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公开(公告)号：US06706743B2
公开(公告)日：2004-03-16
申请号：US10379976
申请日：2003-03-05
IPC分类号： A61K314164
CPC分类号： C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/24 , C07D285/06 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The instant invention provides &bgr;3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, wherein Ar, R, R1, R2, R3, R4, R5, R6, R7, R8, X, and Y, are as defined herein. The invention further provides intermediates useful in the preparation of the compounds of Formula (I), to combinations of the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, with anti-obesity agents; to pharmaceutical compositions comprising the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, or pharmaceutical compositions comprising the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, and anti-obesity agents; and methods of treating &bgr;3 adrenergic receptor-mediated diseases, conditions, or disorders in a mammal which methods comprise administering to the mammal an effective amount of a compound of Formula (I), a stereoisomer or prodrug thereof, or a pharmaceutical composition thereof; or a combination of a compound of Formula (I), a pharmaceutically acceptable salt of the compound, stereoisomer, or prodrug, and an anti-obesity agent, or a pharmaceutical composition thereof.
摘要翻译： 本发明提供结构式（I）的β3肾上腺素能受体激动剂，其立体异构体和前药以及化合物，立体异构体和前药的药学上可接受的盐，其中Ar，R，R 1，R 2，R 3，R 4，R 5，R 6 ，R7，R8，X和Y如本文所定义。本发明还提供可用于制备式（I）化合物的中间体，式（I）化合物，其立体异构体和前药的组合， 和化合物，立体异构体和前药的药学上可接受的盐与抗肥胖剂; 包括式（I）化合物，其立体异构体和前药以及化合物，立体异构体和前药的药学上可接受的盐或包含式（I）化合物的药物组合物，其立体异构体和前药以及 化合物的药学上可接受的盐，立体异构体和前药以及抗肥胖剂; 以及治疗哺乳动物中β3肾上腺素能受体介导的疾病，病症或病症的方法，所述方法包括向哺乳动物施用有效量的式（I）化合物，其立体异构体或前药或其药物组合物; 或式（I）的化合物，化合物的药学上可接受的盐，立体异构体或前药，和抗肥胖剂或其药物组合物的组合。
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公开(公告)号：US06566377B2
公开(公告)日：2003-05-20
申请号：US09981551
申请日：2001-10-17
IPC分类号： A61K314439
CPC分类号： C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/24 , C07D285/06 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The instant invention provides &bgr;3 adrenergic receptor agonists of structural Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, wherein Ar, R, R1, R2, R3, R4, R5, R6, R7, R8, X, and Y, are as defined herein. The invention further provides intermediates useful in the preparation of the compounds of Formula (I), to combinations of the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, with anti-obesity agents; to pharmaceutical compositions comprising the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, or pharmaceutical compositions comprising the compounds of Formula (I), the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers and prodrugs, and anti-obesity agents; and methods of treating &bgr;3 adrenergic receptor-mediated diseases, conditions, or disorders in a mammal which methods comprise administering to the mammal an effective amount of a compound of Formula (I), a stereoisomer or prodrug thereof, or a pharmaceutical composition thereof; or a combination of a compound of Formula (I), a pharmaceutically acceptable salt of the compound, stereoisomer, or prodrug, and an anti-obesity agent, or a pharmaceutical composition thereof.
