公开(公告)号：US5934103A

公开(公告)日：1999-08-10

申请号：US841437

申请日：1997-04-22

申请人： Robert E. Ryan ,  John D. Hulsmann ,  Ron G. Pirich ,  Eric H. Schnittger ,  Theodore W. Hilgeman

发明人： Robert E. Ryan ,  John D. Hulsmann ,  Ron G. Pirich ,  Eric H. Schnittger ,  Theodore W. Hilgeman

IPC分类号： A61K49/18 ,  F25J3/02 ,  F25J3/06 ,  G01R33/28 ,  F25J1/00

CPC分类号： G01R33/28 ,  A61K49/1815 ,  F25J3/0685 ,  F25J2205/20 ,  F25J2215/36 ,  G01R33/5601 ,  Y10S62/919 ,  Y10S62/925

摘要： Spin-polarized xenon gas is provided in medical-grade purity for use as a contrast medium in MRI studies by use of collision-induced transfer of spin energy to the xenon gas from laser-pumped spin-polarized Rb gas. The Rb gas is provided by thermally vaporizing solid Rb at low pressure in a container having an inside surface coated with a siliconizing agent and exposed to the Rb gas. The combined xenon and Rb gases are separated after transfer of the spin energy in order to provide a sufficient purity of the xenon gas by use of a cryogenic separation process. The Rb gas is removed from the xenon gas and is returned cryogenically to a solid stated to an acceptable level of purity for the xenon gas. The gas may be analyzed optically to measure the remaining Rb concentration.

摘要翻译： 旋转极化氙气以医学级纯度提供，用于MRI研究中的造影剂，通过使用碰撞诱导的自旋能量转移到来自激光泵浦的自旋极化Rb气体的氙气。 通过在具有涂覆有硅化剂的内表面并暴露于Rb气体的容器中将低压固体Rb热汽化来提供Rb气体。 在转移自旋能量之后分离出氙气和铑气体，以便通过使用低温分离方法提供足够的纯度的氙气。 将Rb气体从氙气中除去，并将其低温回收成为氙气的可接受的纯度水平。 可以光学分析气体以测量剩余的Rb浓度。