公开(公告)号：US20050013845A1

公开(公告)日：2005-01-20

申请号：US10706603

申请日：2003-11-12

申请人： Stephen Warren ,  David Osborne ,  Richard Holl

发明人： Stephen Warren ,  David Osborne ,  Richard Holl

IPC分类号： A61K9/00 ,  A61K9/70 ,  A61F6/06

CPC分类号： A61K9/0051 ,  A61K9/7023

摘要： The present invention provides bioerodible, water-soluble pharmaceutical carriers for ocular (e.g., transconjunctival or transcorneal) delivery of pharmaceuticals for either systemic or local therapy.

摘要翻译： 本发明提供用于全身或局部治疗的药物的用于眼部（例如，结膜结肠或转角膜）递送的生物可腐蚀的水溶性药物载体。

公开(公告)号：US08573039B2

公开(公告)日：2013-11-05

申请号：US12896267

申请日：2010-10-01

申请人： Richard Holl

发明人： Richard Holl

IPC分类号： G01M15/02

CPC分类号： G01M15/02

摘要： A compression tester adapter is provided. The compression adaptor includes a generally cylindrical plug fitting, including a pilot segment, an external thread, a cylinder segment, a gasket located between the external thread and the cylinder segment and a plug end; and a connector fitting including an attachment interface; and a hose attached to the plug fitting. A method of adapting a compression tester spark plug hose for use with a spark plug socket is provided. The method includes; engaging a threaded spark plug socket in an internal combustion engine cylinder head; attaching a compression tester spark plug hose; and transmitting a compressed gas to the compression tester spark plug hose wherein the spark plug socket thread is configured with a nominal diameter of 12 millimeters; and creating a substantially airtight seal against a periphery of a tapered seat near a inner extreme of the spark plug socket.

摘要翻译： 提供压缩测试仪适配器。 压缩适配器包括大致圆柱形的插头配件，包括导向段，外螺纹，气缸段，位于外螺纹和气缸段之间的垫圈和塞端; 以及连接器配件，其包括附接接口; 以及连接到插头配件的软管。 提供了一种使用压缩测试仪的火花塞软管与火花塞插座一起使用的方法。 该方法包括： 在内燃机气缸盖中接合带螺纹的火花塞插座; 安装压力测试仪火花塞软管; 以及将压缩气体传送到所述压缩试验器火花塞软管，其中所述火花塞插座螺纹构造为公称直径为12毫米; 并且在靠近火花塞插座的内部极端的锥形座的周边处产生基本上气密的密封。

公开(公告)号：US20080268021A1

公开(公告)日：2008-10-30

申请号：US12215101

申请日：2008-06-24

申请人： Stephen L. Warren ,  David W. Osborne ,  Richard Holl

发明人： Stephen L. Warren ,  David W. Osborne ,  Richard Holl

IPC分类号： A61K9/70 ,  A61K31/403 ,  A61K31/4523

CPC分类号： A61K9/0051 ,  A61K9/7023

摘要： The present invention provides bioerodible, water-soluble pharmaceutical carriers for ocular (e.g., transconjunctival or transcorneal) delivery of pharmaceuticals for either systemic or local therapy.

摘要翻译： 本发明提供用于全身或局部治疗的药物的用于眼部（例如，结膜结肠或转角膜）递送的生物可腐蚀的水溶性药物载体。

公开(公告)号：US20060286015A1

公开(公告)日：2006-12-21

申请号：US10570180

申请日：2004-09-04

申请人： Richard Holl

发明人： Richard Holl

IPC分类号： B01J19/00

CPC分类号： B01F7/008 ,  B01F5/221 ,  B01F7/00758 ,  B01F7/00783 ,  B01F7/00791 ,  B01F7/00825 ,  B01F7/00833 ,  B01F2215/0427 ,  B01J10/02 ,  B01J14/00 ,  B01J19/1887 ,  B01J2219/00085

