公开(公告)号：US20190169342A1

公开(公告)日：2019-06-06

申请号：US16271296

申请日：2019-02-08

申请人： Relypsa, Inc.

发明人： Inez Lees ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Hongmin Zhang ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao ,  Xinnan Zhang

IPC分类号： C08F226/06 ,  C08G73/06 ,  C08G73/02 ,  A61K31/155 ,  A61K31/787 ,  A61K31/785 ,  A61K31/397 ,  A61K45/06

摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

公开(公告)号：US20170258825A1

公开(公告)日：2017-09-14

申请号：US15601291

申请日：2017-05-22

申请人： Relypsa, Inc.

发明人： Eric Connor ,  Kalpesh Biyani ,  Scott Hecker ,  Inez Lees ,  Paul Mansky ,  YongQi Mu ,  Faleh Salaymeh ,  Hongmin Zhang ,  David E. Bergbreiter ,  Grace Huynh ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao ,  Xinnan Zhang

IPC分类号： A61K31/785 ,  C08G73/02 ,  A61K45/06

CPC分类号： A61K31/785 ,  A61K45/06 ,  C08G73/02 ,  C08G73/0206 ,  A61K2300/00

摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

公开(公告)号：US10272103B2

公开(公告)日：2019-04-30

申请号：US14928517

申请日：2015-10-30

申请人： Relypsa, Inc.

发明人： Jordan Kopping ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Inez Lees ,  Grace May ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter

IPC分类号： A61K31/785 ,  C08F226/02 ,  A61K45/06 ,  C08F222/38 ,  C08F20/52 ,  C08F22/38 ,  C08F232/08

摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

公开(公告)号：US20160051576A1

公开(公告)日：2016-02-25

申请号：US14928517

申请日：2015-10-30

申请人： Relypsa, Inc.

发明人： Jordan Kopping ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Inez Lees ,  Grace Huynh ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao

IPC分类号： A61K31/785 ,  C08F226/02 ,  A61K45/06 ,  C08F222/38

CPC分类号： A61K31/785 ,  A61K45/06 ,  C08F20/52 ,  C08F22/385 ,  C08F222/385 ,  C08F226/02 ,  C08F232/08

摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.