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公开(公告)号：US20070025954A1
公开(公告)日：2007-02-01
申请号：US11454142
申请日：2006-06-15
IPC分类号： A61K31/785 , C08G73/02
CPC分类号： C08G73/0627 , A61K31/74 , A61K31/785 , A61K31/787 , A61K31/80 , C08G61/12 , C08G73/00 , C08G73/0226
摘要： Disclosed are ionene polymers having antimicrobial activity. “Ionene polymers” as used in this invention are cationic polymers in which a substantial proportion of the atoms providing the positive charge are quaternized nitrogens located in the main polymeric chain or backbone of the polymer rather than in pendant groups. Also disclosed are antimicrobial compositions comprising ionene polymers and methods for treating microbial infections in mammals comprising the step of administering to a mammal, a therapeutically effective amount of at least one antimicrobial composition of the invention. Also disclosed are antimicrobial compositions comprising at least one ionene polymer and methods for preventing, inhibiting or eliminating the growth, dissemination, and/or the accumulation of microorganisms on a susceptible surface (including, but not limited to, the formation of biofilms on a susceptible surface) comprising the step of contacting such surface with a composition of the invention.
摘要翻译： 公开了具有抗微生物活性的紫罗烯聚合物。 本发明中使用的“紫罗烯聚合物”是阳离子聚合物，其中提供正电荷的大部分原子是位于聚合物的主要聚合物链或骨架中而不是侧基的季铵化氮。 还公开了包含紫罗烯聚合物和用于治疗哺乳动物微生物感染的方法的抗微生物组合物，其包括向哺乳动物施用治疗有效量的本发明的至少一种抗微生物组合物的步骤。 还公开了包含至少一种紫罗烯聚合物的抗微生物组合物和用于预防，抑制或消除微生物在易感表面上的生长，扩散和/或积累的方法（包括但不限于在易感的表面上形成生物膜 包括使这种表面与本发明的组合物接触的步骤。
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公开(公告)号：US20060002887A1
公开(公告)日：2006-01-05
申请号：US11131944
申请日：2005-05-18
IPC分类号： A61K31/765
CPC分类号： A61K31/765 , A01N43/40 , A01N47/44 , A01N57/22 , A61K31/785 , C08G61/12 , C08G73/00 , C08G73/02 , C08G73/0226 , C08G73/0627 , Y02A50/473 , Y02A50/481
摘要： Polymerized ionene compounds are known to be effective antimicrobial substances. It has recently been appreciated that the molecular weight can affect the safety and efficacy of ionene compounds. In particular, it has been found that low molecular weight ionene oligomers (less than 50 repeat units) are less toxic than larger polymers with identical compositions. The invention discloses a plurality of ionene oligomers.
摘要翻译： 已知聚合的紫罗烯化合物是有效的抗微生物物质。 最近已经意识到分子量可以影响紫罗烯化合物的安全性和有效性。 特别地，已经发现低分子量的紫罗烯低聚物（小于50个重复单元）的毒性大于具有相同组成的较大的聚合物。 本发明公开了多种紫罗烯低聚物。
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3.发明申请公开(公告)号：US20060002888A1
公开(公告)日：2006-01-05
申请号：US11132150
申请日：2005-05-18
IPC分类号： A61K31/785
CPC分类号： A61K31/787 , A61K31/785 , A61K31/80 , Y02A50/473
摘要： A method of using ionene polymers for the treatment or prevention of infections (e.g., pulmonary infections) in cystic fibrosis patients is provided. The method comprises administering to a mammal an effective amount of an ionene polymer to prophylactically or therapeutically treat infections associated with cystic fibrosis.
摘要翻译： 提供了一种使用紫罗烯聚合物治疗或预防囊性纤维化患者感染（如肺部感染）的方法。 该方法包括向哺乳动物施用有效量的紫罗烯聚合物以预防或治疗地治疗与囊性纤维化相关的感染。
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