiments, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.
摘要翻译： 提供组合物，方法和系统，用于经由计量吸入器肺部递送长效毒蕈碱拮抗剂和长效二肾上腺素能受体激动剂。 在具体实施方案中，组合物包括悬浮介质，活性剂颗粒和悬浮颗粒，其中活性剂颗粒和悬浮颗粒在悬浮介质中形成共悬浮液。
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