公开(公告)号：US20190169342A1

公开(公告)日：2019-06-06

申请号：US16271296

申请日：2019-02-08

申请人： Relypsa, Inc.

发明人： Inez Lees ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Hongmin Zhang ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao ,  Xinnan Zhang

IPC分类号： C08F226/06 ,  C08G73/06 ,  C08G73/02 ,  A61K31/155 ,  A61K31/787 ,  A61K31/785 ,  A61K31/397 ,  A61K45/06

摘要： The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

公开(公告)号：US20170008980A1

公开(公告)日：2017-01-12

申请号：US15276175

申请日：2016-09-26

申请人： Relypsa, Inc.

发明人： Eric Connor ,  Faleh Salaymeh

IPC分类号： C08F8/12

CPC分类号： C08F8/12 ,  C08F20/12 ,  C08F22/10 ,  C08F120/22 ,  C08F220/22

摘要： The present invention generally relates to processes for converting an ester group to an acid group for polymers having a pendant ester of an acid group. This process is generally performed using an aqueous strong base.

摘要翻译： 本发明一般涉及将具有酸基侧基的聚合物的酯基转化成酸基的方法。 该方法通常使用水性强碱进行。

公开(公告)号：US10272103B2

公开(公告)日：2019-04-30

申请号：US14928517

申请日：2015-10-30

申请人： Relypsa, Inc.

发明人： Jordan Kopping ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Inez Lees ,  Grace May ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter

IPC分类号： A61K31/785 ,  C08F226/02 ,  A61K45/06 ,  C08F222/38 ,  C08F20/52 ,  C08F22/38 ,  C08F232/08

摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

公开(公告)号：US20180273653A1

公开(公告)日：2018-09-27

申请号：US15910630

申请日：2018-03-02

申请人： Relypsa, Inc.

发明人： Eric Connor ,  Faleh Salaymeh

IPC分类号： C08F8/12 ,  C08F120/22 ,  C08F22/10 ,  C08F20/12 ,  C08F220/22

CPC分类号： C08F8/12 ,  C08F20/12 ,  C08F22/10 ,  C08F120/22 ,  C08F220/22

摘要： The present invention generally relates to processes for converting an ester group to an acid group for polymers having a pendant ester of an acid group. This process is generally performed using an aqueous strong base.

公开(公告)号：US10058567B2

公开(公告)日：2018-08-28

申请号：US15069607

申请日：2016-03-14

申请人： Relypsa, Inc.

发明人： Michael J. Cope ,  Paul Mansky ,  Futian Liu ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Kalpesh Biyani ,  Mingjun Liu ,  Tony Kwok-Kong Mong ,  Yan Chen ,  Gerrit Klaerner ,  Jerry Buysse

IPC分类号： A61K31/795 ,  A61K9/14 ,  A61K9/50 ,  A61K31/75 ,  A61K31/785 ,  A61K31/74 ,  A61K33/06 ,  A61K9/00 ,  A61K9/16

CPC分类号： A61K31/795 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/1694 ,  A61K9/5026 ,  A61K31/74 ,  A61K31/75 ,  A61K31/785 ,  A61K33/06

摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

公开(公告)号：US20160193247A1

公开(公告)日：2016-07-07

申请号：US15069607

申请日：2016-03-14

申请人： Relypsa, Inc.

发明人： Michael J. Cope ,  Paul Mansky ,  Futian Liu ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Kalpesh Biyani ,  Mingjun Liu ,  Tony Kwok-Kong Mong ,  Yan Chen ,  Gerrit Klaerner ,  Jerry Buysse

IPC分类号： A61K31/795 ,  A61K9/50 ,  A61K9/00 ,  A61K31/785

CPC分类号： A61K31/795 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/1694 ,  A61K9/5026 ,  A61K31/74 ,  A61K31/75 ,  A61K31/785 ,  A61K33/06

摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

公开(公告)号：US20160051576A1

公开(公告)日：2016-02-25

申请号：US14928517

申请日：2015-10-30

申请人： Relypsa, Inc.

发明人： Jordan Kopping ,  Kalpesh Biyani ,  Eric Connor ,  Scott Hecker ,  Inez Lees ,  Grace Huynh ,  Faleh Salaymeh ,  Hongmin Zhang ,  David Bergbreiter ,  Paul Mansky ,  YongQi Mu ,  Michael James Cope ,  Elizabeth Goka ,  Angela Lee ,  Deidre Madsen ,  Jun Shao

IPC分类号： A61K31/785 ,  C08F226/02 ,  A61K45/06 ,  C08F222/38

CPC分类号： A61K31/785 ,  A61K45/06 ,  C08F20/52 ,  C08F22/385 ,  C08F222/385 ,  C08F226/02 ,  C08F232/08

摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.

公开(公告)号：US20140044804A1

公开(公告)日：2014-02-13

申请号：US14053725

申请日：2013-10-15

申请人： Relypsa, Inc.

发明人： Michael J. Cope ,  Paul Mansky ,  Futian Liu ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Kalpesh Biyani ,  Mingjun Liu ,  Tony Kwok-Kong Mong ,  Yan Chen

IPC分类号： A61K33/06

CPC分类号： A61K31/795 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/1694 ,  A61K9/5026 ,  A61K31/74 ,  A61K31/75 ,  A61K31/785 ,  A61K33/06

摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

摘要翻译： 本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。 特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。 还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。 本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。

公开(公告)号：US20180133244A1

公开(公告)日：2018-05-17

申请号：US15869930

申请日：2018-01-12

申请人： Relypsa, Inc.

发明人： Michael J. Cope ,  Paul Mansky ,  Futian Liu ,  Han-Ting Chang ,  Dominique Charmot ,  Eric Connor ,  Kalpesh Biyani ,  Mingjun Liu ,  Tony Kwok-Kong Mong ,  Yan Chen

IPC分类号： A61K31/795 ,  A61K33/06 ,  A61K31/785 ,  A61K31/75 ,  A61K9/00 ,  A61K9/50 ,  A61K31/74 ,  A61K9/16

CPC分类号： A61K31/795 ,  A61K9/0053 ,  A61K9/14 ,  A61K9/1694 ,  A61K9/5026 ,  A61K31/74 ,  A61K31/75 ,  A61K31/785 ,  A61K33/06

摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.

公开(公告)号：US20180125881A1

公开(公告)日：2018-05-10

申请号：US15865409

申请日：2018-01-09

申请人： Relypsa, Inc.

发明人： Detlef Albrecht ,  Michael Burdick ,  Han-Ting Chang ,  Dominique Charmot ,  Ramakrishnan Chidambaram ,  Eric Connor ,  Sherin Halfon ,  I-Zu Huang ,  Mingjun Liu ,  Jonathan Mills ,  Werner Strüver

IPC分类号： A61K31/78 ,  A61K31/7004 ,  C08K5/053

CPC分类号： A61K31/78 ,  A61K31/7004 ,  C08K5/053 ,  A61K2300/00

摘要： The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.