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    Adhesive bioerodible transmucosal drug delivery system
    2.
    发明申请
    Adhesive bioerodible transmucosal drug delivery system 审中-公开
    粘合剂生物可蚀性经粘膜药物输送系统

    公开(公告)号：US20070207192A1

    公开(公告)日：2007-09-06

    申请号：US11645091

    申请日：2006-12-22

    申请人： Richard Holl ,  David Osborne

    发明人： Richard Holl ,  David Osborne

    IPC分类号： A61K9/70 ,  A61K36/254 ,  A61K36/84 ,  A61K36/539 ,  A61K36/16 ,  A61K36/8962 ,  A61K36/81 ,  A61K36/28 ,  A61K36/258

    CPC分类号： A61K9/006 ,  A61K9/7007

    摘要： The present invention is directed to a mucoadhesive delivery system for the local or systemic administration of a pharmaceutical agent. The delivery system of the invention effectively and facilely enables transport of the pharmaceutical agent through mucosal membranes and into the vasculattire of the mucosa. The delivery system includes an at least partially water soluble bioadhesive layer and an at least partially water soluble backing layer. Incorporated within either or both of these layers are the pharmaceutical agent and a mucosal penetration enhancing agent. The mucosal penetration enhancing agent displays localized tissue irritation properties. The mucoadhesive delivery system may be in the form of a gel, film, disc or patch. It may be applied to any mucosal membrane of a patient including but not limited to those of the buccal and nasal cavities, throat, eye, vagina, alimentary tract and peritoneum.

    摘要翻译： 本发明涉及用于局部或全身施用药剂的粘膜粘附递送系统。 本发明的递送系统有效且便利地使得药剂通过粘膜和粘膜的血管连接物的运输。 递送系统包括至少部分水溶性生物粘附层和至少部分水溶性背衬层。 这些层中的任一个或两者中的药物是粘剂渗透促进剂。 粘膜渗透增强剂显示局部组织刺激性质。 粘膜粘附递送系统可以是凝胶，膜，盘或贴剂的形式。 它可以应用于患者的任何粘膜，包括但不限于颊腔和鼻腔，咽喉，眼睛，阴道，消化道和腹膜的那些。

    SHOE SOLE SANITIZING ASSEMBLY AND METHOD
    3.
    发明申请
    SHOE SOLE SANITIZING ASSEMBLY AND METHOD 有权

    公开(公告)号：US20210298563A1

    公开(公告)日：2021-09-30

    申请号：US16835572

    申请日：2020-03-31

    申请人： David Osborne

    发明人： David Osborne

    IPC分类号： A47L23/26

    摘要： A shoe sole sanitizing assembly includes a housing that has a bottom wall, a top wall and a perimeter wall. The top wall has an opening extending therethrough. A cylinder is rotatably mounted to the housing and extends through the opening. An outer surface of the cylinder is comprised of an adsorptive material. A sanitizing fluid is positioned within the housing and the adsorptive material is in contact with the fluid. The sanitizing fluid coats the cylinder and applies the sanitizing fluid to a bottom of a shoe sole when the shoe sole is moved across the cylinder while the cylinder rotates relative to the housing.

    Protectant for UV-induced skin damage
    5.
    发明申请
    Protectant for UV-induced skin damage 有权
    紫外线诱发皮肤损伤的保护剂

    公开(公告)号：US20050186156A1

    公开(公告)日：2005-08-25

    申请号：US11011291

    申请日：2004-12-14

    申请人： David Osborne

    发明人： David Osborne

    IPC分类号： A61K8/46 ,  A61K31/10 ,  A61K31/136 ,  A61Q17/04 ,  A61K7/42 ,  A61K31/12

    CPC分类号： A61K31/136 ,  A61K8/46 ,  A61Q17/04

    摘要： The present invention provides a method for protecting against UV radiation-induced skin damage. Specifically, compositions including dapsone are administered to provide UV protection. The dapsone compositions may be administered orally, or by other parenteral routes, such as topically, transdermally, by inhalation, and the like.

