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    Methods for the production of polymer carrier materials based on carbon hydrate-bis(meth)acryl-amides
    1.
    发明授权
    Methods for the production of polymer carrier materials based on carbon hydrate-bis(meth)acryl-amides 失效
    基于碳水化合物 - 双（甲基）丙烯酰胺的聚合物载体材料的生产方法

    公开(公告)号：US07674839B2

    公开(公告)日：2010-03-09

    申请号：US11631236

    申请日：2005-06-24

    Applicant: Thomas Verdianz ,  Heinrich Gruber ,  Simone Knaus ,  Alexander Poschalko

    Inventor： Thomas Verdianz ,  Heinrich Gruber ,  Simone Knaus ,  Alexander Poschalko

    IPC: C08F236/20 ,  C07H15/04 ,  C07H15/12 ,  C08J9/00 ,  C08F251/00

    CPC classification number: C08F222/385 ,  B01D15/3804 ,  B01J20/26 ,  B01J20/261 ,  B01J20/285 ,  B01J20/321

    Abstract: The invention relates to methods for the production of polymer carrier materials for solid phase synthesis, particularly for peptide synthesis. (Meth)acrylamide derivatives based on carbon hydrates, which can also contain other protective groups, are polymerized by means of suspension polymerization in an aqueous phase, optionally with the addition of pore-forming additives, and subsequently the protective groups are fully or partially cleaved. It is thus possible to obtain polymer carriers whose morphology (particle size, porosity), degree of cross-linking and swelling capability in aqueous and organic media can be adjusted in a targeted manner and whose reactive groups offer multiple opportunities for the immobilization of anchor groups and protective groups. The hydroxyl groups of the polymer carrier can be activated according to usual methods of solid phase synthesis.

    Abstract translation: 本发明涉及用于制备用于固相合成的聚合物载体材料的方法，特别是用于肽合成。 基于碳水合物（也可以含有其它保护基团）的（甲基）丙烯酰胺衍生物通过悬浮聚合在水相中聚合，任选地加入成孔添加剂，随后保护基团被完全或部分切割 。 因此，可以获得聚合物载体，其在水和有机介质中的形态（颗粒尺寸，孔隙率），交联度和溶胀能力可以以目标方式调节，并且其反应性基团为固定基团提供多个机会 和保护组。 聚合物载体的羟基可以根据固相合成的常规方法活化。

    Methods for the Production of Polymer Carrier Materials Based on Carbon Hydrate-Bis(Meth)Acryl-Amides
    2.
    发明申请
    Methods for the Production of Polymer Carrier Materials Based on Carbon Hydrate-Bis(Meth)Acryl-Amides 失效
    基于碳水化合物 - 双（甲基）丙烯酰胺的聚合物载体材料的制备方法

    公开(公告)号：US20080300383A1

    公开(公告)日：2008-12-04

    申请号：US11631236

    申请日：2005-06-24

    Applicant: Thomas Verdianz ,  Heinrich Gruber ,  Simone Knaus ,  Alexander Poschalko

    Inventor： Thomas Verdianz ,  Heinrich Gruber ,  Simone Knaus ,  Alexander Poschalko

    IPC: C07K1/04 ,  C08F20/58

    CPC classification number: C08F222/385 ,  B01D15/3804 ,  B01J20/26 ,  B01J20/261 ,  B01J20/285 ,  B01J20/321

    Abstract: The invention relates to methods for the production of polymer carrier materials for solid phase synthesis, particularly for peptide synthesis. (Meth)acrylamide derivatives based on carbon hydrates, which can also contain other protective groups, are polymerized by means of suspension polymerization in an aqueous phase, optionally with the addition of pore-forming additives, and subsequently the protective groups are fully or partially cleaved. It is thus possible to obtain polymer carriers whose morphology (particle size, porosity), degree of cross-linking and swelling capability in aqueous and organic media can be adjusted in a targeted manner and whose reactive groups offer multiple opportunities for the immobilization of anchor groups and protective groups. The hydroxyl groups of the polymer carrier can be activated according to usual methods of solid phase synthesis.

