公开(公告)号：US20050053967A1

公开(公告)日：2005-03-10

申请号：US10800322

申请日：2004-03-12

申请人： Robert James ,  Julianne Henry ,  Jan Kazenwadel ,  Nick Pellekaan ,  Anne MacPherson ,  Susan O'Connor

发明人： Robert James ,  Julianne Henry ,  Jan Kazenwadel ,  Nick Pellekaan ,  Anne MacPherson ,  Susan O'Connor

IPC分类号： C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates generally to novel nucleic acid molecules, the levels and/or patterns of expression of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm and to derivatives, homologues or analogues of said molecules. More particularly, the present invention is directed to novel nucleic acid molecules, the levels of expression of which are indicative of the onset and/or progression of a gastrointestinal tract neoplasm, such as an adenoma, and to derivatives, homologues or analogues of said molecules. The present invention is further directed to isolated proteins encoded thereby and to derivatives, homologues, analogues, chemical equivalents and mimetics thereof. The molecules of the present invention are useful in a range of prophylactic, therapeutic and/or diagnostic applications including, but not limited to, those relating to the diagnosis and/or treatment of colorectal neoplasms such as colorectal adenomas. In a related aspect, the present invention is directed to a method of screening a subject for the onset, predisposition to the onset and/or progression of a neoplasm by screening for modulation in the level of expression of one or more nucleic acid molecule markers.

摘要翻译： 本发明一般涉及新的核酸分子，其表达的水平和/或模式指示肿瘤和所述分子的衍生物，同系物或类似物的起始和/或进展的倾向。 更具体地，本发明涉及新的核酸分子，其表达水平表示胃肠道肿瘤如腺瘤的发作和/或进展，以及所述分子的衍生物，同系物或类似物 。 本发明还涉及由其编码的分离的蛋白质及其衍生物，同系物，类似物，化学等价物和其模拟物。 本发明的分子可用于一系列预防，治疗和/或诊断应用，包括但不限于与结肠直肠肿瘤如结肠直肠腺瘤的诊断和/或治疗相关的那些应用。 在相关方面，本发明涉及通过筛选一种或多种核酸分子标记物的表达水平的调节来筛选受试者对于肿瘤发病和/或进展的易感性的方法。