公开(公告)号：US20080035143A1

公开(公告)日：2008-02-14

申请号：US11893040

申请日：2007-08-14

申请人： Robert Sievers ,  Jessica Best ,  Stephen Cape

发明人： Robert Sievers ,  Jessica Best ,  Stephen Cape

IPC分类号： A61M15/00 ,  A61K9/127 ,  A61M13/00

CPC分类号： A61M15/00 ,  A61K9/0075 ,  A61K9/1623 ,  A61K9/1652 ,  A61M11/003 ,  A61M11/008 ,  A61M15/0086 ,  A61M15/0088 ,  A61M16/0078 ,  A61M16/0084 ,  A61M16/0093 ,  A61M16/1055 ,  A61M16/1065 ,  A61M2202/064

摘要： In one embodiment, a human-powered dry powder inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet at a pressure of about 1-40 psi; an inflatable reservoir operable to receive an air pulse discharged from the human-powered compressible component to provide an aerosol of a dry powder pharmaceutical formulation in the reservoir, the reservoir including an outlet valve; and a receiving mask in communication with the outlet valve and operable to receive an aerosol of dry powder from the reservoir and to deliver the aerosol to at least a mouth or nose of a patient. In another embodiment, the inhaler comprises a human-powered compressible component operable to discharge an air pulse at an outlet of a polymeric pressure release valve at a pressure of about 1-40 psi; and a receiving mask in communication with the outlet of the compressible component and operable to deliver an aerosol of dry powder to at least a mouth or nose of a patient. Methods for delivery of a dry powder pharmaceutical formulation to a patient are conducted in the absence of electrical power and circuitry and pre-pressurized propellant gas. Suitable dry powder pharmaceutical formulations may include myo-inositol and/or maltodextrin as a carrier and active ingredients such as vaccines or siRNA.

摘要翻译： 在一个实施例中，人力干粉吸入器包括人力动力可压缩部件，其可操作以在约1-40psi的压力下排出出口处的空气脉冲; 充气储存器，其可操作以接收从人力可压缩部件排出的空气脉冲，以在储存器中提供干粉末药物制剂的气溶胶，所述储存器包括出口阀; 以及与所述出口阀连通并且可操作以从所述储存器接收干燥粉末的气溶胶并将所述气溶胶输送到患者的至少一个口或鼻部的接收面罩。 在另一个实施例中，吸入器包括人力动力的可压缩部件，其可操作以在约1-40psi的压力下排出聚合物压力释放阀的出口处的空气脉冲; 以及接收面罩，其与所述可压缩部件的出口连通并且可操作以将干粉的气溶胶输送到患者的至少一个口或鼻部。 在没有电力和电路和预加压推进剂气体的情况下，将干粉药物制剂递送到患者的方法进行。 合适的干粉药物制剂可以包括肌醇和/或麦芽糖糊精作为载体和活性成分例如疫苗或siRNA。

公开(公告)号：US20070026279A1

公开(公告)日：2007-02-01

申请号：US11542414

申请日：2006-10-03

申请人： Robert Hirsch ,  Paul Mutolo ,  Juan Becerra ,  Robert Sievers ,  J. Scartozzi ,  William Acker

发明人： Robert Hirsch ,  Paul Mutolo ,  Juan Becerra ,  Robert Sievers ,  J. Scartozzi ,  William Acker

IPC分类号： H01M8/04

CPC分类号： H01M8/0637 ,  H01M8/04089 ,  H01M8/04186 ,  H01M8/04201 ,  H01M8/04208 ,  H01M8/1011 ,  H01M2008/1095 ,  Y02E60/523 ,  Y02E60/566

摘要： An adjustable fuel delivery regulation assembly is provided which can be disposed within a direct oxidation fuel cell system, or the fuel reservoir or fuel tank that supplies such a system. One embodiment of the fuel delivery regulation assembly is a shutter assembly, which includes two correspondingly perforated components. The two components can be positioned relative to one another such that the apertures in each component are aligned in certain ways. In an open position, the apertures are substantially fully aligned to permit full fuel flow. In a closed position, the apertures are offset such that there is no opening; thereby fuel flow is restricted. Intermediate positions allow adjustments in the amount of fuel flow proportional to the size of the openings. In accordance with another embodiment of the invention, a set of rotatably mounted slotted rods is inserted into a housing through which fuel can flow through openings in the housing. When the rods are rotated to a first position, the slots in the rods are aligned with the openings in the housing. When the rods are rotated to a closed position, the slots are not lined up with the openings, and fuel flow is thereby restricted. Intermediate positions allow controlled fuel delivery. A louvered assembly is also provided. Automatic and manual control systems for the adjustment of the positioning of the various components in the fuel delivery regulation assemblies are also provided.

摘要翻译： 提供了可调节的燃料输送调节组件，其可以设置在直接氧化燃料电池系统内，或者提供这种系统的燃料储存器或燃料箱。 燃料输送调节组件的一个实施例是快门组件，其包括两个相应的穿孔部件。 两个部件可以相对于彼此定位，使得每个部件中的孔以某些方式对准。 在打开位置，孔基本上完全对齐，以允许完全燃料流动。 在关闭位置，孔被偏移使得不存在开口; 从而燃料流量受到限制。 中间位置允许调节与开口尺寸成比例的燃料流量。 根据本发明的另一个实施例，一组可旋转地安装的开槽杆被插入壳体中，燃料可以通过该壳体流过壳体中的开口。 当杆旋转到第一位置时，杆中的狭槽与壳体中的开口对准。 当杆旋转到关闭位置时，槽不与开口对齐，因此燃料流被限制。 中间位置允许控制燃料输送。 还提供百叶窗组件。 还提供了用于调节燃料输送调节组件中的各种部件的定位的自动和手动控制系统。