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公开(公告)号：US09144562B2
公开(公告)日：2015-09-29
申请号：US14102146
申请日：2013-12-10
IPC分类号： A61K9/107 , A61K9/00 , A61K31/231 , A61K31/22
CPC分类号： A61K31/231 , A61K9/0019 , A61K9/0053 , A61K9/107 , A61K31/22
摘要： The present invention relates to omega-3 diglyceride emulsions characterized in that the lipid phase comprises at least about 40 wt.-% of diglycerides. Preferably about 70 wt.-% of the acyl-groups of said diglycerides are eicoapentaenoic acid (EPA) groups and/or docasahexaenoic (DHA) groups. The invention further relates to methods of treatment using the omega-3 diglyceride emulsions.
摘要翻译： 本发明涉及ω-3二甘油酯乳剂，其特征在于脂质相包含至少约40重量％的甘油二酯。 优选地，所述甘油二酯的约70重量％的酰基是二十五碳烯酸（EPA）基团和/或二十二碳六烯酸（DHA）基团。 本发明还涉及使用ω-3甘油二酯乳剂的治疗方法。
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公开(公告)号：US20130315968A1
公开(公告)日：2013-11-28
申请号：US13953718
申请日：2013-07-29
IPC分类号： A61K31/231
CPC分类号： A61K31/231 , A61K9/0019 , A61K9/0053 , A61K9/107 , A61K31/22
摘要： The present invention relates to omega-3 diglyceride emulsions characterized in that the lipid phase comprises at least about 40 wt.-% of diglycerides. Preferably about 70 wt.-% of the acyl-groups of said diglycerides, are eicoapentaenoic acid (EPA) groups and/or docasahexaenoic (DHA) groups. The invention further relates to methods of treatment using the omega-3 diglyceride emulsions.
摘要翻译： 本发明涉及ω-3二甘油酯乳剂，其特征在于脂质相包含至少约40重量％的甘油二酯。 优选地，所述甘油二酯的约70重量％的酰基是2-五氟乙烯酸（EPA）基团和/或二十二碳六烯酸（DHA）基团。 本发明还涉及使用ω-3甘油二酯乳剂的治疗方法。
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公开(公告)号：US08633253B2
公开(公告)日：2014-01-21
申请号：US13953718
申请日：2013-07-29
IPC分类号： B01F3/00
CPC分类号： A61K31/231 , A61K9/0019 , A61K9/0053 , A61K9/107 , A61K31/22
摘要： The present invention relates to omega-3 diglyceride emulsions characterized in that the lipid phase comprises at least about 40 wt.-% of diglycerides. Preferably about 70 wt.-% of the acyl-groups of said diglycerides, are eicoapentaenoic acid (EPA) groups and/or docasahexaenoic (DHA) groups. The invention further relates to methods of treatment using the omega-3 diglyceride emulsions.
摘要翻译： 本发明涉及ω-3二甘油酯乳剂，其特征在于脂质相包含至少约40重量％的甘油二酯。 优选地，所述甘油二酯的约70重量％的酰基是2-五氟乙烯酸（EPA）基团和/或二十二碳六烯酸（DHA）基团。 本发明还涉及使用ω-3甘油二酯乳剂的治疗方法。
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公开(公告)号：US08536232B2
公开(公告)日：2013-09-17
申请号：US13783779
申请日：2013-03-04
IPC分类号： B01F3/00
CPC分类号： A61K31/231 , A61K9/0019 , A61K9/0053 , A61K9/107 , A61K31/22
摘要： The present invention relates to omega-3 diglyceride emulsions characterized in that the lipid phase comprises at least about 40 wt.-% of diglycerides. Preferably about 70 wt.-% of the acyl-groups of said diglycerides, are eicosapentaenoic acid (EPA) groups and/or docosahexaenoic (DHA) groups. The invention further relates to methods of treatment using the omega-3 diglyceride emulsions.
