公开(公告)号：US11648202B2

公开(公告)日：2023-05-16

申请号：US16650965

申请日：2018-10-11

Applicant: Research Triangle Institute

Inventor： Elliott Richard Pauli ,  Hemant N. Joshi ,  Anvit S. Vasavada

IPC: A61K9/16 ,  A61K9/48 ,  A61K31/4706

CPC classification number: A61K9/1652 ,  A61K9/1658 ,  A61K9/4816 ,  A61K9/4866 ,  A61K31/4706

Abstract: Water-dispersible pharmaceutical compositions of hydroxychloroquine sulfate in powder or granule form are provided that allow for ease of preparation of measured-dose, liquid suspensions that are palatable and suitable for pediatric administration. The compositions in granular or powder form are efficiently dissolvable in water and can be provided encapsulated within a two-piece releasable hard capsule or a packet or pouch for easy release. An ion-pairing agent is present in the formulation of the composition that masks the bitter taste of the hydroxychloroquine sulfate, significantly reducing the need for addition of a sweetening agent. Methods are provided for preparing the water-dispersible pharmaceutical compositions of hydroxychloroquine sulfate and for preparing palatable weight-based pediatric doses.