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    Membrane-Translocating Peptides
    5.
    发明申请
    Membrane-Translocating Peptides 有权
    膜 - 位移肽

    公开(公告)号：US20080287311A1

    公开(公告)日：2008-11-20

    申请号：US11996496

    申请日：2006-07-24

    申请人： David Coomber ,  Kevin Fitzgerald ,  Duncan McGregor ,  Chris Ullman ,  Tomas Leanderson

    发明人： David Coomber ,  Kevin Fitzgerald ,  Duncan McGregor ,  Chris Ullman ,  Tomas Leanderson

    IPC分类号： C40B30/04 ,  C07K14/00 ,  C07H21/00 ,  C12N5/06

    CPC分类号： C12N15/1075

    摘要： A method is provided for selecting membrane-translocating peptides (MTPs) from a peptide display library that are capable of crossing or penetrating a lipid membrane. A plurality of nucleic acid constructs that encode displayed peptides are expressed, resulting in the formation of a plurality of nucleic acid-peptide complexes, each complex comprising at least one displayed peptide associated with the corresponding nucleic acid construct encoding the displayed peptide; the complexes are exposed to a population of membrane-encapsulated compartments, allowing a translocating reaction to occur; complexes that remain unassociated with the membrane are removed; optionally complexes that are associated with the membrane are removed; and internalised nucleic acid-peptide complexes are recovered. The membrane-encapsulated compartments may be artificial vesicles such as liposomes, or populations of one or more cell types.

    摘要翻译： 提供了从能够穿透或穿透脂质膜的肽展示文库中选择膜转位肽（MTP）的方法。 表达编码显示的肽的多个核酸构建体，导致形成多个核酸 - 肽复合物，每个复合物包含与编码所显示肽的相应核酸构建体相关联的至少一个显示的肽; 复合物暴露于膜包封的隔室群，允许发生易位反应; 与膜保持不相关的复合物被去除; 去除与膜相关的任选复合物; 并回收内化的核酸 - 肽复合物。 膜包封的隔室可以是人造囊泡，例如脂质体或一种或多种细胞类型的群体。

    DRIVE SYSTEM FOR AN OPTICALLY ADDRESSED SPATIAL LIGHT MODULATOR
    6.
    发明申请
    DRIVE SYSTEM FOR AN OPTICALLY ADDRESSED SPATIAL LIGHT MODULATOR 审中-公开
    用于光学遥控调光器的驱动系统

    公开(公告)号：US20080211836A1

    公开(公告)日：2008-09-04

    申请号：US12028697

    申请日：2008-02-08

    申请人： Maurice STANLEY ,  Stuart David Coomber

    发明人： Maurice STANLEY ,  Stuart David Coomber

    IPC分类号： G09G5/02

    CPC分类号： G09G3/02 ,  G03H1/2294 ,  G03H2225/25 ,  G09G3/36 ,  G09G2310/061 ,  G09G2320/0204 ,  G09G2360/141

    摘要： A system includes a driving apparatus configured to operate on an optically addressed spatial light modulator (OASLM) including a modulation layer notionally divided into a plurality of separately addressable segments. A pulse generator is configured to provide one or more voltage patterns and an optical pattern generator configured to provide one or more optical patterns of light. For each segment of the OASLM, the driving apparatus is further configured to write, over a predetermined number of write operations, a predetermined amount of light associated with the one or more optical patterns. The driving apparatus is configured to apply a reset pulse associated with the one or more voltage patterns, such that a resulting net charge on the modulation layer is zero.

    摘要翻译： 一种系统包括配置为在光学寻址的空间光调制器（OASLM）上操作的驱动装置，所述光学寻址的空间光调制器（OASLM）包括被划分成多个单独可寻址的片段的调制层。 脉冲发生器被配置为提供一个或多个电压图案和被配置为提供一个或多个光学图案的光学图案发生器。 对于OASLM的每个部分，驱动装置还被配置为在预定数量的写入操作中写入与一个或多个光学图案相关联的预定量的光。 驱动装置被配置为施加与一个或多个电压图案相关联的复位脉冲，使得调制层上产生的净电荷为零。

    OASLM and a method and apparatus for driving an OASLM
    8.
    发明授权
    OASLM and a method and apparatus for driving an OASLM 有权
    OASLM和用于驱动OASLM的方法和装置

    公开(公告)号：US07265893B2

    公开(公告)日：2007-09-04

    申请号：US10531080

    申请日：2003-10-06

    申请人： Jonathan Rennie Hughes ,  Stuart David Coomber ,  Carl Vernon Brown ,  Alexander John Topping

    发明人： Jonathan Rennie Hughes ,  Stuart David Coomber ,  Carl Vernon Brown ,  Alexander John Topping

    IPC分类号： G02B26/00

    CPC分类号： G02F1/135 ,  G02F1/141

    摘要： A method of controlling the switching of an optically addressable spatial light modulator (OASLM), to a first surface of which a write light signal is applied and to a second surface of which a read light signal is applied. The method comprises applying a bipolar switching waveform to control electrodes of the (OASLM) during each write cycle such that the leading pulse of the waveform applies a voltage across the (OASLM) which is in the photosensitive direction and the trailing pulse applies a voltage which is not in the photosensitive direction.