摘要翻译： 本发明涉及ω-3二甘油酯乳剂，其特征在于脂质相包含至少约40重量％的甘油二酯。 优选约70重量％的所述甘油二酯的酰基是二十碳五烯酸（EPA）基团和/或二十二碳六烯酸（DHA）基团。 本发明还涉及使用ω-3甘油二酯乳剂的治疗方法。
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公开(公告)号：US08410181B2
公开(公告)日：2013-04-02
申请号：US12441795
申请日：2007-09-19
IPC分类号： B01F3/00
CPC分类号： A61K31/231 , A61K9/0019 , A61K9/0053 , A61K9/107 , A61K31/22
摘要： The present invention relates to omega-3 diglyceride emulsions characterized in that the lipid phase comprises at least about 40 wt.-% of diglycerides. Preferably about 70 wt. -% of the acyl-groups of said diglycerides, are eicosapentaenoic acid (EPA) groups and/or docosahexaenoic (DHA) groups. The invention further relates to methods of treatment using the omega-3 diglyceride emulsions.
摘要翻译： 本发明涉及ω-3二甘油酯乳剂，其特征在于脂质相包含至少约40重量％的甘油二酯。 优选约70wt。 - 所述甘油二酯的酰基的百分比是二十碳五烯酸（EPA）基团和/或二十二碳六烯酸（DHA）基团。 本发明还涉及使用ω-3甘油二酯乳剂的治疗方法。
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公开(公告)号：US20140099345A1
公开(公告)日：2014-04-10
申请号：US14102146
申请日：2013-12-10
IPC分类号： A61K31/231
CPC分类号： A61K31/231 , A61K9/0019 , A61K9/0053 , A61K9/107 , A61K31/22
摘要： The present invention relates to omega-3 diglyceride emulsions characterized in that the lipid phase comprises at least about 40 wt.-% of diglycerides. Preferably about 70 wt.-% of the acyl-groups of said diglycerides are eicoapentaenoic acid (EPA) groups and/or docasahexaenoic (DHA) groups. The invention further relates to methods of treatment using the omega-3 diglyceride emulsions.
摘要翻译： 本发明涉及ω-3二甘油酯乳剂，其特征在于脂质相包含至少约40重量％的甘油二酯。 优选地，所述甘油二酯的约70重量％的酰基是二十五碳烯酸（EPA）基团和/或二十二碳六烯酸（DHA）基团。 本发明还涉及使用ω-3甘油二酯乳剂的治疗方法。
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公开(公告)号：US20100093856A1
公开(公告)日：2010-04-15
申请号：US12441795
申请日：2007-09-19
IPC分类号： A61K31/225 , A61P43/00
CPC分类号： A61K31/231 , A61K9/0019 , A61K9/0053 , A61K9/107 , A61K31/22
摘要： The present invention relates to omega-3 diglyceride emulsions characterized in that the lipid phase comprises at least about 40 wt.-% of diglycerides. Preferably about 70 wt. -% of the acyl-groups of said diglycerides, are eicosapentaenoic acid (EPA) groups and/or docosahexaenoic (DHA) groups. The invention further relates to methods of treatment using the omega-3 diglyceride emulsions.
摘要翻译： 本发明涉及ω-3二甘油酯乳剂，其特征在于脂质相包含至少约40重量％的甘油二酯。 优选约70wt。 - 所述甘油二酯的酰基的百分比是二十碳五烯酸（EPA）基团和/或二十二碳六烯酸（DHA）基团。 本发明还涉及使用ω-3甘油二酯乳剂的治疗方法。
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8.发明申请Use of an Omega-3 Lipid-Based Emulsion Following Ischemic Injury to Provide Protection and Recovery in Human Organs 审中-公开缺血性损伤后使用基于Omega-3的脂质乳剂，提供人体器官的保护和恢复公开(公告)号：US20150272921A1
公开(公告)日：2015-10-01
申请号：US14738822
申请日：2015-06-12
IPC分类号： A61K31/232 , A61K31/202 , A61K35/60 , A61K9/107
CPC分类号： A61K31/232 , A61K9/107 , A61K31/202 , A61K31/22 , A61K35/60
摘要： The present invention provides methods of limiting cell death resulting from hypoxic-ischemia comprising, administering an omega-3 lipid-based emulsion after a hypoxic-ischemia insult. The omega-3 lipid-based emulsion preferably comprises at least 20% omega-3 oil, by weight, and wherein the omega-3 oil comprises at least 20% omega-3 triglycerides and/or diglycerides, and wherein fatty acids of the omega-3 trigylceride and/or diglycerides comprise at least 40% EPA and/or DHA. The present invention also provides novel fish-oil compositions for administration after an ischemic insult to limit cell death in the organ that underwent an ischemic event.
