公开(公告)号：US20070128672A1

公开(公告)日：2007-06-07

申请号：US11421368

申请日：2006-05-31

申请人： Robyn Ward ,  David Coomber

发明人： Robyn Ward ,  David Coomber

IPC分类号： G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： G01N33/57484 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/55 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to nucleotide sequences which encode polypeptides of antibodies against the p53 protein in vertebrates, and to the polypeptides and antibodies (or fragments thereof) encoded by those nucleotide sequences. The invention also relates to nucleotide sequences and polypeptide sequences for use in the development of diagnostic and therapeutic compositions, and to methods of using those diagnostic and therpeutic compositions in the diagnosis and treatment of cancer, rheumatoid arthritis and other disease states which exhibit abnormalities of p53.

摘要翻译： 本发明涉及编码脊椎动物中针对p53蛋白的抗体多肽的核苷酸序列，以及由这些核苷酸序列编码的多肽和抗体（或其片段）。 本发明还涉及用于开发诊断和治疗组合物的核苷酸序列和多肽序列，以及将这些诊断和治疗组合物用于诊断和治疗癌症，类风湿性关节炎和其它呈现p53异常的疾病状态的方法 。

公开(公告)号：US20060159693A1

公开(公告)日：2006-07-20

申请号：US10546901

申请日：2004-02-23

申请人： Robyn Ward

发明人： Robyn Ward

IPC分类号： A61K39/00

CPC分类号： C07K16/30 ,  A61K39/0011 ,  C07K2317/565

摘要： The present invention relates to idiotypic vaccine compositions for use in inducing immunity to p53. The invention preferably relates to a vaccine composition comprising a pharmaceutically acceptable carrier and at least one peptide, wherein the at least one peptide is selected from the group consisting of X1-LLQALKH-Y1, X2-FIRKAYGAATAYAASKKG-Y2 and X3-MQGLQTPYT-Y3 in which X1, X2, X3, Y1, Y2 and Y3 are independently either absent or an amino acid sequence of preferably less than 10 amino acids which provides a framework for the specified peptide.

摘要翻译： 本发明涉及用于诱导对p53的免疫的独特型疫苗组合物。 本发明优选涉及包含药学上可接受的载体和至少一种肽的疫苗组合物，其中所述至少一种肽选自X 1 -LLQALKH-Y 1， / SUB>，X 2 -FIRKAYGAATAYAASKKG-Y 2和X 3 -MQGLQTPYT-Y 3其中X X 1，X 2，X 3，Y 1，Y 2和Y 3个或3个独立地不存在或优选小于10个氨基酸的氨基酸序列，其提供了特定肽的框架。