摘要翻译： 本发明提供结构式（I）的β3肾上腺素能受体激动剂，其立体异构体和前药以及化合物，立体异构体和前药的药学上可接受的盐，其中Ar，R，R 1，R 2，R 3，R 4，R 5，R 6 ，R7，R8，X和Y如本文所定义。 本发明还提供可用于制备式（I）化合物的中间体，式（I）化合物，其立体异构体和前药以及化合物，立体异构体和前药的药学上可接受的盐与抗体的组合， - 肥胖剂; 包括式（I）的化合物，其立体异构体和前药以及化合物，立体异构体和前药的药学上可接受的盐或包含式（I）化合物的药物组合物，其立体异构体和前药以及 化合物的药学上可接受的盐，立体异构体和前药以及抗肥胖剂; 以及治疗哺乳动物中β3肾上腺素能受体介导的疾病，病症或病症的方法，所述方法包括向哺乳动物施用有效量的式（I）化合物，其立体异构体或前药或其药物组合物; 或式（I）的化合物，化合物的药学上可接受的盐，立体异构体或前药的组合，和抗肥胖剂或其药物组合物。
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公开(公告)号：US20100228702A1
公开(公告)日：2010-09-09
申请号：US12785178
申请日：2010-05-21
申请人： Christopher S. Davis , David R. Johnson , Robert F. Day , Stephan Hoefnagels , Timothy P. McKee
发明人： Christopher S. Davis , David R. Johnson , Robert F. Day , Stephan Hoefnagels , Timothy P. McKee
IPC分类号： G06F17/30
CPC分类号： G06F17/30067 , G06F17/30115 , G06F17/30123 , G06F17/30176
摘要： A file operations engine is provided that manages many user interactions with their files via a computer system. The operation engine may provide a user with the option to keep both files that have a file name conflict. It may further permit the user to rename a file involved with a file name conflict. The operations engine may also automatically rename one of the files of a file name conflict by appending a character to a root of the filename. The character may include the lowest integer available for the root in a destination for the files. The operations engine may provide the option to keep both files as part of a pre-calculation of potential errors for a requested operation. The operations engine may place file name conflicts in an error queue and permit the user to select an option to keep both files after the conflict is encountered.
摘要翻译： 提供了一种文件操作引擎，通过计算机系统管理与他们的文件的许多用户交互。 操作引擎可以向用户提供保持具有文件名冲突的两个文件的选项。 它还可以允许用户重命名涉及文件名冲突的文件。 操作引擎还可以通过将文件附加到文件名的根来自动重命名文件名冲突的一个文件。 字符可能包括可用于文件目标中根目录的最小整数。 操作引擎可以提供将两个文件作为对所请求操作的潜在错误的预先计算的一部分的选项。 操作引擎可能会将文件名冲突置于错误队列中，并允许用户选择一个选项以在遇到冲突后保留这两个文件。
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公开(公告)号：US07624307B2
公开(公告)日：2009-11-24
申请号：US11136512
申请日：2005-05-25
申请人： Christopher S. Davis , David R. Johnson , Robert F. Day , Stephan Hoefnagels , Timothy P. McKee
发明人： Christopher S. Davis , David R. Johnson , Robert F. Day , Stephan Hoefnagels , Timothy P. McKee
IPC分类号： G06F11/00
CPC分类号： G06F3/0486 , G06F3/04895
摘要： A file operations engine is provided that manages many user interactions with their files via a computer system. The operation engine may place certain classes of errors in an error queue while performing a requested operation without waiting for a user to satisfy the errors prior to continuing with the operation. In addition, the operations engine may pre-calculate potential errors for a requested operation prior to performing the operation. Dialogs may be provided to a user to satisfy errors listed in an error queue and/or identified while pre-calculating potential errors. Methods are provided for handling file operations errors and for interacting with a user interface for file operations. Computer-executable instructions for implementing the disclosed methods are stored on computer-readable media.
摘要翻译： 提供了一种文件操作引擎，通过计算机系统管理与他们的文件的许多用户交互。 操作引擎可以在执行所请求的操作的同时在错误队列中放置某些类别的错误，而不等待用户在继续操作之前满足错误。 此外，操作引擎可以在执行操作之前预先计算所请求操作的潜在错误。 可以向用户提供对话以满足错误队列中列出的错误和/或在预先计算潜在错误的情况下识别。 提供了处理文件操作错误以及与用户界面进行文件操作交互的方法。 用于实现所公开的方法的计算机可执行指令被存储在计算机可读介质上。
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公开(公告)号：US5574854A
公开(公告)日：1996-11-12
申请号：US406641
申请日：1995-03-16
申请人： Russell P. Blake , Robert F. Day
发明人： Russell P. Blake , Robert F. Day
CPC分类号： G06F11/3688
摘要： A simulation system to simulate the execution of a computer program. The computer program is developed for invoking operating system functions of a first operating system. Each operating system function performs a behavior in accordance with passed parameters. The simulation system generates a log during the execution of the computer program under control of the first operating system. The log includes an indication of each invocation of an operating system function by the computer program and an indication of each parameter passed to the operating system function by the computer program and the current time. The logged execution is then simulated by the simulation system on a second operating system. The simulation system invokes an operating system function of the second operating system to perform a behavior similar to the behavior performed by each logged invocation of the operating system function of the first operating system in accordance with the passed parameters. Comparison of the functionality, reliability, and performance of the two systems are thereby enabled.