摘要翻译： 本发明提供限制由缺氧缺血引起的细胞死亡的方法，包括在缺氧缺血损伤后施用基于ω-3脂质的乳剂。 基于ω-3脂质的乳液优选包含至少20重量％的ω-3油，其中ω-3油包含至少20％的ω-3甘油三酯和/或甘油二酯，并且其中ω- -3甘油三酯和/或甘油二酯包含至少40％的EPA和/或DHA。 本发明还提供了用于在缺血性损伤之后施用以限制经历缺血事件的器官中的细胞死亡的新型鱼油组合物。
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9.发明申请Use of an Omega-3 Lipid-Based Emulsion Following Ischemic Injury to Provide Protection and Recovery in Human Organs 审中-公开缺血性损伤后使用基于Omega-3的脂质乳剂，提供人体器官的保护和恢复公开(公告)号：US20140287004A1
公开(公告)日：2014-09-25
申请号：US14299440
申请日：2014-06-09
IPC分类号： A61K31/202 , A61K9/107
CPC分类号： A61K31/202 , A61K9/1075 , A61K31/22 , A61K35/60
摘要： The present invention provides methods of limiting cell death or damage or reperfusion damage resulting from hypoxic-ischemia, comprising administering an omega-3 triglyceride emulsion after a hypoxic-ischemia insult. The omega-3 triglyceride emulsion preferably comprises from about 7% to 35% omega-3 oil by weight in grams per 100 ml of emulsion; the omega-3 oil comprises about 20% to 100% triglyceride by weight per total weight of the omega-3 oil and about 20% wt.-% to 100% of the acyl-groups of the omega-3 triglycerides consist of DHA; the omega-3 oil comprises less than 10% omega-6 fatty acids; and the mean diameter of lipid droplets in the emulsion is less than about 5 microns.
摘要翻译： 本发明提供限制由缺氧缺血引起的细胞死亡或损伤或再灌注损伤的方法，包括在缺氧缺血损伤后施用ω-3甘油三酯乳剂。 ω-3甘油三酯乳液优选包含按重量计约7％至35％的ω-3油/克/ 100ml乳液; ω-3油包含占ω-3油总重量的约20％至100％的甘油三酯，ω-3甘油三酯的酰基基团约为20％重量百分比至100％由DHA组成; ω-3油包含小于10％的ω-6脂肪酸; 并且乳液中脂滴的平均直径小于约5微米。
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10.发明授权Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs 有权在缺血性损伤后使用基于ω-3脂质的乳剂，以在人体器官中提供保护和恢复公开(公告)号：US09084801B2
公开(公告)日：2015-07-21
申请号：US13336290
申请日：2011-12-23
IPC分类号： A61K35/60 , A61K31/202 , A61K31/22
CPC分类号： A61K31/232 , A61K9/107 , A61K31/202 , A61K31/22 , A61K35/60
摘要： The present invention provides methods of limiting cell death resulting from hypoxic-ischemia comprising, administering an omega-3 lipid-based emulsion after a hypoxic-ischemia insult. The omega-3 lipid-based emulsion preferably comprises at least 20% omega-3 oil, by weight, and wherein the omega-3 oil comprises at least 20% omega-3 triglycerides and/or diglycerides, and wherein fatty acids of the omega-3 trigylceride and/or diglycerides comprise at least 40% EPA and/or DHA. The present invention also provides novel fish-oil compositions for administration after an ischemic insult to limit cell death in the organ that underwent an ischemic event.
摘要翻译： 本发明提供限制由缺氧缺血引起的细胞死亡的方法，包括在缺氧缺血损伤后施用基于ω-3脂质的乳剂。 基于ω-3脂质的乳液优选包含至少20重量％的ω-3油，其中ω-3油包含至少20％的ω-3甘油三酯和/或甘油二酯，并且其中ω- -3甘油三酯和/或甘油二酯包含至少40％的EPA和/或DHA。 本发明还提供了用于在缺血性损伤之后施用以限制经历缺血事件的器官中的细胞死亡的新型鱼油组合物。
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