    Abstract translation: 本发明涉及用于制备用于固相合成的聚合物载体材料的方法，特别是用于肽合成。 基于碳水合物（也可以含有其它保护基团）的（甲基）丙烯酰胺衍生物通过悬浮聚合在水相中聚合，任选地加入成孔添加剂，随后保护基团被完全或部分切割 。 因此，可以获得聚合物载体，其在水和有机介质中的形态（颗粒尺寸，孔隙率），交联度和溶胀能力可以以目标方式调节，并且其反应性基团为固定基团提供多个机会 和保护组。 聚合物载体的羟基可以根据固相合成的常规方法活化。

    Heat-stable polyimides and polyamide-imides with modified benzhydrol structural elements and their preparation
    4.
    发明授权
    Heat-stable polyimides and polyamide-imides with modified benzhydrol structural elements and their preparation 失效
    具有改性二苯基甲醛结构单元的热稳定聚酰亚胺和聚酰胺 - 酰亚胺及其制备方法

    公开(公告)号：US5378799A

    公开(公告)日：1995-01-03

    申请号：US119650

    申请日：1993-09-13

    Applicant: Gerhard Greber, deceased ,  Heinrich Gruber ,  Marcel Sychra

    Inventor： Gerhard Greber, deceased ,  Heinrich Gruber ,  Marcel Sychra

    IPC: C08G73/10 ,  C08G73/14 ,  C08G69/26

    CPC classification number: C08G73/1053 ,  C08G73/10 ,  C08G73/1064 ,  C08G73/14

    Abstract: Heat-stable polyimides and polyamideimides with modified benzhydrol structural elements and a process of preparing thereof; wherein the polyimides and polyamideimides are obtained by reacting 3,3'4,4'-benzhydroltetracarboxylic acid dimethyl ester a) with only a diamine and then cyclized to give polyimides or b) with a diamine and with trimellitic, phthalic-or isophthalic acid (or the anhydrides, acid chlorides, anhydride chlorides or esters) and is then cyclized to give polyamideimides.

    Abstract translation: 具有改性二苯基甲醛结构元素的热稳定性聚酰亚胺和聚酰亚胺及其制备方法; 其中所述聚酰亚胺和聚酰胺酰亚胺通过使3,3'4,4'-二苯甲醇四羧酸二甲酯a）与仅二胺反应获得，然后环化以得到聚酰亚胺或b）与二胺和偏苯三酸，邻苯二甲酸或间苯二甲酸 或酸酐，酰氯，酸酐氯化物或酯），然后环化得到聚酰胺酰亚胺。

    Soluble and/or fusible polyimides and polyamidoimides
    6.
    发明授权
    Soluble and/or fusible polyimides and polyamidoimides 失效
    可溶性和/或可熔性聚酰亚胺和聚亚烷基二胺

    公开(公告)号：US5164476A

    公开(公告)日：1992-11-17

    申请号：US466433

    申请日：1990-06-12

    Applicant: Gerd Greber ,  Heinrich Gruber ,  Marcel Sychra

    Inventor： Gerd Greber ,  Heinrich Gruber ,  Marcel Sychra

    IPC: C08G73/10 ,  C08G73/14

    CPC classification number: C08G73/1064 ,  C08G73/14

    Abstract: Soluble and/or fusible polyimides or polyamidoimides of the general formula I ##STR1## in which R denotes a divalent radical of the formula II ##STR2## Ar denotes trivalent or tetravalent aromatic radicals or mixtures thereof, X denotes the amide radical, if Ar is trivalent, and if Ar is tetravalent denotes the imide radical and R.sub.1 denotes divalent aromatic radicals, and a process for their preparation.

    Abstract translation: PCT No.PCT / EP88 / 01019 Sec。 371 1990年6月12日第 102（e）日期1990年6月12日PCT提交1988年11月10日PCT公布。 出版物WO89 / 04336 日期：1989年5月18日。通式I的不溶性和/或可熔性聚酰亚胺或聚酰胺酰亚胺其中R表示式II的二价基团.Ar表示三价或四价芳族基团或其混合物，X 表示酰胺基，如果Ar是三价的，并且如果Ar是四价，则表示酰亚胺基，R 1表示二价芳族基团，以及它们的制备方法。

    Sulfur-containing aromatic tetracarboxylic acids and derivatives thereof
    7.
    发明授权
    Sulfur-containing aromatic tetracarboxylic acids and derivatives thereof 失效
    含硫的芳族四羧酸及其衍生物

    公开(公告)号：US5126462A

    公开(公告)日：1992-06-30

    申请号：US466435

    申请日：1990-06-12

    Applicant: Gerd Greber ,  Heinrich Gruber ,  Marcel Sychra

    Inventor： Gerd Greber ,  Heinrich Gruber ,  Marcel Sychra

    IPC: C07D209/48 ,  C07C317/14 ,  C07C323/65 ,  C07D209/49 ,  C07D307/89 ,  C07D487/04 ,  C08G73/10

    CPC classification number: C07C323/65 ,  C07D307/89

    Abstract: Aromatic tetracarboxylic acids or derivatives thereof of the general formula I ##STR1## in which R denotes a divalent radical of the formula II ##STR2## Ar denotes tri- or tetravalent aromatic radicals or mixtures thereof, X, if Ar is trivalent, denotes an amide radical, and if Ar is tetravalent denotes an imide radical, and Y and Z either together denote the anhydride radical --CO--O--CO-- or by themselves and independently of one another denote the radicals --COOH, --COCL or --COOR.sub.1, and a process for their preparation.

