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公开(公告)号：US4803216A
公开(公告)日：1989-02-07
申请号：US46656
申请日：1987-05-05
IPC分类号： A61K31/415 , C07D231/38
CPC分类号： C07D231/38
摘要： There are described compounds of formula I, ##STR1## in which R.sub.1 represents hydrogen, alkyl, alkanoyl or alkyl substituted by Ar.sub.1,R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, each independently represent hydrogen, alkyl or Ar.sub.3,Ar.sub.1, Ar.sub.2 and Ar.sub.3, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of alkyl, hydroxy, alkoxy, NR.sub.6 R.sub.7 or halogen,R.sub.6 and R.sub.7, which may be the same or different, independently represent hydrogen or alkyl,and pharmaceutically acceptable acid addition salts thereof.Compositions containing the compounds and methods for their preparation are also described.The compounds are indicated for use as pharmaceutical, e.g. anti-inflammatory, agents.
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公开(公告)号：US4810719A
公开(公告)日：1989-03-07
申请号：US733591
申请日：1985-05-10
IPC分类号： A61K31/415 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/47 , A61K31/505 , A61P29/00 , C07D213/57 , C07D231/06 , C07D231/38 , C07D333/00 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/00 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/12
CPC分类号： C07D231/06 , C07C255/00 , C07D213/57 , C07D231/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/12
摘要： There are described compounds of formula I, ##STR1## in which either R.sub.2 represents hydrogen, alkyl or Ar.sub.2, andR.sub.3 represents hydrogen, alkyl or alkyl substituted by Ar.sub.3 ;or R.sub.2 and R.sub.3 together form the chain --(CH.sub.2).sub.m --;R.sub.4 and R.sub.5, which may be the same or different, each independently represent hydrogen, halogen, Ar, alkyl, or alkyl substituted by Ar,Ar.sub.1, Ar.sub.2 and Ar, which may be the same or different each independently represent aryl or aryl substituted by one or more ofhalogen, hydroxy, --CN, --COR.sub.6, trihalomethyl, alkoxy, alkoxy substituted by --COR.sub.6, alkoxy substituted by --NR.sub.7 R.sub.8, alkyl, alkyl substituted by --COR.sub.6, alkyl substituted by NR.sub.7 R.sub.8, alkoxy substituted by Ar.sub.3, S(O).sub.n R.sub.9, --NR.sub.7 R.sub.8 or OAr.sub.3 ;R.sub.6 represents --OR.sub.10, --NR.sub.7 R.sub.8, hydrogen or alkyl;R.sub.7 and R.sub.8, which may be the same or different, each independently represent hydrogen, alkyl, alkanoyl or Ar.sub.3 ;R.sub.9 represents alkyl or Ar.sub.3 ;R.sub.10 represents hydrogen, alkyl or Ar.sub.3 ;m represents an integer from 3 to 6 inclusive;n represents 0, 1 or 2; andAr.sub.3 represents unsubstituted aryl;or a pharmaceutically acceptable derivative thereof.There are also described compositions containing the compounds and methods for their preparation.The compounds are indicated for use as pharmaceutical, e.g. anti-inflammatory, agents.