    摘要翻译： 一种控制光可寻址空间光调制器（OASLM）切换到施加写入光信号的第一表面和施加读取光信号的第二表面的方法。 该方法包括在每个写入周期期间将双极性切换波形施加到（OASLM）的控制电极，使得波形的引导脉冲施加在感光方向上的（OASLM）两端的电压，并且拖尾脉冲施加电压， 不在感光方向。

    Anti-p53 Antibodies
    9.
    发明申请
    Anti-p53 Antibodies 审中-公开
    抗p53抗体

    公开(公告)号：US20070128672A1

    公开(公告)日：2007-06-07

    申请号：US11421368

    申请日：2006-05-31

    申请人： Robyn Ward ,  David Coomber

    发明人： Robyn Ward ,  David Coomber

    IPC分类号： G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC分类号： G01N33/57484 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/55 ,  C12Q1/6883 ,  C12Q2600/156

    摘要： The present invention relates to nucleotide sequences which encode polypeptides of antibodies against the p53 protein in vertebrates, and to the polypeptides and antibodies (or fragments thereof) encoded by those nucleotide sequences. The invention also relates to nucleotide sequences and polypeptide sequences for use in the development of diagnostic and therapeutic compositions, and to methods of using those diagnostic and therpeutic compositions in the diagnosis and treatment of cancer, rheumatoid arthritis and other disease states which exhibit abnormalities of p53.

    摘要翻译： 本发明涉及编码脊椎动物中针对p53蛋白的抗体多肽的核苷酸序列，以及由这些核苷酸序列编码的多肽和抗体（或其片段）。 本发明还涉及用于开发诊断和治疗组合物的核苷酸序列和多肽序列，以及将这些诊断和治疗组合物用于诊断和治疗癌症，类风湿性关节炎和其它呈现p53异常的疾病状态的方法 。

    Method for auto-configuration of a wavelength selective switch in an optical network
    10.
    发明授权
    Method for auto-configuration of a wavelength selective switch in an optical network 有权
    光网络中波长选择开关的自动配置方法

    公开(公告)号：US08948592B2

    公开(公告)日：2015-02-03

    申请号：US12714600

    申请日：2010-03-01

    申请人： Thomas Haslam ,  David Coomber ,  Daniel Doliska ,  Michael Scott Pegrum ,  Marc-Antoine Boutin ,  Brian Sungwan Kim

    发明人： Thomas Haslam ,  David Coomber ,  Daniel Doliska ,  Michael Scott Pegrum ,  Marc-Antoine Boutin ,  Brian Sungwan Kim

    IPC分类号： H04J14/02

    CPC分类号： H04Q11/0005 ,  H04J14/0201 ,  H04J14/0204 ,  H04J14/0206 ,  H04J14/0212 ,  H04Q2011/0037

    摘要： The invention relates to a method for auto-configuring a wavelength selective switch (WSS) device having an output port and a plurality of input ports and coupled to a WSS controller. When connected to a WDM optical network, the WSS controller is programmed to utilize one or more optical channel monitors (OCM) coupled to the input and/or output ports to detect which of the wavelengths are present at the input ports. Wavelengths that are not detected on any input port are blocked by the WSS. Any wavelength detected as present at one and only one input port is switched by the WSS to the output port. If a wavelength is detected at two or more input ports, it is either blocked by the WSS at each of the input ports until user intervention, or is blocked at all but one of the input ports as defined by assigned port priorities.

    摘要翻译： 本发明涉及一种用于自动配置具有输出端口和多个输入端口并耦合到WSS控制器的波长选择开关（WSS）设备的方法。 当连接到WDM光网络时，WSS控制器被编程为利用耦合到输入和/或输出端口的一个或多个光通道监视器（OCM）来检测在输入端口处存在哪些波长。 在任何输入端口上未检测到的波长被WSS阻止。 在一个且仅一个输入端口上检测到的任何波长被WSS切换到输出端口。 如果在两个或更多个输入端口检测到波长，则在每个输入端口由WSS阻塞，直到用户干预，或者由分配的端口优先级定义的除输入端口之外的所有输入端口都被阻塞。