公开(公告)号：US08999323B2

公开(公告)日：2015-04-07

申请号：US12744412

申请日：2008-11-21

申请人： Robert Liska ,  Jürgen Stampfl ,  Franz Varga ,  Heinrich Gruber ,  Stefan Baudis ,  Christian Heller ,  Monika Schuster ,  Helga Bergmeister ,  Günter Weigel ,  Claudia Dworak

发明人： Robert Liska ,  Jürgen Stampfl ,  Franz Varga ,  Heinrich Gruber ,  Stefan Baudis ,  Christian Heller ,  Monika Schuster ,  Helga Bergmeister ,  Günter Weigel ,  Claudia Dworak

IPC分类号： A61K39/395 ,  A61K38/16 ,  C07C271/10 ,  C07C271/20 ,  C07C271/22 ,  C07C69/96 ,  C07F9/113 ,  C07F9/40 ,  C08F2/46 ,  A61L27/56

CPC分类号： A61L27/56

摘要： The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ≧2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ═O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ═O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a) polymerization initiator(s); and 0 to 95% by weight of solvent(s).

摘要翻译： 本发明涉及一种用于制备基于聚乙烯醇的可生物降解的生物相容性交联聚合物的聚合可固化组合物，其包含：5至100重量％的（a）乙烯基酯单体之一 通式（I）至（III）：其中X为氧，硫，氮或磷; n为1〜1000，n的至少20％为≥2; R1选自氢; 具有1至30个碳原子的直链，支链或环状，饱和或不饱和的n价烃基，其任选地具有杂原子并且任选地被一个或多个选自-OH，-COON，-CN，-CHO和 可生物降解的生物相容性低聚物和聚合物的n价基团; m为1〜5的整数; R2选自氢，-OH，ΟO和R1中列出的选项; 并且R3选自氢，-OH和R1中列出的选项; 0至50重量％的烯属不饱和共聚单体; 0〜10重量％的（a）聚合引发剂; 和0至95重量％的溶剂。

公开(公告)号：US20100303804A1

公开(公告)日：2010-12-02

申请号：US12744412

申请日：2008-11-21

申请人： Robert Liska ,  Jürgen Stampfl ,  Franz Varga ,  Heinrich Gruber ,  Stefan Baudis ,  Christian Heller ,  Monika Schuster ,  Helga Bergmeister ,  Günter Weigel ,  Claudia Dworak

发明人： Robert Liska ,  Jürgen Stampfl ,  Franz Varga ,  Heinrich Gruber ,  Stefan Baudis ,  Christian Heller ,  Monika Schuster ,  Helga Bergmeister ,  Günter Weigel ,  Claudia Dworak

IPC分类号： A61K39/395 ,  C07C69/96 ,  C07C271/20 ,  C07C271/22 ,  C07C271/10 ,  C07F9/40 ,  C07F9/113 ,  C08F2/46 ,  A61K38/16

CPC分类号： A61L27/56

摘要： The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ≧2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ═O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ═O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a) polymerization initiator(s); and 0 to 95% by weight of solvent(s).

摘要翻译： 本发明涉及一种用于制备基于聚乙烯醇的可生物降解的生物相容性交联聚合物的聚合可固化组合物，其包含：5至100重量％的（a）乙烯基酯单体之一 通式（I）至（III）：其中X为氧，硫，氮或磷; n为1〜1000，n的至少20％为≥2; R1选自氢; 具有1至30个碳原子的直链，支链或环状，饱和或不饱和的n价烃基，其任选地具有杂原子并且任选地被一个或多个选自-OH，-COON，-CN，-CHO和 可生物降解的生物相容性低聚物和聚合物的n价基团; m为1〜5的整数; R2选自氢，-OH，ΟO和R1中列出的选项; 并且R3选自氢，-OH和R1中列出的选项; 0至50重量％的烯属不饱和共聚单体; 0〜10重量％的（a）聚合引发剂; 和0至95重量％的溶剂。