摘要： New methods of operating surface reactors, and such reactors, particularly spinning disk reactors, require that a first reactant is fed to a reactor surface (20) and forms a thin radially outward moving film (60) thereon in a reaction passage (42) formed between the reaction surface (20) and a parallel, closely spaced (less than 1 mm) retaining surface (40). The passage thickness is precisely controllable and the surfaces (20, 40) move relative to one another so that strong shear is applied to the material between them. A second reactant is fed to the surface (20) as a second thin film (65) that as it enters the first film (60), preferably perpendicularly, it is immediately merged therewith along a correspondingly very narrow interaction line (66) by the shear at a rate such as to break up molecular clusters in the films, so that their molecules can aggressively and completely interact by forced interdiffusion. In spinning disk (18) apparatus the first film (60) is fed along the spin axis (14), while subsequent films (65, etc.) are fed at respective distances from the axis (14) such that there is adequate shear for the molecular cluster disruption. Preferably each film (65, etc.) after the first (60) is fed into the reaction passage (42) through a respective thin annular nozzle producing a thin circular film (65) that simultaneously merges with the first film (60) along its entire length.

摘要翻译： 操作表面反应器和这种反应器，特别是旋转盘式反应器的新方法要求将第一反应物供入反应器表面（20），并在其上形成薄的径向向外的移动膜（60），形成在反应通道（42）中 在反应表面（20）和平行紧密间隔（小于1mm）的保持表面（40）之间。 通道厚度是精确可控的，并且表面（20,40）相对于彼此移动，使得强剪切被施加到它们之间的材料。 第二反应物作为第二薄膜（65）被馈送到表面（20），第二薄膜（65）当其进入第一薄膜（60）时，优选地垂直于其，沿相应的非常窄的相互作用线（66）立即与其合并 以一定的速率剪切，以破坏膜中的分子簇，使得它们的分子可以通过强制相互扩散而积极和完全地相互作用。 在旋转盘（18）装置中，第一膜（60）沿着旋转轴线（14）进给，而随后的膜（65等）以相对于轴线（14）的距离进给，使得存在足够的剪切 分子簇破坏。 优选地，第一（60）之后的每个膜（65等）通过相应的薄环形喷嘴供给到反应通道（42）中，产生薄的圆形膜（65），其同时与第一膜（60）沿其 全长。

公开(公告)号：US20060243038A1

公开(公告)日：2006-11-02

申请号：US11116285

申请日：2005-04-28

申请人： Joe Young ,  Richard Holl

发明人： Joe Young ,  Richard Holl

IPC分类号： G01M15/00

CPC分类号： G01M15/08

摘要： A compression tester adapter includes a plug fitting, a connector fitting and a flexible hose connected to the plug fitting and to the connector fitting to adapt a standard internal combustion engine cylinder compression tester hose assembly to a 16-millimeter threaded spark plug socket in an internal combustion engine cylinder head.

摘要翻译： 压缩测试器适配器包括插头配件，连接器配件和连接到插头配件和连接器配件的柔性软管，以将标准内燃机气缸压缩测试器软管组件适配成内部的16毫米螺纹火花塞插座 内燃机气缸盖。

公开(公告)号：US08889174B1

公开(公告)日：2014-11-18

申请号：US13589847

申请日：2012-08-20

申请人： John W. Gibson ,  Arthur J. Tipton ,  Richard Holl ,  Stacey Meador

发明人： John W. Gibson ,  Arthur J. Tipton ,  Richard Holl ,  Stacey Meador

IPC分类号： A61F2/00 ,  A61K9/00

CPC分类号： A61K9/0002 ,  A61F2/02 ,  A61F2250/0067 ,  A61K9/0024

摘要： A coaxial implant has been developed using biodegradable polymeric materials. The coaxial implant has a core containing drug, surrounded by a semi-permeable membrane that controls the rate of release of material from the core. The core containing the drug and the polymer membrane(s) can be the same or different polymer. The core acts as a reservoir of drug, which partitions from the core polymer to form a saturated solution of drug at the polymer membrane.

