公开(公告)号：US11372000B2

公开(公告)日：2022-06-28

申请号：US16538886

申请日：2019-08-13

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus Hallermayer ,  Monika Soukupova ,  Christina Porzig ,  Ulrike Kurtkaya ,  Leopold Von Proff ,  Sonja Fiesel ,  Marion Herrmann ,  Stefanie Kern

IPC: C07K16/26 ,  A61K39/395 ,  G01N33/68 ,  C07K14/575 ,  C07K14/58

Abstract: The present disclosure relates to an antibody that specifically binds a mutated NT-proBNP having i) a mutation substituting arginine at position 46 with histidine or ii) a mutation substituting glutamic acid at position 43 with aspartic acid. Moreover, the present disclosure relates to a mutated NT-proBNP or fragment thereof. Further, envisaged by the present disclosure are kits containing the antibody of the present disclosure, or the mutated NT-proBNP of the present disclosure. The present disclosure also concerns a method for diagnosing heart failure.