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公开(公告)号：US20060135576A1
公开(公告)日：2006-06-22
申请号：US11349767
申请日：2006-02-08
申请人： Robert Borzilleri , Rajeev Bhide , John Tokarski , Peter Zheng , Ligang Qian , Zhen-Wei Cai
发明人： Robert Borzilleri , Rajeev Bhide , John Tokarski , Peter Zheng , Ligang Qian , Zhen-Wei Cai
IPC分类号： A61K31/426 , A61K31/421
CPC分类号： C07D277/42 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：US20060128709A1
公开(公告)日：2006-06-15
申请号：US11345845
申请日：2006-02-02
申请人： John Hunt , Rajeev Bhide , Robert Borzilleri , Ligang Qian
发明人： John Hunt , Rajeev Bhide , Robert Borzilleri , Ligang Qian
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D519/00 , C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：US20060004007A1
公开(公告)日：2006-01-05
申请号：US11190412
申请日：2005-07-27
申请人： John Hunt , Rajeev Bhide , Robert Borzilleri , Ligang Qian
发明人： John Hunt , Rajeev Bhide , Robert Borzilleri , Ligang Qian
IPC分类号： A61K31/53
CPC分类号： C07D519/00 , C07D487/04
摘要： The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：US20070117802A1
公开(公告)日：2007-05-24
申请号：US11521035
申请日：2006-09-14
申请人： Robert Borzilleri , Zhen-wei Cai , Donna Wei , John Tokarski
发明人： Robert Borzilleri , Zhen-wei Cai , Donna Wei , John Tokarski
IPC分类号： A61K31/53 , A61K31/519 , C07D487/04 , C07D491/02
CPC分类号： C07D213/75 , C07D471/04
摘要： The invention is directed to compounds that are useful for the treatment of cancer having the following Formula:
摘要翻译： 本发明涉及可用于治疗具有下式的癌症的化合物：
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公开(公告)号：US20060211695A1
公开(公告)日：2006-09-21
申请号：US11292358
申请日：2005-12-01
申请人： Robert Borzilleri , Zhong Chen , Tram Huynh , Wayne Vaccaro , Xiao-Tao Chen , Kyoung Kim , Zhen-wei Cai
发明人： Robert Borzilleri , Zhong Chen , Tram Huynh , Wayne Vaccaro , Xiao-Tao Chen , Kyoung Kim , Zhen-wei Cai
IPC分类号： A61K31/53 , A61K31/52 , A61K31/519 , C07D498/02 , C07D487/02 , C07D473/02
CPC分类号： C07D487/04 , C07D471/04 , C07D495/04
摘要： In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
摘要翻译： 通常，本发明包括式I和II的化合物，包括其药学上可接受的盐。 本发明的化合物可用作蛋白激酶抑制剂，因此可用于治疗癌症和其它蛋白激酶介导的疾病。
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公开(公告)号：US20050239820A1
公开(公告)日：2005-10-27
申请号：US11113838
申请日：2005-04-25
申请人： Robert Borzilleri , Kyoung Kim , Zhen-Wei Cai
发明人： Robert Borzilleri , Kyoung Kim , Zhen-Wei Cai
IPC分类号： A61K31/4745 , C07D471/02 , C07D471/04
CPC分类号： C07D471/04
摘要： The compounds of the instant invention can be used as anticancer agents. More specifically, the invention comprises a compound having Formula I or II,
摘要翻译： 本发明的化合物可用作抗癌剂。 更具体地，本发明包括具有式I或II的化合物，
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公开(公告)号：US20070123534A1
公开(公告)日：2007-05-31
申请号：US11605168
申请日：2006-11-28
申请人： Zhen-Wei Cai , Kyoung Kim , Robert Borzilleri
发明人： Zhen-Wei Cai , Kyoung Kim , Robert Borzilleri
IPC分类号： A61K31/53 , C07D487/04
CPC分类号： C07D487/04
摘要： In general, the instant invention comprises compounds having Formulae I and II: including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
摘要翻译： 通常，本发明包括具有式I和II的化合物：包括其药学上可接受的盐。 本发明的化合物可用作蛋白激酶抑制剂，因此可用于治疗癌症和其它蛋白激酶介导的疾病。
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公开(公告)号：US20050288290A1
公开(公告)日：2005-12-29
申请号：US11167043
申请日：2005-06-24
申请人： Robert Borzilleri , Zhong Chen , Tram Huynh , Wayne Vaccaro , Xiao-Tao Chen , Kyoung Kim , Zhen-wei Cai
发明人： Robert Borzilleri , Zhong Chen , Tram Huynh , Wayne Vaccaro , Xiao-Tao Chen , Kyoung Kim , Zhen-wei Cai
IPC分类号： A61K31/519 , A61K31/52 , A61K31/53 , C07D471/04 , C07D473/14 , C07D487/02 , C07D487/04 , C07D495/04
CPC分类号： C07D471/04 , C07D473/00 , C07D473/30 , C07D487/04 , C07D495/04
摘要： In general, the instant invention comprises compounds of Formulas I and II including pharmaceutically acceptable salts thereof. The compounds of the invention are useful as protein kinase inhibitors and therefore are useful for treating cancer and other protein kinase mediated diseases.
摘要翻译： 通常，本发明包括式I和II的化合物，包括其药学上可接受的盐。 本发明的化合物可用作蛋白激酶抑制剂，因此可用于治疗癌症和其它蛋白激酶介导的疾病。
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公开(公告)号：US20050234060A1
公开(公告)日：2005-10-20
申请号：US11157890
申请日：2005-06-21
申请人： Rajeev Bhide , Robert Borzilleri
发明人： Rajeev Bhide , Robert Borzilleri
CPC分类号： C07D487/04 , A61K31/53 , A61K45/06 , A61K2300/00
摘要： The present invention provides compounds of formula I, and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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公开(公告)号：US20070078140A1
公开(公告)日：2007-04-05
申请号：US11529875
申请日：2006-09-28
IPC分类号： A61K31/506 , A61K31/501 , A61K31/4965 , A61K31/497 , C07D403/04
CPC分类号： C07D401/12 , C07D213/82 , C07D471/04
摘要： The present invention is directed to compounds having the formula I or II: including salts thereof, and methods for using them for the treatment of cancer.
摘要翻译： 本发明涉及具有式I或II的化合物：包括其盐，以及用于治疗癌症的方法。
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