    摘要翻译： 本发明提供一种防止紫外线辐射诱导的皮肤损伤的方法。 具体地，施用包含氨苯砜的组合物以提供UV保护。 氨苯砜酮组合物可以口服给药或通过其它肠胃外途径给药，例如局部，透皮，吸入等。

    Zone demand controlled dual air conditioning system and controller therefor
    7.
    发明授权
    Zone demand controlled dual air conditioning system and controller therefor 有权
    区域需求控制双重空调系统及其控制器

    公开(公告)号：US06792766B2

    公开(公告)日：2004-09-21

    申请号：US10264645

    申请日：2002-10-04

    申请人： David Osborne ,  Brian Chester ,  Gary R. Scoggins

    发明人： David Osborne ,  Brian Chester ,  Gary R. Scoggins

    IPC分类号： F25B2900

    CPC分类号： F24F3/00 ,  F24F11/77 ,  F24F2221/54 ,  F25B39/02

    摘要： A thermal zone demand controlled air conditioning fan coil unit using dual cascade arranged heat pumps, chilled water, or a combination of chilled water and hot water, with or without back up electric resistance heat strips, and having an air circulation system for circulating air to and from a plurality of thermal zones and including a conditioned air chamber having first and second heat exchange refrigerant coils or direct or reversed cycle water coils being connected in refrigerant circulating relation respectively with the heat pumps, chilled water coil. A plurality of thermal zone blowers conduct conditioned air from the conditioned air chamber to respective thermal zones of a building space. Electronic controller circuitry of the system is coupled for thermal demand control of the heat pumps and the thermal zone blowers for operation of the first heat pump during average thermal load and for operation of both heat pumps during greater thermal load. For chilled or hot water systems, the controller controls operation of thermal zone blowers and motorized valves which control the flow of water to and from the water coils. The electronic controller circuitry further provides thermostat control circuitry having set point change capability at any of the thermal zone thermostats and periodically reverses heat pump operation to compensate for uneven wear.

    摘要翻译： 一个热区域需求控制的空调风机盘管单元，使用双级联排列的热泵，冷冻水或冷冻水和热水的组合，有或没有备用电阻热带，并具有用于循环空气的空气循环系统 并且包括具有第一和第二热交换制冷剂盘管的调节空气室或直接或反向循环水盘管，所述调节空气室与制冷剂循环关系分别与所述热泵，冷水盘管相连。 多个热区鼓风机将经调节的空气室的调节空气传送到建筑空间的各个热区。 该系统的电子控制器电路耦合用于热泵和热区鼓风机的热需求控制，用于在平均热负荷期间操作第一热泵并且在较大的热负载期间操作两个热泵。 对于冷冻或热水系统，控制器控制热区鼓风机和电动阀门的运行，从而控制往返于水盘管的水流量。 电子控制器电路还提供在任何热区恒温器处具有设定点变化能力的温控器控制电路，并周期性地反转热泵操作以补偿不均匀的磨损。

    Hinge
    8.
    发明授权
    Hinge 失效
    合页

    公开(公告)号：US4748717A

    公开(公告)日：1988-06-07

    申请号：US917963

    申请日：1986-10-14

    申请人： David Osborne

    发明人： David Osborne

    IPC分类号： E05D5/10 ,  E05D7/00 ,  E05D7/04 ,  E05D5/00 ,  E05D5/12

    CPC分类号： E05D7/0054 ,  E05D7/0027 ,  E05D2005/102 ,  E05D5/10 ,  E05Y2900/132 ,  E05Y2900/40 ,  Y10T16/53235 ,  Y10T16/53238 ,  Y10T16/53247 ,  Y10T16/53253 ,  Y10T16/541 ,  Y10T16/553 ,  Y10T16/554

    摘要： A hinge is disclosed which has a barrel 12 which is screw threaded at least at its ends. A grub screw 16 is inserted into one end of the barrel and can be screwed into and out of the barrel to adjust the relative height of a pin 22 inserted into the barrel to enable the height of a gate to be adjusted. The hinge can be used as a left or right hand hinge by simply inverting the hinge and screwing the grub screw 16 into the appropriate end of the hinge. An intermediate element 70 may be included to adjust for misalignment of the gates. The intermediate element has an eccentric bore 73 and the element can be rotated within the barrel 12 and locked to the pin 22 to adjust the pivot point of the pin 22 in the barrel 12 and thereby adjust for any misalignment of the hinge.

