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公开(公告)号：US09175093B2
公开(公告)日：2015-11-03
申请号：US13857063
申请日：2013-04-04
Applicant: RINAT NEUROSCIENCE CORP. , PFIZER INC.
Inventor： Hong Liang , Yasmina Noubia Abdiche , Javier Fernando Chaparro Riggers , Bruce Charles Gomes , Julie Jia Li Hawkins , Jaume Pons , Xiayang Qiu , Pavel Strop , Yuli Wang
IPC: A61K39/395 , C07K16/40 , A61K45/06 , A61K39/00
CPC classification number: C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
Abstract translation: 本发明提供了与抗蛋白转化酶枯草杆菌蛋白酶Kexin 9型（PCSK9）结合的拮抗抗体，其抗原结合部分和适体。 还提供了针对肽的抗体，其中抗体结合PCSK9。 本发明还提供了获得这样的抗体和抗体编码核酸的方法。 本发明还涉及使用这些抗体及其抗原结合部分来降低LDL-胆固醇水平和/或用于治疗和/或预防心血管疾病（包括治疗高胆固醇血症）的治疗方法。
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公开(公告)号：US08715673B2
公开(公告)日：2014-05-06
申请号：US13719214
申请日：2012-12-18
Applicant: Rinat Neuroscience Corp.
Inventor： Davide Luciano Foletti , Javier Fernando Chaparro Riggers , Jacob Eli Gunn Glanville , Lee Mary Beth Shaughnessy , David Louis Shelton , Pavel Strop , Wenwu Zhai
IPC: A61K39/40
CPC classification number: C07K16/1271 , A61K39/40 , A61K2039/505 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.
Abstract translation: 本发明提供了结合金黄色葡萄球菌α-毒素的拮抗性抗体。 本发明还提供了获得这样的抗体和编码抗体的核酸的方法。 本发明还涉及用于这些抗体用于治疗和/或预防葡萄球菌疾病（包括例如肺炎，菌血症，败血症，眼睛感染和脓肿）的治疗方法。
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Patent Agency Ranking
3.发明授权公开(公告)号：US09248189B2
公开(公告)日：2016-02-02
申请号：US14268933
申请日：2014-05-02
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Alison Jane Forgie , Javier Fernando Chaparro Riggers , Edward Roland Lavallie , Chia-Yang Lin , Lidia Mosyak , Andrea Rossi , Thomas John Van Blarcom
IPC: A61K45/06 , A61K31/155 , A61K39/395 , C07K16/28 , A61K39/00
CPC classification number: C07K16/2869 , A61K31/155 , A61K31/4353 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/33 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to glucagon receptor and methods of using same. The anti-glucagon receptor antibodies can be used therapeutically to lower glucose levels in blood, and can be in the prevention and/or treatment of glucose-related disorders, including diabetes, hyperglycemia, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, dyslipidemia, or metabolic syndrome.
Abstract translation: 本发明提供了结合胰高血糖素受体的拮抗性抗体及其使用方法。 抗胰高血糖素受体抗体可用于治疗降低血液中的葡萄糖水平，并可用于预防和/或治疗葡萄糖相关疾病，包括糖尿病，高血糖症，高胰岛素血症，空腹血糖受损，葡萄糖耐量异常，血脂异常， 或代谢综合征。
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公开(公告)号：US11198735B2
公开(公告)日：2021-12-14
申请号：US16488040
申请日：2018-02-21
Applicant: Rinat Neuroscience Corp.
Inventor： Samantha Lisa Bucktrout , Bevin Marie Brady Smith , Edward Derrick Pascua , Javier Fernando Chaparro Riggers
Abstract: The present invention provides antibodies that bind Glucocorticoid Induced Tumor necrosis factor Receptor family related protein (GITR) and methods of using same. The anti-GITR antibodies can be used therapeutically alone or in combination with other therapeutics to treat cancer and other diseases.
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公开(公告)号：US20160311912A1
公开(公告)日：2016-10-27
申请号：US14976301
申请日：2015-12-21
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Alison Jane Forgie , Javier Fernando Chaparro Riggers , Edward Roland Lavallie , Chia-Yang Lin , Lidia Mosyak , Andrea Rossi , Thomas John Van Blarcom
IPC: C07K16/28 , A61K31/4353 , A61K39/395
CPC classification number: C07K16/2869 , A61K31/155 , A61K31/4353 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/33 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to glucagon receptor and methods of using same. The anti-glucagon receptor antibodies can be used therapeutically to lower glucose levels in blood, and can be in the prevention and/or treatment of glucose-related disorders, including diabetes, hyperglycemia, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, dyslipidemia, or metabolic syndrome.
Abstract translation: 本发明提供了结合胰高血糖素受体的拮抗性抗体及其使用方法。 抗胰高血糖素受体抗体可用于治疗降低血液中的葡萄糖水平，并可用于预防和/或治疗葡萄糖相关疾病，包括糖尿病，高血糖症，高胰岛素血症，空腹血糖受损，葡萄糖耐量异常，血脂异常， 或代谢综合征。
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6.发明申请HUMAN GROWTH HORMONE RECEPTOR ANTAGONIST ANTIBODIES AND METHODS OF USE THEREOF 审中-公开人生长激素受体拮抗剂抗体及其使用方法公开(公告)号：US20140356359A1
公开(公告)日：2014-12-04
申请号：US14367483
申请日：2012-12-10
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Sara Iva Siebel , Edward Derrick Pascua , Chia-Yang Lin , Javier Fernando Chaparro Riggers
IPC: C07K16/28
CPC classification number: C07K16/2869 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation.
Abstract translation: 本发明提供了与生长激素受体（GHR）结合的拮抗性抗体。 本发明还涉及使用这些抗体降低IGF-1水平和/或用于治疗和/或预防与过量IGF-1相关的疾病的治疗方法，包括治疗肢端肥大症，巨人症，癌症，糖尿病性肾病，关节炎 ，和肺部炎症。
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7.发明授权Human growth hormone receptor antagonist antibodies and methods of use thereof 有权人生长激素受体拮抗剂抗体及其使用方法公开(公告)号：US09249224B2
公开(公告)日：2016-02-02
申请号：US14367483
申请日：2012-12-10
Applicant: RINAT NEUROSCIENCE CORP.
Inventor： Sara Iva Siebel , Edward Derrick Pascua , Chia-Yang Lin , Javier Fernando Chaparro Riggers
IPC: C07K16/28 , A61K39/395 , A61K39/00
CPC classification number: C07K16/2869 , A61K39/39558 , A61K2039/505 , C07K16/2863 , C07K2317/24 , C07K2317/41 , C07K2317/76 , C07K2317/92 , A61K2300/00
Abstract: The present invention provides antagonizing antibodies that bind to growth hormone receptor (GHR). The invention further relates to therapeutic methods for use of these antibodies to reduce IGF-1 levels and/or for the treatment and/or prevention of diseases associated with excessive IGF-1, including treatment of acromegaly, gigantism, cancer, diabetic nephropathy, arthritis, and lung inflammation.
Abstract translation: 本发明提供了与生长激素受体（GHR）结合的拮抗性抗体。 本发明还涉及使用这些抗体降低IGF-1水平和/或用于治疗和/或预防与过量IGF-1相关的疾病的治疗方法，包括治疗肢端肥大症，巨人症，癌症，糖尿病性肾病，关节炎 ，和肺部炎症。
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