公开(公告)号：US20110312883A1

公开(公告)日：2011-12-22

申请号：US12946167

申请日：2010-11-15

申请人： Pia Runeberg-Roos ,  Maxim M. Bespalov ,  Richard Penn ,  Mart Saarma

发明人： Pia Runeberg-Roos ,  Maxim M. Bespalov ,  Richard Penn ,  Mart Saarma

IPC分类号： A61K38/17 ,  C07H21/00 ,  A61P25/28 ,  A61P15/10 ,  A61P25/16 ,  A61P3/10 ,  A61P9/10 ,  C07K14/435 ,  A61P25/02

CPC分类号： C07K14/475 ,  A61K38/00

摘要： Neurturin polypeptides which possess reduced heparin and heparan sulfate binding affinity but retain neurotrophic activity, nucleic acids which encode the neurturin variants and vectors and host cells which express the enhanced neurturin polypeptides. Use of the enhanced neurturin polypeptides, nucleic acids and host cells in the treatment or prevention of disease.

摘要翻译： 具有降低的肝素和硫酸乙酰肝素结合亲和力但保留神经营养活性的Neururin多肽，编码neururin变体的核酸和载体以及表达增强的neururin多肽的宿主细胞。 增强的neururin多肽，核酸和宿主细胞在治疗或预防疾病中的用途。

公开(公告)号：US08445432B2

公开(公告)日：2013-05-21

申请号：US12946167

申请日：2010-11-15

申请人： Richard Penn ,  Pia Runeberg-Roos ,  Maxim M. Bespalov ,  Mart Saarma

发明人： Richard Penn ,  Pia Runeberg-Roos ,  Maxim M. Bespalov ,  Mart Saarma

IPC分类号： A61K38/22 ,  A61P3/04

CPC分类号： C07K14/475 ,  A61K38/00

摘要： Neurturin polypeptides which possess reduced heparin and heparan sulfate binding affinity but retain neurotrophic activity, nucleic acids which encode the neurturin variants and vectors and host cells which express the enhanced neurturin polypeptides. Use of the enhanced neurturin polypeptides, nucleic acids and host cells in the treatment or prevention of disease.