公开(公告)号：US20090258048A1

公开(公告)日：2009-10-15

申请号：US12083927

申请日：2006-12-07

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka ,  Shanger Wang

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka ,  Shanger Wang

IPC分类号： A61F2/02 ,  C08G63/91 ,  C12M3/00 ,  B65D71/00

CPC分类号： A61K31/785 ,  C08G18/0895 ,  C08G18/2875 ,  C08G18/288 ,  C08G18/44 ,  C08G18/6266

摘要： Polymers having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.

摘要翻译： 具有式R（LE）x的聚合物，其中R是数均分子量为5000-7,000,000道尔顿且具有x个端基的聚合物芯，E是通过连接L与聚合物核心R共价连接的端基，L是二价 具有至少5个相同重复单元的低聚链，能够与聚合物的相邻分子上的L链自组装，并且聚合物中的部分（LE）x可以彼此相同或不同。 单体，低聚物或其它类似于已知的自组装单层的单体，低聚物或其它反应性结构的设计，但具有至少一个能够将它们结合到聚合物末端的反应性化学基团，使得无硫醇的SAM类似物变成自组装表面 修饰该聚合物的端基。 使用聚合物从表面改性的聚合物制造配置的制品，或者对由另一种材料制成的制品进行包衣或局部处理。

公开(公告)号：US07884171B2

公开(公告)日：2011-02-08

申请号：US12638371

申请日：2009-12-15

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

IPC分类号： C08G18/00 ,  C08G77/04 ,  C08G77/22

CPC分类号： C08G18/6287 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/289 ,  C08G18/5024 ,  C08G18/5039 ,  C08G18/6283 ,  C08G18/6795 ,  C08L75/04 ,  C08G18/3228

摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.

摘要翻译： 其表面被包括两亲表面改性部分的端基修饰的聚合物。 聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于 当该重新定位导致界面能量降低时，与身体接触的介质。 两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。 例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。 如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶 。 在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。 还公开了利用这些聚合物的方法和制品。

公开(公告)号：US07671162B2

公开(公告)日：2010-03-02

申请号：US11211734

申请日：2005-08-26

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

IPC分类号： C08G18/00 ,  C08G77/04 ,  C08G77/22

CPC分类号： C08G18/6287 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/289 ,  C08G18/5024 ,  C08G18/5039 ,  C08G18/6283 ,  C08G18/6795 ,  C08L75/04 ,  C08G18/3228

摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.

摘要翻译： 其表面被包括两亲表面改性部分的端基修饰的聚合物。 聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于 当该重新定位导致界面能量降低时，与身体接触的介质。 两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。 例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。 如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶 。 在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。 还公开了利用这些聚合物的方法和制品。

公开(公告)号：US20100113711A1

公开(公告)日：2010-05-06

申请号：US12638371

申请日：2009-12-15

申请人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

发明人： Robert S. Ward ,  Keith R. McCrea ,  Yuan Tian ,  James P. Parakka

IPC分类号： C08G69/48 ,  C08G18/00 ,  C08G12/12 ,  C08G63/91 ,  C08G64/42 ,  C08G77/38

CPC分类号： C08G18/6287 ,  A61L27/18 ,  A61L29/06 ,  A61L31/06 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/283 ,  C08G18/2865 ,  C08G18/289 ,  C08G18/5024 ,  C08G18/5039 ,  C08G18/6283 ,  C08G18/6795 ,  C08L75/04 ,  C08G18/3228

摘要： Polymers whose surfaces are modified by endgroups that include amphipathic surface-modifying moieties. An amphipathic endgroup of a polymer molecule is an endgroup that contains at least two moieties of significantly differing composition, such that the amphipathic endgroup spontaneously rearranges its positioning in a polymer body to position the moiety on the surface of the body, depending upon the composition of the medium with which the body is in contact, when that re-positioning causes a reduction in interfacial energy. An example of an amphipathic surface-modifying endgroup is one that has both a hydrophobic moiety and a hydrophilic moiety in a single endgroup. For instance, a hydrophilic poly(ethylene oxide) terminated with a hydrophilic hydroxyl group is not surface active in air when the surface-modifying endgroup is bonded to a more hydrophobic base polymer. If the hydroxyl group on the oligomeric poly(ethylene oxide) is replaced by a hydrophobic methoxy ether terminus, the poly(ethylene oxide) becomes surface active in air, and allows the poly(ethylene oxide) groups to crystallize in the air-facing surface. In this example, immersion in water destroys the crystallinity as the poly(ethylene oxide) sorbs water and the hydrophobic methoxy group retreats below the surface of the polymer. Also disclosed are methods and articles of manufacture that make use of these polymers.

摘要翻译： 其表面被包括两亲表面改性部分的端基修饰的聚合物。 聚合物分子的两亲端基是含有至少两个具有显着不同组成的部分的端基，使得两亲性端基在聚合物体中自发地重排其定位，以将该部分定位在身体的表面上，这取决于 当该重新定位导致界面能量降低时，与身体接触的介质。 两亲性表面改性端基的实例是在单个端基具有疏水部分和亲水部分的实例。 例如，当表面改性端基键合到更疏水的基础聚合物上时，用亲水羟基封端的亲水性聚（环氧乙烷）在空气中不是表面活性的。 如果低聚聚（环氧乙烷）上的羟基被疏水性甲氧基醚末端所代替，则聚（环氧乙烷）在空气中变得表面活性，并允许聚（环氧乙烷）基团在面向空气的表面中结晶 。 在该实施例中，当聚（环氧乙烷）吸附水和疏水性甲氧基在聚合物表面下方退缩时，浸入水中会破坏结晶度。 还公开了利用这些聚合物的方法和制品。

公开(公告)号：US20100179284A1

公开(公告)日：2010-07-15

申请号：US12601787

申请日：2008-05-28

申请人： Robert S. Ward ,  Keith McCrea ,  Yuan Tian ,  Shanger Wang ,  Larry Jones ,  Anfeng Wang ,  James P. Parakka

发明人： Robert S. Ward ,  Keith McCrea ,  Yuan Tian ,  Shanger Wang ,  Larry Jones ,  Anfeng Wang ,  James P. Parakka

IPC分类号： C08B37/10

CPC分类号： A61K31/785 ,  C08G18/3228 ,  C08G18/3271 ,  C08G18/44 ,  C08G18/5024

摘要： Medical device, prosthesis, or packaging assembly made up of polymer body comprising at least one polymer having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons, and having x endgroups, x is an integer≧1, E is an endgroup which is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain which has at least 5 repeat units and which can self-assembly with L chains on adjacent molecules of the polymer, and moieties L and/or E in the polymer(s) may be the same as or different from one another in composition and/or molecular weight. The polymer body includes plural polymer molecules located internally within the body, at least some of which internal polymer molecules have endgroups that form a surface of the body. The surface endgroups include at least one self-assembling moiety.

摘要翻译： 由包含至少一种具有式R（LE）x的聚合物的聚合物主体组成的医疗装置，假体或包装组件，其中R是数均分子量为5000至70000道尔顿的聚合物芯，并且具有x个端基， x是整数≥1，E是通过连接L与聚合物核心R共价连接的端基，L是具有至少5个重复单元的二价低聚链，并且可以与L链相邻的分子自组装 聚合物和聚合物中的部分L和/或E可以在组成和/或分子量上彼此相同或不同。 聚合物主体包括位于体内内部的多个聚合物分子，其中至少一些内部聚合物分子具有形成身体表面的端基。 表面端基包括至少一个自组装部分。