公开(公告)号：US09827217B2

公开(公告)日：2017-11-28

申请号：US15281329

申请日：2016-09-30

申请人： Rgenix, Inc.

发明人： Eduardo J. Martinez ,  Andreas G. Grill ,  Aniruddh Singh ,  Padmini Kavuru

IPC分类号： A61K31/197 ,  A61K9/00 ,  A61K47/12

CPC分类号： A61K31/197 ,  A61K9/0019 ,  A61K47/12 ,  C07C57/15 ,  C07C279/14

摘要： The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof.

公开(公告)号：US10512623B2

公开(公告)日：2019-12-24

申请号：US15795540

申请日：2017-10-27

申请人： Rgenix, Inc.

发明人： Eduardo J. Martinez ,  Andreas G. Grill ,  Aniruddh Singh ,  Padmini Kavuru

IPC分类号： A61K31/197 ,  A61K47/14 ,  A61K47/12 ,  C07C279/14 ,  C07C57/15 ,  A61K9/00

摘要： The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof.

公开(公告)号：US09884813B1

公开(公告)日：2018-02-06

申请号：US15449428

申请日：2017-03-03

申请人： Rgenix, Inc.

发明人： Eduardo J. Martinez ,  Andreas G. Grill ,  Aniruddh Singh ,  Padmini Kavuru ,  Nicholas D. Paschalides ,  Stephen A. Wald

IPC分类号： A61K31/4439 ,  C07C279/14 ,  C07C57/15 ,  A61K9/00 ,  A61K31/155 ,  A61K31/194

CPC分类号： C07C279/14 ,  A61K9/0019 ,  A61K31/155 ,  A61K31/194 ,  C07B2200/13 ,  C07C57/15

摘要： The present invention relates to new pharmaceutical salts of β-GPA which exhibit improved physical properties. In particular, the invention relates to salts of β-GPA with improved flow properties (e.g., improved Carr's index and/or Hausner ratio) such as fumarate salts, succinate salts, and oxalate salts. The invention also relates to pharmaceutical compositions including a pharmaceutically effective amount of one or more salts of β-GPA, as well as methods of treating cancer including administration of a formulation including a β-GPA salt of the invention to a subject in need thereof.