摘要翻译： 描述式I化合物，其中R 2表示氢，烷基或Ar 2，R 3表示氢，被Ar 3取代的烷基或烷基; 或R 2和R 3一起形成链 - （CH 2）m - ; R 4和R 5可以相同或不同，各自独立地表示氢，卤素，Ar，烷基或被Ar，Ar1，Ar2和Ar取代的烷基，它们可以相同或不同，各自独立地表示被 一个或多个卤素，羟基，-CN，-COR 6，三卤代甲基，烷氧基，被-COR 6取代的烷氧基，被-NR 7 R 8取代的烷氧基，被-COR 6取代的烷基，被NR 7 R 8取代的烷基，被Ar 3取代的烷氧基，S（ O）n R 9，-NR 7 R 8或OAr 3; R6表示-OR10，-NR7R8，氢或烷基; R 7和R 8可以相同或不同，各自独立地表示氢，烷基，烷酰基或Ar 3; R9代表烷基或Ar3; R 10表示氢，烷基或Ar 3; m表示3〜6的整数， n表示0,1或2; 和Ar 3表示未取代的芳基; 或其药学上可接受的衍生物。 还描述了含有这些化合物的组合物及其制备方法。 化合物指示用作药物，例如， 抗炎，药剂。
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公开(公告)号：US4824859A
公开(公告)日：1989-04-25
申请号：US606867
申请日：1984-05-03
IPC分类号： C07D231/06 , C07D401/04 , C07D401/12 , A61K31/415
CPC分类号： C07D231/06 , C07D401/04 , C07D401/12
摘要： There are described compounds of formula I, ##STR1## in which Ar.sub.1 and Ar.sub.2, which may be the same or different, each independently represent phenyl or pyridinyl, the phenyl or the pyridinyl each optionally being substituted by one or more of halogen; hydroxy; --COOR.sub.12 ; trihalomethyl; alkoxy C1 to 6; alkyl C1 to 6; --NR.sub.1 R.sub.2 ; alkoxy C1 to 6 substituted by --NR.sub.1 R.sub.2 or by phenyl; or alkyl C1 to 6 substituted by --NR.sub.1 R.sub.2 or by --COOR.sub.12 ;R.sub.1 and R.sub.2, which may be the same or different, each independently represent hydrogen or alkyl C1 to 6,R.sub.3 represents hydrogen, alkyl C1 to 6, alkanoyl C1 to 6, benzoyl, --COOR.sub.8, or --CONHR.sub.11,R.sub.4, R.sub.5, R.sub.6 and R.sub.7, which may be the same or different each independently represent hydrogen, alkyl C1 to 6 or phenyl,R.sub.8 represents alkyl C1 to 6 or aryl,R.sub.11 represents alkyl C1 to 6 or aryl,R.sub.12 represents hydrogen or alkyl C1 to 6, and pharmaceutically acceptable derivatives thereof.There are also described compositions containing the compounds and methods for their preparation.The compounds are indicated for use as pharmaceutical, eg antiinflammatory agents.
摘要翻译： 描述了式I的化合物，其中Ar 1和Ar 2可以相同或不同，各自独立地表示苯基或吡啶基，苯基或吡啶基各自任选被一个或多个卤素取代; 羟基; -COOR12; 三卤甲基 烷氧基C1至6; 烷基C1至6; -NR1R2; 被-NR 1 R 2取代的C 1-6烷氧基或苯基取代; 或被-NR 1 R 2或-COOR 12取代的C 1-6的烷基; R1和R2可以相同或不同，各自独立地表示氢或C1至6的烷基，R3表示氢，C1至6的烷基，C1至6的烷酰基，苯甲酰基，-COOR8或-CONHR11，R4，R5，R6 和R 7可以相同或不同，各自独立地表示氢，烷基C1至6或苯基，R8表示烷基C1至6或芳基，R11表示烷基C1至6或芳基，R12表示氢或C1-6烷基，和 药学上可接受的衍生物 还描述了含有这些化合物的组合物及其制备方法。 化合物被指示用作药物，例如抗炎剂。
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公开(公告)号：US4956378A
公开(公告)日：1990-09-11
申请号：US286268
申请日：1989-02-10
IPC分类号： C07D231/06 , C07D401/04 , C07D401/12
CPC分类号： C07D231/06 , C07D401/04 , C07D401/12
摘要： There are described compounds of formula I, ##STR1## in which Ar.sub.1 and Ar.sub.2, which may be the same or different, each independently represent phenyl or pyridinyl, the phenyl or the pyridinyl each optionally being substituted by one or more of halogen; hydroxy; --COOR.sub.12 ; trihalomethyl; alkoxy C1 to 6; alkyl C1 to 6; --NR.sub.1 R.sub.2 ; alkoxy C1 to 6 substituted by --NR.sub.1 R.sub.2 or by phenyl; or alkyl C1 to 6 substituted by --NR.sub.1 R.sub.2 or by --COOR.sub.12 ;R.sub.1 and R.sub.2, which may be the same or different, each independently represent hydrogen or alkyl C1 to 6,R.sub.3 represents hydrogen, alkyl C1 to 6, alkanoyl C1 to 6, benzoyl, --COOR.sub.8, or --CONHR.sub.11,R.sub.4, R.sub.5, R.sub.6 and R.sub.7, which may be the same or different each independently represent hydrogen, alkyl C1 to 6 or phenyl;R.sub.8 represents alkyl C1 to 6 or aryl,R.sub.11 represents alkyl C1 to 6 or aryl,R.sub.12 represents hydrogen or alkyl C1 to 6, and pharmaceutically acceptable derivatives thereof.There are also described compositions containing the compounds and methods for their preparation. The compounds are indicated for use as pharmaceutical, e.g. antiinflammatory agents.
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