摘要翻译： 已经开发出使用可生物降解的聚合材料的同轴植入物。 同轴植入物具有包含核心的药物，被半透膜围绕，该半透膜控制材料从核心释放的速度。 含有药物和聚合物膜的核心可以是相同或不同的聚合物。 核心作为药物储存器，其与核心聚合物分隔开，以在聚合物膜上形成饱和的药物溶液。

公开(公告)号：US20070207192A1

公开(公告)日：2007-09-06

申请号：US11645091

申请日：2006-12-22

申请人： Richard Holl ,  David Osborne

发明人： Richard Holl ,  David Osborne

IPC分类号： A61K9/70 ,  A61K36/254 ,  A61K36/84 ,  A61K36/539 ,  A61K36/16 ,  A61K36/8962 ,  A61K36/81 ,  A61K36/28 ,  A61K36/258

CPC分类号： A61K9/006 ,  A61K9/7007

摘要： The present invention is directed to a mucoadhesive delivery system for the local or systemic administration of a pharmaceutical agent. The delivery system of the invention effectively and facilely enables transport of the pharmaceutical agent through mucosal membranes and into the vasculattire of the mucosa. The delivery system includes an at least partially water soluble bioadhesive layer and an at least partially water soluble backing layer. Incorporated within either or both of these layers are the pharmaceutical agent and a mucosal penetration enhancing agent. The mucosal penetration enhancing agent displays localized tissue irritation properties. The mucoadhesive delivery system may be in the form of a gel, film, disc or patch. It may be applied to any mucosal membrane of a patient including but not limited to those of the buccal and nasal cavities, throat, eye, vagina, alimentary tract and peritoneum.

摘要翻译： 本发明涉及用于局部或全身施用药剂的粘膜粘附递送系统。 本发明的递送系统有效且便利地使得药剂通过粘膜和粘膜的血管连接物的运输。 递送系统包括至少部分水溶性生物粘附层和至少部分水溶性背衬层。 这些层中的任一个或两者中的药物是粘剂渗透促进剂。 粘膜渗透增强剂显示局部组织刺激性质。 粘膜粘附递送系统可以是凝胶，膜，盘或贴剂的形式。 它可以应用于患者的任何粘膜，包括但不限于颊腔和鼻腔，咽喉，眼睛，阴道，消化道和腹膜的那些。

公开(公告)号：US20060245991A1

公开(公告)日：2006-11-02

申请号：US11457435

申请日：2006-07-13

申请人： Richard Holl ,  Eric Gulliver ,  James Doss

发明人： Richard Holl ,  Eric Gulliver ,  James Doss

IPC分类号： B01J8/04 ,  B01J10/00

CPC分类号： B01F7/008 ,  B01F15/065 ,  B01J19/0093 ,  B01J19/1887 ,  B01J2219/00096 ,  B01J2219/00788 ,  B01J2219/00835 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00889 ,  C07C51/09 ,  C07C51/265 ,  C07C63/26 ,  C07C63/04

摘要： The present disclosure provides processes and apparatus for the production of materials requiring a plurality of chemical reaction steps. In the prior art the number of reaction vessels is minimized by performing two or more reactions together in the same vessel. Instead each process is separated into separate successive steps, in each of which at least two principal components are reacted together, with or without at least one catalyst. In each step the components are reacted under optimum condition for that reaction, using motion-augmented, sub-Kolmogoroff, micro-agitation provided by a separate discrete motor-operated, micro-agitation means. Such means are much smaller in size, but are extremely flexible as to the flow rate and reaction conditions, so that they can be adjusted to suit the reaction, without compromises dictated by attempting to perform other reactions in the same vessel. Multiple micro-agitation means in parallel or in series can be used in each step to increase capacity without scale-up problems, and units can be serviced or capacity reduced without the need to close down the process. Motor-operated micro-agitation means performing a non-chemical action can be provided at any stage of the process. Between each two steps the resultant mixture is separated to give a principal component used in the subsequent step, while at least one new principal component is added in the next step.

