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1.发明授权Human growth hormone receptor antagonist antibodies and methods of use thereof 有权人生长激素受体拮抗剂抗体及其使用方法公开(公告)号：US09249224B2
公开(公告)日：2016-02-02
申请号：US14367483
申请日：2012-12-10
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Sara Iva Siebel , Edward Derrick Pascua , Chia-Yang Lin , Javier Fernando Chaparro Riggers
IPC: C07K16/28 , A61K39/395 , A61K39/00
CPC classification number: C07K16/2869 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation.
Abstract translation: 本发明提供了与生长激素受体（GHR）结合的拮抗性抗体。 本发明还涉及使用这些抗体降低IGF-1水平和/或用于治疗和/或预防与过量IGF-1相关的疾病的治疗方法，包括治疗肢端肥大症，巨人症，癌症，糖尿病性肾病，关节炎 ，和肺部炎症。
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公开(公告)号：US11198735B2
公开(公告)日：2021-12-14
申请号：US16488040
申请日：2018-02-21
Applicant: Rinat Neuroscience Corp.
Inventor： Samantha Lisa Bucktrout , Bevin Marie Brady Smith , Edward Derrick Pascua , Javier Fernando Chaparro Riggers
Abstract: The present invention provides antibodies that bind Glucocorticoid Induced Tumor necrosis factor Receptor family related protein (GITR) and methods of using same. The anti-GITR antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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3.发明申请HUMAN GROWTH HORMONE RECEPTOR ANTAGONIST ANTIBODIES AND METHODS OF USE THEREOF 审中-公开人生长激素受体拮抗剂抗体及其使用方法公开(公告)号：US20140356359A1
公开(公告)日：2014-12-04
申请号：US14367483
申请日：2012-12-10
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Sara Iva Siebel , Edward Derrick Pascua , Chia-Yang Lin , Javier Fernando Chaparro Riggers
IPC: C07K16/28
CPC classification number: C07K16/2869 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation.
Abstract translation: 本发明提供了与生长激素受体（GHR）结合的拮抗性抗体。 本发明还涉及使用这些抗体降低IGF-1水平和/或用于治疗和/或预防与过量IGF-1相关的疾病的治疗方法，包括治疗肢端肥大症，巨人症，癌症，糖尿病性肾病，关节炎 ，和肺部炎症。
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