    摘要翻译： 公开了一种铰链，其具有至少在其端部具有螺纹的筒体12。 平头螺钉16插入筒体的一端，并且可以拧入和移出筒体，以调节插入筒体中的销钉22的相对高度，以使得门的高度得以调节。 铰链可以通过简单地翻转铰链并将平头螺钉16拧入铰链的适当端部而用作左手或右手铰链。 可以包括中间元件70以调整门的未对准。 中间元件具有偏心孔73，并且该元件可以在镜筒12内旋转并且锁定到销22上，以调节针筒12中销22的枢转点，从而调整铰链的任何未对准。

    Adherent Fabric Articles and Associated Methods
    9.
    发明申请
    Adherent Fabric Articles and Associated Methods 审中-公开
    粘附织物和相关方法

    公开(公告)号：US20100304099A1

    公开(公告)日：2010-12-02

    申请号：US12790643

    申请日：2010-05-28

    申请人： David Osborne ,  Darren Jones

    发明人： David Osborne ,  Darren Jones

    IPC分类号： B32B3/10 ,  B32B5/02

    CPC分类号： B32B27/12 ,  B32B5/022 ,  B32B5/024 ,  B32B5/08 ,  B32B5/22 ,  B32B5/26 ,  B32B7/12 ,  B32B27/08 ,  B32B27/30 ,  B32B27/36 ,  B32B2262/0261 ,  B32B2262/0276 ,  B32B2262/12 ,  B32B2270/00 ,  B32B2307/546 ,  B32B2432/00 ,  Y10T428/2481 ,  Y10T428/249921

    摘要： Adherent fabric articles and uses therefor are disclosed and described. In one aspect, an adherent fabric article may include a fabric layer bonded to a cling layer. In use, the fabric layer can be used to clean, polish, or treat a surface of a device, such as a scratch sensitive surface. Once cleaning, polishing, or treating is complete, the adherent fabric article can be stored on the device by adhering it to a smooth surface on the device using the cling layer. Moreover, in this position, the article may be used to protect the surface of the device to which the article is adhered. Further, the fabric portion of the article may be imaged to allow the article to be decorative in nature when adorning a device, or to provide messaging or advertisement.

    摘要翻译： 公开和描述粘附织物制品及其用途。 在一个方面，粘合织物制品可以包括结合到粘附层的织物层。 在使用中，织物层可用于清洁，抛光或处理装置的表面，例如耐刮擦表面。 一旦清洁，抛光或处理完成，粘附的织物制品可以通过使用粘附层将其粘附在装置上的光滑表面上而存储在装置上。 此外，在该位置，可以使用该物品来保护物品被粘附到的装置的表面。 此外，制品的织物部分可以被成像，以允许物品在装饰装置时是装饰性的，或者提供消息或广告。

    Emulsive composition containing Dapsone
    10.
    发明申请
    Emulsive composition containing Dapsone 审中-公开
    含有氨苯砜的乳化组合物

    公开(公告)号：US20060204526A1

    公开(公告)日：2006-09-14

    申请号：US11352935

    申请日：2006-02-13

    申请人： Robert Lathrop ,  David Osborne

    发明人： Robert Lathrop ,  David Osborne

    IPC分类号： A61K9/00 ,  A61K31/135

    CPC分类号： A61K31/135 ,  A61K9/0014 ,  A61K9/107 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34

    摘要： The present invention relates to a topical, emulsive composition containing Dapsone or its derivative. The inventive composition incorporates emollients and Dapsone or its derivative in a stable emulsion. The stability is achieved through the use of a combination of certain surfactant mixtures and an enhancer providing solubility of the Dapsone.

    摘要翻译： 本发明涉及含有氨苯砜或其衍生物的局部用乳化组合物。 本发明的组合物将柔软剂和氨苯砜或其衍生物掺入稳定的乳液中。 通过使用某些表面活性剂混合物和提供氨苯砜的溶解度的增强剂的组合来实现稳定性。