公开(公告)号：US20120052082A1

公开(公告)日：2012-03-01

申请号：US13084367

申请日：2011-04-11

申请人： Richard W. Compans ,  Sang-Moo Kang ,  Jadranka Bozja ,  Bao-Zhong Wang ,  Jae-Min Song

发明人： Richard W. Compans ,  Sang-Moo Kang ,  Jadranka Bozja ,  Bao-Zhong Wang ,  Jae-Min Song

IPC分类号： A61K39/145 ,  A61P31/16 ,  A61P37/04

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/58 ,  C12N2760/16134 ,  C12N2760/16142

摘要： A cross-protective influenza virus vaccine has been designed based on the incorporation of the genetically engineered, highly conserved M2 influenza viral protein optionally in combination with an adjuvant such as a bacterial flagellin protein incorporated into the membrane of a virosome or virus-like particles. Immunogenicity and the breadth of cross protection efficacy are significantly enhanced using multiple copies of the influenza M2 protein as a membrane bound tetramer and/or in combination with a membrane bound adjuvant. A method for vaccinating a subject for influenza A has also been developed that results in broad and improved cross-protection against multiple subtypes of influenza A virus.

摘要翻译： 已经基于将经遗传工程化的高度保守的M2流感病毒蛋白质掺入到病毒颗粒或病毒样颗粒的膜中的佐剂（例如细菌鞭毛蛋白）组合来设计交叉保护型流感病毒疫苗。 使用多个拷贝的流感M2蛋白作为膜结合的四聚体和/或与膜结合的佐剂组合，可以显着增强免疫原性和交叉保护功效的广度。 还开发了用于接种甲型流感病毒的受试者的方法，其导致广泛和改进的针对多种亚型甲型流感病毒的交叉保护。