公开(公告)号：US09631233B2

公开(公告)日：2017-04-25

申请号：US14855915

申请日：2015-09-16

Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.

Inventor： Thomas Metzler ,  Tobias Haslinger ,  Annette Peceny ,  Harald Sobek

IPC: C12P19/34 ,  C12Q1/68 ,  C12N9/12

CPC classification number: C12Q1/686 ,  C12N9/1252 ,  C12Q1/6876

Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.

公开(公告)号：US09163286B2

公开(公告)日：2015-10-20

申请号：US14169993

申请日：2014-01-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Metzler ,  Tobias Haslinger ,  Annette Peceny ,  Harald Sobek

IPC: C12P19/34 ,  C12Q1/68 ,  C12N9/12

CPC classification number: C12Q1/686 ,  C12N9/1252 ,  C12Q1/6876

Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.

Abstract translation: 本发明提供了获得干燥组合物的方法，所述反应化合物在一定的储存时间后再溶解时维持化合物的生物活性。 优选地，干组合物包含聚合酶，并且干组合物可用于再溶解后的聚合酶链反应（PCR）扩增。