公开(公告)号：US6068644A

公开(公告)日：2000-05-30

申请号：US257742

申请日：1999-02-24

申请人： Robert Lulo ,  Susana Martinez ,  Ernesto Avellanet

发明人： Robert Lulo ,  Susana Martinez ,  Ernesto Avellanet

IPC分类号： A61B17/00 ,  A61B17/12 ,  A61M25/088 ,  A61M29/00

CPC分类号： A61B17/1214 ,  A61B17/12022 ,  A61B2017/00539 ,  A61B2017/12081

摘要： A medical device for placing an embolic coil at a preselected location within a vessel comprising a positioning catheter having a distal tip for retaining the embolic coil which when pressurized with a fluid expands outwardly to release the coil at the preselected position. The positioning catheter includes a coaxial stiffening tube and helically wound coil transition zone to provide improved positioning of the embolic coil.

摘要翻译： 一种用于将栓塞线圈放置在容器内的预选位置处的医疗装置，包括具有用于保持栓塞线圈的远侧末端的定位导管，其在用流体加压时向外膨胀以将线圈释放到预选位置。 定位导管包括同轴加强管和螺旋缠绕的线圈过渡区，以提供改善的栓塞线圈的定位。

公开(公告)号：US5002875A

公开(公告)日：1991-03-26

申请号：US90623

申请日：1987-08-28

申请人： Sanford A. Lacks ,  Susana Martinez ,  Paloma Lopez ,  Manuel Espinosa

发明人： Sanford A. Lacks ,  Susana Martinez ,  Paloma Lopez ,  Manuel Espinosa

IPC分类号： C12N9/12

CPC分类号： C12N9/1252

摘要： A method is disclosed for cloning the gene which encodes a DNA polymerase-exonuclease of Streptococcus pneumoniae. Plasmid pSM22, the vector containing the pneumocccal polA gene, facilitates the expression of 50-fold greater amounts of the PolI enzyme.

摘要翻译： 公开了克隆编码肺炎链球菌的DNA聚合酶 - 外切核酸酶的基因的方法。 含有肺炎球菌polA基因的载体质粒pSM22有助于表达50倍以上PolI酶的量。

公开(公告)号：US06245040B1

公开(公告)日：2001-06-12

申请号：US08705005

申请日：1996-08-29

申请人： Mark Inderbitzen ,  Kirk Johnson ,  Susana Martinez

发明人： Mark Inderbitzen ,  Kirk Johnson ,  Susana Martinez

IPC分类号： A61M2900

CPC分类号： A61M25/104 ,  A61M2025/1047 ,  A61M2025/1059 ,  A61M2025/1084 ,  A61M2025/1095

摘要： A dilation catheter suitable for use in medical procedures is provided which includes a balloon disposed on an elongated flexible tube. The tube is capable of passing fluid between the balloon and the tube for varying the balloon between a collapsed and expanded condition. The catheter includes a brace fitted over the balloon for restricting expansion of a selected portion of the balloon for forming a perfusion channel that allows fluid to be perfused past the balloon when it is expanded in a body vessel. A medical procedure for dilation under perfusion conditions is also provided.

摘要翻译： 提供了适用于医疗程序的扩张导管，其包括设置在细长柔性管上的气囊。 管能够在球囊和管之间传递流体，以在收缩和膨胀状态之间改变气球。 导管包括装配在气囊上的支架，用于限制球囊的选定部分的膨胀，以形成灌注通道，当灌注通道在体腔中膨胀时，允许流体通过气囊灌注。 还提供了在灌注条件下扩张的医疗手术。

公开(公告)号：US5484411A

公开(公告)日：1996-01-16

申请号：US182729

申请日：1994-01-14

申请人： Mark Inderbitzen ,  Susana Martinez

发明人： Mark Inderbitzen ,  Susana Martinez

IPC分类号： A61F2/958 ,  A61M29/02 ,  A61M29/00

CPC分类号： A61M25/104 ,  A61M25/1002 ,  A61M2025/1084 ,  A61M2025/1097

摘要： A dilation catheter suitable for use in medical procedures is provided. The catheter includes a balloon disposed on an elongated tube. The tube is capable of passing fluid between the balloon and the tube for varying the balloon between an inflated expanded condition and a deflated collapsed condition. The balloon includes a longitudinally extending spiral wall which forms a longitudinally extending spiral channel spaced inwardly from the exterior surface of the balloon when the balloon is in its expanded condition to allow fluid to be perfused past the balloon.