摘要翻译： 用于模拟计算机程序执行的仿真系统。 该计算机程序被开发用于调用第一操作系统的操作系统功能。 每个操作系统功能根据传递的参数执行一个行为。 仿真系统在第一操作系统的控制下在执行计算机程序期间生成日志。 日志包括计算机程序对操作系统功能的每次调用的指示以及由计算机程序和当前时间传递给操作系统功能的每个参数的指示。 然后由第二操作系统上的模拟系统模拟记录的执行。 仿真系统调用第二操作系统的操作系统功能，以执行类似于根据所传递的参数对第一操作系统的操作系统功能的每次记录调用执行的行为的行为。 由此实现了两个系统的功能，可靠性和性能的比较。
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6.发明授权Integrated email and chat archiving with fine grained user control for chat archiving 有权集成电子邮件和聊天归档，具有细粒度的用户控制，可进行聊天归档公开(公告)号：US08583741B2
公开(公告)日：2013-11-12
申请号：US11348578
申请日：2006-02-06
IPC分类号： G06F15/16
CPC分类号： G06Q10/107 , H04L12/1831
摘要： Participants in a chat session can control the archiving of chat messages in the chat session. Participants in a chat session send and receive a first set of chat messages, which are archived. A command to deactivate archiving is made by one of the participants. Messages in the chat session that are sent and received subsequent to the command to deactivate archiving are not archived. Archiving may be reactivated and messages subsequent to the command to reactivate archiving are archived.
摘要翻译： 聊天会话中的参与者可以在聊天会话中控制聊天消息的归档。 聊天会话中的参与者发送和接收第一组聊天消息，这些聊天消息被归档。 其中一个参与者进行停用归档命令。 在关闭停用命令的命令后发送和接收的聊天会话中的消息不会归档。 存档可能会被重新启动，命令之后的邮件将重新启动归档归档。
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公开(公告)号：US08290997B2
公开(公告)日：2012-10-16
申请号：US12956512
申请日：2010-11-30
申请人： Christopher S. Davis , David R. Johnson , Robert F. Day , Stephan Hoefnagels , Timothy P. McKee
发明人： Christopher S. Davis , David R. Johnson , Robert F. Day , Stephan Hoefnagels , Timothy P. McKee
IPC分类号： G06F17/30
CPC分类号： G06F17/30067 , G06F17/30115 , G06F17/30123 , G06F17/30176
摘要： A file operations engine is provided that manages many user interactions with their files via a computer system. The operation engine may provide a user with the option to keep both files that have a file name conflict. It may further permit the user to rename a file involved with a file name conflict. The operations engine may also automatically rename one of the files of a file name conflict by appending a character to a root of the filename. The character may include the lowest integer available for the root in a destination for the files. The operations engine may provide the option to keep both files as part of a pre-calculation of potential errors for a requested operation. The operations engine may place file name conflicts in an error queue and permit the user to select an option to keep both files after the conflict is encountered.
