公开(公告)号：US20080035143A1

公开(公告)日：2008-02-14

申请号：US11893040

申请日：2007-08-14

申请人： Robert Sievers ,  Jessica Best ,  Stephen Cape

发明人： Robert Sievers ,  Jessica Best ,  Stephen Cape

IPC分类号： A61M15/00 ,  A61K9/127 ,  A61M13/00

CPC分类号： A61M15/00 ,  A61K9/0075 ,  A61K9/1623 ,  A61K9/1652 ,  A61M11/003 ,  A61M11/008 ,  A61M15/0086 ,  A61M15/0088 ,  A61M16/0078 ,  A61M16/0084 ,  A61M16/0093 ,  A61M16/1055 ,  A61M16/1065 ,  A61M2202/064

摘要： In one embodiment, a human-powered dry powder inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet at a pressure of about 1-40 psi; an inflatable reservoir operable to receive an air pulse discharged from the human-powered compressible component to provide an aerosol of a dry powder pharmaceutical formulation in the reservoir, the reservoir including an outlet valve; and a receiving mask in communication with the outlet valve and operable to receive an aerosol of dry powder from the reservoir and to deliver the aerosol to at least a mouth or nose of a patient. In another embodiment, the inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet of a polymeric pressure release valve at a pressure of about 1-40 psi; and a receiving mask in communication with the outlet of the compressible component and operable to deliver an aerosol of dry powder to at least a mouth or nose of a patient. Methods for delivery of a dry powder pharmaceutical formulation to a patient are conducted in the absence of electrical power and circuitry and pre-pressurized propellant gas. Suitable dry powder pharmaceutical formulations may include myo-inositol and/or maltodextrin as a carrier and active ingredients such as vaccines or siRNA.

摘要翻译： 在一个实施例中，人力干粉吸入器包括人力动力可压缩部件，其可操作以在约1-40psi的压力下排出出口处的空气脉冲; 充气储存器，其可操作以接收从人力可压缩部件排出的空气脉冲，以在储存器中提供干粉末药物制剂的气溶胶，所述储存器包括出口阀; 以及与所述出口阀连通并且可操作以从所述储存器接收干燥粉末的气溶胶并将所述气溶胶输送到患者的至少一个口或鼻部的接收面罩。 在另一个实施例中，吸入器包括人力动力的可压缩部件，其可操作以在约1-40psi的压力下排出聚合物压力释放阀的出口处的空气脉冲; 以及接收面罩，其与所述可压缩部件的出口连通并且可操作以将干粉的气溶胶输送到患者的至少一个口或鼻部。 在没有电力和电路和预加压推进剂气体的情况下，将干粉药物制剂递送到患者的方法进行。 合适的干粉药物制剂可以包括肌醇和/或麦芽糖糊精作为载体和活性成分例如疫苗或siRNA。