摘要:
There is provided a novel vascular endothelial growth factor, herein designated VEGF-X, in addition to the nucleic acid molecule encoding it, a host cell transformed with said vector and compounds which inhibit or enhance angiogenesis. Also provided is the sequence of a CUB domain present in the sequence of VEGF-X which domain itself prevents angiogenesis and which is used to treat diseases associated with inappropriate vascularisation or angiogenesis.
摘要:
There is provided a novel vascular endothelial growth factor, herein designated VEGF-X, in addition to the nucleic acid molecule encoding it, a host cell transformed with said vector and compounds which inhibit or enhance angiogenesis. Also provided is the sequence of a CUB domain present in the sequence of VEGF-X which domain itself prevents angiogenesis and which is used to treat diseases associated with inappropriate vascularisation or angiogenesis.
摘要:
An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.
摘要:
A computer system generates transition effects for use on a visual display. The system includes a binary table for describing a transition effect and a method for ordering the rows in the table to produce the transition. The table includes an arbitrary number of rows, each row representing a cell (group of picture elements) on the display. A numerical value, based on any function of cell location, is associated with each cell. The table is then sorted according to the numerical values. Each row in the sorted table drives a step in the transition effect. The cells described by the various rows are changed in sorted order to display the material from the image being transitioned-to. The sequence of processing of the rows causes the desired transition effect. By varying the function used to order the rows, an infinite variety of transition effects can be created.
摘要:
Method and apparatus for generating relative movement between a first image and a second image while avoiding display screen flicker. The method includes a step of copying to a first buffer a portion of a display memory corresponding to a present portion of the second image wherein a first image will first appear. The method further includes the steps of superimposing within the display memory the first image upon the present portion of the second image and copying to a second buffer the portion of the display memory corresponding to the present portion of the second image, including the first image superimposed thereon, and a portion of the display memory corresponding to a next portion of the second image wherein the first image will next appear. The method further includes the steps of erasing the first image from the second buffer by copying the present portion from the first buffer to the second buffer and superimposing, within the second buffer, the first image upon the next portion of the second image. The method includes a further step of copying the second buffer to the display memory such that the first image disappears from the present portion of the second image while simultaneously appearing within the next portion of the second image, thereby avoiding display screen flicker.
摘要:
A method for synchronizing common values in a distributed system, at least one node of which is a cyclic, rule-based, object-sensitive production system. Values altered in one part of the system are implicity rather than explicitly communicated and processed to and from the rule-based node. All communications to the rule-based node of common values changed by the nonrule-based nodes are by way of a list independent of and concurrently with any procedural request of the rule-based node, there being no necessary relation between the list contents and the procedural request.
摘要:
An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.
摘要:
A system is provided for generating transition effects for use on a visual display. The system includes a binary table for describing a transition effect and a method for ordering the rows in the table to produce the transition. The table includes an arbitrary number of rows, each row representing a cell (group of picture elements) on the display. A numerical value, based on any function of cell location, is associated with each cell. The table is then sorted according to the numerical values. Each row in the sorted table drives a step in the transition effect. The cells described by the various rows are changed in sorted order to display the material from the image being transitioned-to. The sequence of processing of the rows causes the desired transition effect. By varying the function used to order the rows, an infinite variety of transition effects can be created.
摘要:
An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time. It also provides improved pharmacokinetic parameters due to an extended and constant in vivo release including substantial decreased peak concentrations, despite increased bioavailability, substantial extended times for maximal concentration, and higher minimal concentrations when compared with conventional immediate release dosage forms and a recent modified release tacrolimus dosage form.
摘要:
The method of applying constraints across a generally extensible and configurable resource delivery system as a basis for identifying or calculating the relative impacts of each constraint on resource delivery to various points and, through the use of constraint release mechanisms, developing prescriptive courses of action to optimize and increase the certainty of delivery of the resource, or in the reverse sense, restrict delivery of the resource. In an embodiment of the present invention, a method for characterizing the availability and potential use of water resources alongside associated impacts in order to identify and time the various policy decisions and investments needed to ensure access to water supplies over time given multiple stakeholders and uncertain, variable supplies and demands where such embodiment provides additional methods generally applicable across the full scope of embodiments of the invention.