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公开(公告)号：US07084109B2
公开(公告)日：2006-08-01
申请号：US10202915
申请日：2002-07-25
CPC分类号： C07K7/08 , A61K38/00 , Y10S514/824
摘要： This invention provides novel compounds which prevent or block a FVIIa mediated or associated process or event such as the catalytic conversion of FX to FXa, FVII to FVIIa or FIX to FIXa. In particular aspects, the compounds of the invention bind Factor VIIa (FVIIa), its zymogen Factor VII (FVII) and/or block the association of FVII or FVIIa with a peptide compound of the present invention. The invention also provides pharmaceutical compositions comprising the novel compounds as well as their use in diagnostic, therapeutic, and prophylactic methods.
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公开(公告)号：US5880256A
公开(公告)日：1999-03-09
申请号：US399115
申请日：1995-03-03
申请人： Mark S. Dennis , Robert A. Lazarus
发明人： Mark S. Dennis , Robert A. Lazarus
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K38/48 , A61P7/02 , C07H21/04 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/15 , C12P21/02 , C12R1/19 , A61K38/55
CPC分类号： C07K14/8114 , A61K38/00 , Y10S514/822
摘要： A potent serine protease inhibitor capable of inhibiting Factor VIIa, Factor XIa, plasma kallikrein, or plasmin is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor VIIa, Factor XIa, plasma kallikrein, or plasmin is indicated.
摘要翻译： 提供能够抑制因子VIIa，因子XIa，血浆激肽释放酶或纤溶酶的强效丝氨酸蛋白酶抑制剂。 抑制剂提供在用于治疗其中指示因子VIIa，因子XIa，血浆激肽释放酶或纤溶酶的抑制的疾病的药物组合物中。
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公开(公告)号：US5795954A
公开(公告)日：1998-08-18
申请号：US206310
申请日：1994-03-04
申请人： Robert A. Lazarus , Mark S. Dennis
发明人： Robert A. Lazarus , Mark S. Dennis
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K38/48 , A61P7/02 , C07H21/04 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/15 , C12P21/02 , C12R1/19 , A61K38/16 , A61K38/57
CPC分类号： C07K14/8114 , A61K38/00 , Y10S514/822
摘要： A potent serine protease inhibitor capable of inhibiting Factor VIIa, Factor XIa, plasma kallikrein, and plasmin is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor VIIa, Factor XIa, plasma kallikrein, or plasmin is indicated.
摘要翻译： 提供能够抑制因子VIIa，因子XIa，血浆激肽释放酶和纤溶酶的强效丝氨酸蛋白酶抑制剂。 抑制剂提供在用于治疗其中指示因子VIIa，因子XIa，血浆激肽释放酶或纤溶酶的抑制的疾病的药物组合物中。
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公开(公告)号：US5780265A
公开(公告)日：1998-07-14
申请号：US463155
申请日：1995-06-05
申请人： Mark S. Dennis , Robert A. Lazarus
发明人： Mark S. Dennis , Robert A. Lazarus
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K38/55 , A61P7/00 , A61P9/00 , A61P9/02 , C07K14/47 , C07K14/81 , C12N9/99 , C12N15/15 , C12P21/02 , C12P21/06 , C07H21/04 , C12N15/63
CPC分类号： C07K14/8114 , A61K38/00
摘要： Potent and specific serine protease inhibitors are provided that are capable of inhibiting plasma kallikrein. The inhibitors are provided in pharmaceutical compositions for the treatment of diseases and disorders where inhibition of plasma kallikrein in indicated.
摘要翻译： 提供能够抑制血浆激肽释放酶的强力和特异性丝氨酸蛋白酶抑制剂。 抑制剂提供于用于治疗所指示的血浆激肽释放酶抑制的疾病和病症的药物组合物中。
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公开(公告)号：US5863893A
公开(公告)日：1999-01-26
申请号：US398628
申请日：1995-03-03
申请人： Mark S. Dennis , Robert A. Lazarus
发明人： Mark S. Dennis , Robert A. Lazarus
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K38/48 , A61P7/02 , C07H21/04 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/15 , C12P21/02 , C12R1/19 , A61K38/55 , A61K38/57 , C12N9/64
CPC分类号： C07K14/8114 , A61K38/00 , Y10S514/822
摘要： A potent serine protease inhibitor capable of inhibiting Factor VIIa, Factor XIa, plasma kallikrein, or plasmin is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor VIIa, Factor XIa, plasma kallikrein, or plasmin is indicated.