    Abstract translation: PCT No.PCT / EP88 / 01017 Sec。 371 1990年6月12日第 102（e）日期1990年6月12日PCT提交1988年11月10日PCT公布。 出版物WO89 / 04298 日本1989年5月18日。通式I的芳族四羧酸或其衍生物，其中R表示式II的二价基团.Ar表示三价或四价芳族基团或其混合物，X， 如果Ar为三价，则表示酰胺基，如果Ar为四价，则表示酰亚胺基，Y和Z一起表示酸酐基-CO-O-CO-或彼此独立地表示基团-COOH ，-COCL或-COOR1，及其制备方法。

    Polymerizable compositions with acylgermanium compounds
    9.
    发明授权
    Polymerizable compositions with acylgermanium compounds 有权
    具有酰基锗化合物的可聚合组合物

    公开(公告)号：US07605190B2

    公开(公告)日：2009-10-20

    申请号：US11902865

    申请日：2007-09-26

    Applicant: Norbert Moszner ,  Ulrich Salz ,  Urs Karl Fischer ,  Robert Liska ,  Heinrich Gruber ,  Beate Ganster

    Inventor： Norbert Moszner ,  Ulrich Salz ,  Urs Karl Fischer ,  Robert Liska ,  Heinrich Gruber ,  Beate Ganster

    IPC: A61C13/00 ,  A61C13/225 ,  A61K6/00 ,  C08F2/50 ,  C08J3/28

    CPC classification number: C08F2/50 ,  A61K6/083 ,  C08F4/72 ,  Y10S522/908 ,  C08L33/00

    Abstract: Composition with at least one polymerizable binder and at least one polymerization initiator, which contains at least one acylgermanium compound according to general Formula (I), in which R0 is a substituted or unsubstituted C1-18-alkyl radical or an acyl group; R1 and R2 are H, an acyl group or have one of the meanings given for R3; R3 is a branched or linear C1-18-alkyl radical which can be unsubstituted or substituted one or more times by —O—, —NH—, —NR—, —S— or interrupted by other groups, trimethylsilyl, hal-(CH3)2Si—[OSi(CH3)2]r−, (CH3)3Si—[OSi(CH3)2]r—, —COOH, —COO—R10, —CO—NR11R12, —CO-vinyl, —CO-phenyl, phenyl-C1-4-alkyl, phenyl, naphthyl or biphenyl, C5-12 cycloalkyl, a 5 or 6-membered O, S or N-containing heterocyclic ring, halogen, OH, an aromatic C6-30 radical which can be substituted or unsubstituted and/or interrupted by O, S or —NR—, or a branched, cyclic or linear C1-20 alkyl, -alkenyl, -alkoxy or -alkenoxy radical; m is 1, 2 or 3; n is 0 or 1 and p is 0 or 1; wherein in each case two of the radicals R0, R1, R2 or R3 can be connected to each other accompanied by the formulation of a 5 to 8 member ring; and the use of acylegermanium compounds of Formula (I), for example, as initiator for radical polymerization.

    Abstract translation: 含有至少一种可聚合粘合剂和至少一种聚合引发剂的组合物，其含有至少一种根据通式（I）的酰基锗化合物，其中R 0是取代或未取代的C 1-18 - 烷基或酰基; R 1和R 2是H，酰基或具有R 3给出的含义之一; R3是支链或直链的C1-18 - 烷基，其可以是未取代的或被-O - ， - NH - ， - NR - ， - S-取代或被其它基团间隔的一个或多个，三甲基甲硅烷基，hal-（CH 3 ）2Si- [OSi（CH 3）2] r - ，（CH 3）3 Si- [OSi（CH 3）2] r - ，-COOH，-COO-R 10，-CO-NR 11 R 12，-CO-乙烯基， 苯基，C 1-4 - 烷基，苯基，萘基或联苯基，C 5-12环烷基，5或6元O，S或N的杂环，卤素，OH，可被取代的芳族C 6-30基团 或未取代和/或被O，S或-NR-或支链，环状或直链的C 1-20烷基， - 烯基， - 烷氧基或 - m为1,2或3; n为0或1，p为0或1; 其中在每种情况下，基团R 0，R 1，R 2或R 3中的两个可以相互连接，伴随着5-8元环的配制; 以及使用式（I）的乙烯基锗化合物，例如作为自由基聚合的引发剂。

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