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5 条记录 (耗时 0.012 秒)

    Inhibition of cell surface protein disulfide isomerase
    1.
    发明授权
    Inhibition of cell surface protein disulfide isomerase 失效
    抑制细胞表面蛋白二硫键异构酶

    公开(公告)号：US06949665B2

    公开(公告)日：2005-09-27

    申请号：US10002698

    申请日：2001-12-05

    申请人： Snezna Rogelj ,  Larry A. Sklar ,  Robert B. Palmer

    发明人： Snezna Rogelj ,  Larry A. Sklar ,  Robert B. Palmer

    IPC分类号： A61K31/285 ,  A61K31/42 ,  A61K31/555 ,  C07F9/70

    CPC分类号： A61K31/555 ,  A61K31/285 ,  A61K31/42

    摘要： The invention provides anti-thiol reagents which inhibit enzyme activity of cell-associated protein disulfide isomerase (PDI) by oxidizing or blocking PDI active site vicinal thiol groups which normally participate in disulfide bond rearrangement of PDI substrates. Inhibition of this PDI function is particularly useful in blocking PDI-mediated entry of HIV or other virions into a host cell, as well as inhibiting lymphocyte traffic through the lymph nodes. The invention further provides an assay for the identification of such PDI inhibitors based on the discovery that inhibitors of the invention also induce shedding of the leucocyte L-selectin adhesion molecule.

    摘要翻译： 本发明提供通过氧化或阻断通常参与PDI底物的二硫键重排的PDI活性位点连位硫醇基团来抑制细胞相关蛋白二硫键异构酶（PDI）的酶活性的抗硫醇试剂。 该PDI功能的抑制特别可用于阻断PDI介导的HIV或其它病毒体进入宿主细胞，以及抑制通过淋巴结的淋巴细胞流量。 基于本发明的抑制剂还诱导白细胞L-选择素粘附分子的脱落的发现，本发明还提供了用于鉴定这种PDI抑制剂的测定法。

    Charged particle accelerator grating
    2.
    依法登记的发明
    Charged particle accelerator grating 失效

    公开(公告)号：USH116H

    公开(公告)日：1986-09-02

    申请号：US773755

    申请日：1985-09-09

    申请人： Robert B. Palmer

    发明人： Robert B. Palmer

    IPC分类号： G21K1/00 ,  H01J3/14 ,  H05H9/00

    CPC分类号： G21K1/00 ,  H01J3/14 ,  H05H9/00

    摘要： A readily disposable and replaceable accelerator grating for a relativistic particle accelerator. The grating is formed for a plurality of liquid droplets that are directed in precisely positioned jet streams to periodically dispose rows of droplets along the borders of a predetermined particle beam path. A plurality of lasers are used to direct laser beams into the droplets, at predetermined angles, thereby to excite the droplets to support electromagnetic accelerating resonances on their surfaces. Those resonances operate to accelerate and focus particles moving along the beam path. As the droplets are distorted or destroyed by the incoming radiation, they are replaced at a predetermined frequency by other droplets supplied through the jet streams.

    Radio frequency accelerating cavity having slotted irises for damping certain electromagnetic modes
    5.
    发明授权
    Radio frequency accelerating cavity having slotted irises for damping certain electromagnetic modes 失效
    射频加速腔具有用于阻尼某些电磁模式的开槽虹膜

    公开(公告)号：US5017881A

    公开(公告)日：1991-05-21

    申请号：US364304

    申请日：1989-06-12

    申请人： Robert B. Palmer

    发明人： Robert B. Palmer

    IPC分类号： H01J23/24 ,  H01J23/30

    CPC分类号： H01J23/24 ,  H01J23/30

    摘要： An accelerating cavity having one or more iris structures mounted therein for strongly damping unwanted frequencies that are generated in the cavity by bunches of particles in a particle beam that is accelerated through the cavity during its operation. Each of the iris structures is characterized by containing a plurality of radial slots therein that extend from the central aperture through the iris member to the perimeter thereof. The outer end of each of the radial slots includes an enlarged portion that is effective to prevent undesired frequencies from being reflected back into the center aperture of the iris member. Waveguide means connect the outer ends of the radial slots to frequency damping means or to a dump or dumps.

    摘要翻译： 具有安装在其中的一个或多个虹膜结构的加速腔，用于通过在其操作期间加速通过空腔的粒子束中的一束粒子来强烈地阻止在空腔中产生的不期望的频率。 每个虹膜结构的特征在于在其中包含多个径向槽，其中心孔从中心孔延伸通过虹膜构件到其周边。 每个径向狭槽的外端部包括有效地防止不期望的频率被反射回到虹膜构件的中心孔中的扩大部分。 波导装置将径向槽的外端连接到频率阻尼装置或者转储或倾倒。