摘要翻译： 提供能够抑制因子VIIa，因子XIa，血浆激肽释放酶或纤溶酶的强效丝氨酸蛋白酶抑制剂。 抑制剂提供在用于治疗其中指示因子VIIa，因子XIa，血浆激肽释放酶或纤溶酶的抑制的疾病的药物组合物中。
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公开(公告)号：US5834244A
公开(公告)日：1998-11-10
申请号：US398010
申请日：1995-03-03
申请人： Mark S. Dennis , Robert A. Lazarus
发明人： Mark S. Dennis , Robert A. Lazarus
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K38/48 , A61P7/02 , C07H21/04 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/15 , C12P21/02 , C12R1/19 , C12N15/63
CPC分类号： C07K14/8114 , A61K38/00 , Y10S514/822
摘要： A potent serine protease inhibitor capable of inhibiting Factor VIIa, Factor XIa, plasma kallikrein, or plasmin is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor VIIa, Factor XIa, plasma kallikrein, or plasmin is indicated.
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公开(公告)号：US5719041A
公开(公告)日：1998-02-17
申请号：US439534
申请日：1995-05-11
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K38/55 , A61P7/04 , A61P31/04 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/31 , C12P21/02 , C07H21/04 , C12N15/63
CPC分类号： C07K14/811 , A61K38/00
摘要： A potent serine protease inhibitor capable of inhibiting Factor Xa, Factor XIIa, plasma kallikrein, and human leukocyte elastase is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor Xa, Factor XIIa, plasma kallikrein, or HLE is indicated.
摘要翻译： 提供能够抑制因子Xa，因子XIIa，血浆激肽释放酶和人白细胞弹性蛋白酶的强效丝氨酸蛋白酶抑制剂。 抑制剂提供在用于治疗其中指示因子Xa，因子XIIa，血浆激肽释放酶或HLE的抑制的疾病的药物组合物中。
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公开(公告)号：US6113896A
公开(公告)日：2000-09-05
申请号：US319501
申请日：1994-10-04
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K38/55 , A61P7/04 , A61P31/04 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/31 , C12P21/02 , C12N9/48
CPC分类号： C07K14/811 , A61K38/00
摘要： A potent serine protease inhibitor capable of inhibiting Factor Xa, Factor XIIa, plasma kallikrein, and human leukocyte elastase is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor Xa, Factor XIIa, plasma kallikrein, or HLE is indicated.
摘要翻译： 提供能够抑制因子Xa，因子XIIa，血浆激肽释放酶和人白细胞弹性蛋白酶的强效丝氨酸蛋白酶抑制剂。 抑制剂提供在用于治疗其中指示因子Xa，因子XIIa，血浆激肽释放酶或HLE的抑制的疾病的药物组合物中。
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公开(公告)号：US5843895A
公开(公告)日：1998-12-01
申请号：US439005
申请日：1995-05-11
IPC分类号： C12N15/09 , A61K38/00 , A61K38/43 , A61K38/55 , A61P7/04 , A61P31/04 , C07K14/81 , C12N1/21 , C12N9/99 , C12N15/31 , C12P21/02
CPC分类号： C07K14/811 , A61K38/00
摘要： A potent serine protease inhibitor capable of inhibiting Factor Xa, Factor XIIa, plasma kallikrein, and human leukocyte elastase is provided. The inhibitor is provided in a pharmaceutical composition for treatment of diseases where inhibition of Factor Xa, Factor XIIa, plasma kallikrein, or HLE is indicated.
摘要翻译： 提供能够抑制因子Xa，因子XIIa，血浆激肽释放酶和人白细胞弹性蛋白酶的强效丝氨酸蛋白酶抑制剂。 抑制剂提供在用于治疗其中指示因子Xa，因子XIIa，血浆激肽释放酶或HLE的抑制的疾病的药物组合物中。
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公开(公告)号：US5786328A
公开(公告)日：1998-07-28
申请号：US463432
申请日：1995-06-05
申请人： Mark S. Dennis , Robert A. Lazarus
发明人： Mark S. Dennis , Robert A. Lazarus
CPC分类号： C07K14/8114 , A61K38/00
摘要： Potent and specific serine protease inhibitors are provided that are capable of inhibiting plasma kallikrein. The inhibitors are provided in pharmaceutical compositions for the treatment of diseases and disorders where inhibition of plasma kallikrein in indicated.
摘要翻译： 提供能够抑制血浆激肽释放酶的强力和特异性丝氨酸蛋白酶抑制剂。 抑制剂提供于用于治疗所指示的血浆激肽释放酶抑制的疾病和病症的药物组合物中。
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