公开(公告)号：US20230398112A1

公开(公告)日：2023-12-14

申请号：US18020687

申请日：2021-07-30

Applicant: Research Triangle Institute

Inventor： Ian Edward Stewart ,  Ignacio Luz Minguez ,  Anthony James Hickey

IPC: A61K31/4965 ,  A61K9/16 ,  A61K9/00 ,  A61K49/18 ,  A61K49/04

CPC classification number: A61K31/4965 ,  A61K9/1611 ,  A61K9/0073 ,  A61K49/1887 ,  A61K49/0419

Abstract: Spray-dried metal-organic frameworks (MOFs) comprising therapeutic and/or diagnostic metal ions and therapeutic and/or diagnostic organic ligands are described. Both the metal ion and organic ligand can have activity related to the treatment and/or diagnosis of a pulmonary disease or disorder, such as tuberculosis, or another disease related to a pulmonary infection. The MOFs can be adminstered to subjects via inhalation (e.g., as aerosols). Methods of treating and diagnosing pulmonary diseases or disorders are also described.