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公开(公告)号:US09126999B2
公开(公告)日:2015-09-08
申请号:US13907202
申请日:2013-05-31
申请人: Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
发明人: Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00 , C07D471/04 , C07D487/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
摘要翻译: 本公开的实施方案涉及用作Toll样受体7和/或8的拮抗剂或抑制剂的四氢吡唑并嘧啶化合物及其在有效治疗系统性红斑狼疮(SLE)和狼疮性肾炎的药物组合物中的用途。
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公开(公告)号:US20130324547A1
公开(公告)日:2013-12-05
申请号:US13907202
申请日:2013-05-31
申请人: Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
发明人: Roch Boivin , Eric Carlson , Atsushi Endo , Hans Hansen , Lynn D. Hawkins , Sally Ishizaka , Matthew Mackey , Sridhar Narayan , Takashi Satoh , Shawn Schiller
IPC分类号: C07D471/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/55 , C07D487/04 , Y02P20/582
摘要: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis
摘要翻译: 本公开的实施方案涉及用作Toll样受体7和/或8的拮抗剂或抑制剂的四氢吡唑并嘧啶化合物及其在有效治疗系统性红斑狼疮(SLE)和狼疮性肾炎的药物组合物中的用途
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