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公开(公告)号：US07276579B2
公开(公告)日：2007-10-02
申请号：US10450637
申请日：2001-12-27
IPC分类号： C07K2/00
CPC分类号： A61K39/21 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C07K14/005 , C07K14/70503 , C07K14/7158 , C07K16/1063 , C12N2740/16122 , C12N2740/16134
摘要： An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The immunogenic transmembrane protein is bound to a ligand which is anchored in the shape. Methods for making the immunogenic proteoliposomes are provided uses of the proteoliposome are described, including their use as immunogens to elicit immune reaction, and their use in screening assays, including their use as antigens to screen antibody libraries, as well as for drug screening and the identification of ligands.
摘要翻译： 含有跨膜蛋白或包含病毒包膜糖蛋白的蛋白质的寡聚复合物的免疫原性蛋白脂质体在围绕椭圆形或球形的脂质膜中。 该形状优选还含有引诱剂如链霉抗生物素蛋白或抗生物素蛋白，并且脂质膜含有结合引诱剂如生物素的部分。 免疫原性跨膜蛋白与锚定在该形状的配体结合。 提供了制备免疫原性蛋白脂质体的方法，描述了脂蛋白体的用途，包括其作为免疫原用于引发免疫反应的用途，以及它们在筛选测定中的应用，包括其用作抗体筛选抗体文库以及用于药物筛选和 鉴定配体。
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公开(公告)号：US07741024B2
公开(公告)日：2010-06-22
申请号：US11781998
申请日：2007-07-24
CPC分类号： A61K39/21 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C07K14/005 , C07K14/70503 , C07K14/7158 , C07K16/1063 , C12N2740/16122 , C12N2740/16134
摘要： An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The immunogenic transmembrane protein is bound to a ligand which is anchored in the shape. Methods for making the immunogenic proteoliposomes are provided. uses of the proteoliposome are described, including their use as immunogens to elicit immune reaction, and their use in screening assays, including their use as antigens to screen antibody libraries, as well as for drug screening and the identification of ligands.
摘要翻译： 含有跨膜蛋白或包含病毒包膜糖蛋白的蛋白质的寡聚复合物的免疫原性蛋白脂质体在围绕椭圆形或球形的脂质膜中。 该形状优选还含有引诱剂如链霉抗生物素蛋白或抗生物素蛋白，并且脂质膜含有结合引诱剂如生物素的部分。 免疫原性跨膜蛋白与锚定在该形状的配体结合。 提供了制备免疫原性蛋白脂质体的方法。 描述了蛋白脂质体的用途，包括它们作为免疫原用于引发免疫反应的用途，以及它们在筛选测定中的应用，包括其用作抗体筛选抗体文库，以及用于药物筛选和鉴定配体。
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3.发明授权Proteoliposomes containing an integral membrane protein having one or more transmembrane domains 有权含有具有一个或多个跨膜结构域的整合膜蛋白的蛋白脂质体公开(公告)号：US06761902B2
公开(公告)日：2004-07-13
申请号：US09749240
申请日：2000-12-27
IPC分类号： A61K9127
CPC分类号： B82Y30/00 , A61K9/1271 , A61K9/1277
摘要： A stable proteoliposome containing an integral membrane protein in a lipid membrane around an elliptoid or spherical shape. The shape preferably contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The integral membrane protein is bound to a ligand which is anchored in the shape. Methods for making the proteoliposomes are provided. Kits for making the proteoliposome are described, as are the uses of the proteoliposome.
摘要翻译： 一种稳定的蛋白脂质体，其在椭圆体或球形周围的脂质膜中含有整合的膜蛋白。 该形状优选含有引诱剂如链霉抗生物素蛋白或抗生物素蛋白，并且脂质膜含有结合引诱剂例如生物素的部分。 整合膜蛋白结合到锚定在该形状上的配体。 提供了制备蛋白脂质体的方法。 描述了用于制备蛋白脂质体的试剂盒，以及蛋白脂质体的用途。
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公开(公告)号：US20070292436A1
公开(公告)日：2007-12-20
申请号：US11781998
申请日：2007-07-24
CPC分类号： A61K39/21 , A61K39/12 , A61K39/39 , A61K47/6911 , A61K2039/545 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C07K14/005 , C07K14/70503 , C07K14/7158 , C07K16/1063 , C12N2740/16122 , C12N2740/16134
摘要： An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant such as streptavidin or avidin and the lipid membrane contains a moiety that binds to the attractant such as biotin. The immunogenic transmembrane protein is bound to a ligand which is anchored in the shape. Methods for making the immunogenic proteoliposomes are provided. uses of the proteoliposome are described, including their use as immunogens to elicit immune reaction, and their use in screening assays, including their use as antigens to screen antibody libraries, as well as for drug screening and the identification of ligands.
摘要翻译： 含有跨膜蛋白或包含病毒包膜糖蛋白的蛋白质的寡聚复合物的免疫原性蛋白脂质体在围绕椭圆形或球形的脂质膜中。 该形状优选还含有引诱剂如链霉抗生物素蛋白或抗生物素蛋白，并且脂质膜含有结合引诱剂如生物素的部分。 免疫原性跨膜蛋白与锚定在该形状的配体结合。 提供了制备免疫原性蛋白脂质体的方法。 描述了蛋白脂质体的用途，包括它们作为免疫原用于引发免疫反应的用途，以及它们在筛选测定中的应用，包括其用作抗体筛选抗体文库，以及用于药物筛选和鉴定配体。
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