摘要翻译： 本公开提供了用于生产需要多个化学反应步骤的材料的方法和装置。 在现有技术中，通过在同一容器中一起进行两次或更多次反应来使反应容器的数量最小化。 相反，每个过程被分离成单独的连续步骤，其中每个过程中至少两个主要组分一起反应，具有或不具有至少一种催化剂。 在每个步骤中，组分在该反应的最佳条件下反应，使用运动增强的次Kolmogoroff，通过单独的分立的电动操作的微搅拌装置提供的微搅拌。 这种方式的尺寸要小得多，但是对于流速和反应条件来说是非常灵活的，因此可以调整它们以适应反应，而不受试图在同一容器中进行其它反应所规定的折中。 可以在每个步骤中使用并联或串联的多个微搅拌装置，以增加容量而不会出现放大问题，并且可以在不需要关闭过程的情况下对单元进行维修或降低容量。 可以在该过程的任何阶段提供执行非化学作用的电动微搅拌装置。 在每两个步骤之间，分离所得混合物以产生在后续步骤中使用的主要组分，而在下一步骤中加入至少一种新的主​​要组分。

公开(公告)号：US20120079877A1

公开(公告)日：2012-04-05

申请号：US12896267

申请日：2010-10-01

申请人： Richard Holl

发明人： Richard Holl

IPC分类号： G01M15/02

CPC分类号： G01M15/02

摘要： A compression tester adapter is provided. The compression adaptor includes a generally cylindrical plug fitting, including a pilot segment, an external thread, a cylinder segment, a gasket located between the external thread and the cylinder segment and a plug end; and a connector fitting including an attachment interface; and a hose attached to the plug fitting. A method of adapting a compression tester spark plug hose for use with a spark plug socket is provided. The method includes; engaging a threaded spark plug socket in an internal combustion engine cylinder head; attaching a compression tester spark plug hose; and transmitting a compressed gas to the compression tester spark plug hose wherein the spark plug socket thread is configured with a nominal diameter of 12 millimeters; and creating a substantially airtight seal against a periphery of a tapered seat near a inner extreme of the spark plug socket.

摘要翻译： 提供压缩测试仪适配器。 压缩适配器包括大致圆柱形的插头配件，包括导向段，外螺纹，气缸段，位于外螺纹和气缸段之间的垫圈和塞端; 以及连接器配件，其包括附接接口; 以及连接到插头配件的软管。 提供了一种使用压缩测试仪的火花塞软管与火花塞插座一起使用的方法。 该方法包括： 在内燃机气缸盖中接合带螺纹的火花塞插座; 安装压力测试仪火花塞软管; 以及将压缩气体传送到所述压缩试验器火花塞软管，其中所述火花塞插座螺纹构造为公称直径为12毫米; 并且在靠近火花塞插座的内部极端的锥形座的周边处产生基本上气密的密封。

公开(公告)号：US07216531B2

公开(公告)日：2007-05-15

申请号：US11116285

申请日：2005-04-28

申请人： Joe Young ,  Richard Holl

发明人： Joe Young ,  Richard Holl

IPC分类号： G01M15/00

CPC分类号： G01M15/08

摘要： A compression tester adapter includes a plug fitting, a connector fitting and a flexible hose connected to the plug fitting and to the connector fitting to adapt a standard internal combustion engine cylinder compression tester hose assembly to a 16-millimeter threaded spark plug socket in an internal combustion engine cylinder head.

摘要翻译： 压缩测试器适配器包括插头配件，连接器配件和连接到插头配件和连接器配件的柔性软管，以将标准内燃机气缸压缩测试器软管组件适配成内部的16毫米螺纹火花塞插座 内燃机气缸盖。