公开(公告)号：US20230383241A1

公开(公告)日：2023-11-30

申请号：US18200112

申请日：2023-05-22

Applicant: Repligen Corporation

Inventor： Charles Hill ,  Joey Tse ,  Mario Sinani ,  Earl Pineda

IPC: C12M1/00

CPC classification number: C12M47/10 ,  C12M29/10

Abstract: A bleed recovery system for use in a bioreactor system is disclosed. The bleed recovery system being configured to recover product of interest from the bleed material of the bioreactor system. In one embodiment, the bioreactor system includes a bleed recovery system for removing cell cultures from the bioreactor. The bleed recovery system includes a bleed pump coupled to the bioreactor so that cell bleed material can be removed from the bioreactor, a bleed vessel for receiving the cell bleed material, a cell retention device coupled to the bleed vessel, a harvest pump coupled to the cell retention device to deposit the product of interest into a second harvest tank, and a bleed pump connected to the bleed vessel to deposit the spent bleed material into a waste tank. Thus arranged, some or all of the product of interest can be separated from the spent medium.