摘要翻译： 提供适用于医疗程序的扩张导管。 导管包括设置在细长管上的气囊。 管能够在气球和管之间传递流体，以在膨胀的膨胀状态和放气的收缩状态之间改变气球。 气球包括纵向延伸的螺旋壁，当气囊处于其膨胀状态时，形成一个从球囊的外表面向内间隔开的纵向延伸的螺旋通道，以允许流体通过球囊灌注。

公开(公告)号：US06613074B1

公开(公告)日：2003-09-02

申请号：US09518398

申请日：2000-03-03

申请人： Vladimir Mitelberg ,  Susana Martinez

发明人： Vladimir Mitelberg ,  Susana Martinez

IPC分类号： A61F206

CPC分类号： A61B17/12022 ,  A61B17/12118 ,  A61B17/1219 ,  A61B2017/1205 ,  A61F2002/823

摘要： The present invention relates to a medical device for placement at a predetermined location within a vessel of the human body, and more particularly, relates to a collapsible aneurysm embolization device that is delivered through the lumen of a catheter and exits the catheter at a predetermined position within the vessel to thereby embolize a blood vessel defect, such as an aneurysm.

摘要翻译： 本发明涉及一种用于放置在人体容器内的预定位置的医疗装置，更具体地涉及一种可折叠的动脉瘤栓塞装置，其通过导管的内腔输送并在预定位置离开导管 从而栓塞诸如动脉瘤的血管缺损。

公开(公告)号：US5453090A

公开(公告)日：1995-09-26

申请号：US203805

申请日：1994-03-01

申请人： Susana Martinez ,  Margaret F. Yoklavich

发明人： Susana Martinez ,  Margaret F. Yoklavich

IPC分类号： A61F2/06 ,  A61F2/84 ,  A61M31/00

CPC分类号： A61F2/958

摘要： The stent delivery method and apparatus uses an elongate sheath having a rounded or tapered distal end portion which has a central opening and which is constructed in a manner that permits the distal end portion to expand easily. The method comprises the steps of: placing a stent on a balloon catheter or a balloon on a balloon guidewire thereby forming a stent on a balloon assembly; placing the stent on a balloon assembly in the elongate sheath having an elongate axis; pushing the sheath and stent on a balloon assembly to a desired site in the lumen of a vessel; positioning the stent on a balloon assembly at the desired site; withdrawing the sheath from the stent on a balloon assembly causing the distal end portion of the sheath to expand to pass over the stent and leaving the stent and balloon at the desired site in the lumen; expanding the balloon and stent to expand the stent to a desired diameter; collapsing the balloon; and, removing the balloon and the sheath from the lumen. The central opening permits a guidewire tip to extend therethrough.

摘要翻译： 支架输送方法和装置使用具有圆形或锥形的远端部分的细长护套，其具有中心开口并且以允许远端部分容易膨胀的方式构造。 该方法包括以下步骤：将支架放置在球囊导管或球囊导丝上的球囊上，从而在球囊组件上形成支架; 将支架放置在具有细长轴线的细长护套中的气囊组件上; 将护套和支架在球囊组件上推动到血管内腔中的所需位置; 将支架定位在所需位置的球囊组件上; 在球囊组件上将支架从支架上取出，使得护套的远端部分膨胀以越过支架并将支架和球囊留在管腔中的所需位置; 使气囊和支架膨胀以将支架扩张至期望的直径; 塌缩气球 并且从管腔移除气球和护套。 中心开口允许导丝尖端延伸穿过其中。

公开(公告)号：US5593412A

公开(公告)日：1997-01-14

申请号：US432886

申请日：1995-05-02

申请人： Susana Martinez ,  Margaret F. Yoklavich

发明人： Susana Martinez ,  Margaret F. Yoklavich

IPC分类号： A61F2/06 ,  A61F2/84 ,  A61F11/00

CPC分类号： A61F2/958

摘要： The stent delivery method and apparatus uses an elongate sheath having a rounded or tapered distal end portion which has a central opening and which is constructed in a manner that permits the distal end portion to expand easily. The method comprises the steps of: placing a stent on a balloon catheter or a balloon on a balloon guidewire thereby forming a stent on a balloon assembly; placing the stent on a balloon assembly in the elongate sheath having an elongate axis; pushing the sheath and stent on a balloon assembly to a desired site in the lumen of a vessel; positioning the stent on a balloon assembly at the desired site; withdrawing the sheath from the stent on a balloon assembly causing the distal end portion of the sheath to expand to pass over the stent and leaving the stent and balloon at the desired site in the lumen; expanding the balloon and stent to expand the stent to a desired diameter; collapsing the balloon; and, removing the balloon and the sheath from the lumen. The central opening permits a guidewire tip to extend therethrough.

摘要翻译： 支架输送方法和装置使用具有圆形或锥形的远端部分的细长护套，其具有中心开口并且以允许远端部分容易膨胀的方式构造。 该方法包括以下步骤：将支架放置在球囊导管或球囊导丝上的球囊上，从而在球囊组件上形成支架; 将支架放置在具有细长轴线的细长护套中的气囊组件上; 将护套和支架在球囊组件上推动到血管内腔中的所需位置; 将支架定位在所需位置的气囊组件上; 在球囊组件上将支架从支架上取出，使得护套的远端部分膨胀以越过支架并将支架和球囊留在管腔中的所需位置; 使气囊和支架膨胀以将支架扩张至期望的直径; 塌缩气球 并且从管腔移除气球和护套。 中心开口允许导丝尖端延伸穿过其中。