摘要翻译： 提供了一种文件操作引擎，通过计算机系统管理与他们的文件的许多用户交互。 操作引擎可以向用户提供保持具有文件名冲突的两个文件的选项。 它还可以允许用户重命名涉及文件名冲突的文件。 操作引擎还可以通过将文件附加到文件名的根来自动重命名文件名冲突的一个文件。 字符可能包括可用于文件目标中根目录的最小整数。 操作引擎可以提供将两个文件作为对所请求操作的潜在错误的预先计算的一部分的选项。 操作引擎可能会将文件名冲突置于错误队列中，并允许用户选择一个选项以在遇到冲突后保留这两个文件。
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8.发明授权System and method having programmable containers with functionality for managing objects 失效具有可编程容器的系统和方法具有管理对象的功能
公开(公告)号：US5682532A
公开(公告)日：1997-10-28
申请号：US237357
申请日：1994-05-02
申请人： Darren B. Remington , Brian T. Fleming , David E. McCauley, III , Jan T. Miksovsky , John M. Tippett , Scott R. Ludwig , Robert F. Day
发明人： Darren B. Remington , Brian T. Fleming , David E. McCauley, III , Jan T. Miksovsky , John M. Tippett , Scott R. Ludwig , Robert F. Day
CPC分类号： G06F9/543 , G06F9/4428 , G06F9/4435
摘要： An improved storage mechanism is provided. In a preferred embodiment of the present invention, a container is used for storing objects, links to objects, and other containers. The container of the preferred embodiment is programmable so that the methods of the container are replaceable and the functionality of the container is extendible through the use of a command unit.
摘要翻译： 提供了改进的存储机制。 在本发明的优选实施例中，容器用于存储物体，到物体的链接和其他容器。 优选实施例的容器是可编程的，使得容器的方法是可替换的，并且通过使用命令单元可以扩展容器的功能。
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公开(公告)号：US09443105B2
公开(公告)日：2016-09-13
申请号：US13442507
申请日：2012-04-09
CPC分类号： G06F21/6218 , G06F3/0482 , G06F3/04847 , G06F17/3056 , G06F21/62 , G06F21/629
摘要： A system, method, and computer-accessible medium for protecting user choice settings are provided. The system and method provide an application programming interface that uses a security subsystem to unlock, write, and relock the user choice settings to insure that the user's choices are enforced and respected by the applications that attempt to change them in a manner that is verifiable and transparent to the user. The user is notified whenever a change to their user choice settings is made.
摘要翻译： 提供了一种用于保护用户选择设置的系统，方法和计算机可访问介质。 该系统和方法提供了一种应用程序编程接口，该接口使用安全子系统来解锁，写入和重新锁定用户选择设置，以确保用户的选择得到强制执行并被试图以可验证的方式更改的应用程序所尊重， 对用户透明。 每当对用户选择设置进行更改时，都会通知用户。
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公开(公告)号：US08134407B2
公开(公告)日：2012-03-13
申请号：US12625870
申请日：2009-11-25
申请人： Scott A. Wurcer , Robert F. Day
发明人： Scott A. Wurcer , Robert F. Day
IPC分类号： H03F3/45
CPC分类号： H03F3/45183 , H03F3/3069 , H03F3/45475 , H03F2200/513 , H03F2203/45318 , H03F2203/45366
摘要： In an embodiment of the invention, a differential input signal is coupled to a plurality of transconductance blocks. In some embodiments, each of the transconductance blocks divide an input transconductance among a plurality of signal paths to a plurality of outputs in each transconductance block. In an embodiment, the input transconductance may be divided based a ratio of transistor areas in the plurality of signal paths, though other embodiments may divide the transconductance differently. In some embodiments, transconductance block outputs of a plurality of transconductance blocks may be cross-coupled to provide a gain path for a differential signal than is greater than that of a common mode signal.
摘要翻译： 在本发明的实施例中，差分输入信号耦合到多个跨导块。 在一些实施例中，每个跨导块将多个信号路径之间的输入跨导划分成每个跨导块中的多个输出。 在一个实施例中，可以基于多个信号路径中的晶体管区域的比例来分配输入跨导，尽管其他实施例可以不同地划分跨导。 在一些实施例中，多个跨导块的跨导块输出可以被交叉耦合以提供差于比共模信号的增益路径的差分信号的增益路径。
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